Entry |
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Name |
N-methyl-2-oxoglutaramate hydrolase;
5-hydroxy-N-methylpyroglutamate synthase
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Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
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Sysname |
N-methyl-2-oxoglutaramate methylamidohydrolase
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Reaction(IUBMB) |
N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylamine [RN: R01587]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
In the reverse reaction, the product cyclizes non-enzymically to 2-hydroxy-N-methyl-5-oxo-L-proline.
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History |
EC 3.5.1.36 created 1972
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Reference |
|
Authors |
Hersh LB. |
Title |
5-hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action. |
Journal |
J Biol Chem 245:3526-35 (1970) |
Reference |
|
Authors |
Hersh LB, Tsai L, Stadtman ER. |
Title |
The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid. |
Journal |
J Biol Chem 244:4677-83 (1969) |
Other DBs |
ExplorEnz - The Enzyme Database: | 3.5.1.36 |
ExPASy - ENZYME nomenclature database: | 3.5.1.36 |
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LinkDB |
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