Entry
Name
pantetheine hydrolase;
pantetheinase;
vanin;
vanin-1
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
(R)-pantetheine amidohydrolase
Reaction(IUBMB)
(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol [RN:
R02973 ]
Reaction(KEGG)
Substrate
Product
(R)-pantothenate [CPD:
C00864 ];
2-aminoethanethiol [CPD:
C01678 ]
Comment
The enzyme hydrolyses only one of the amide bonds of pantetheine. The substrate analogues phosphopantetheine and CoA are not substrates. The enzyme recycles pantothenate (vitamin B5) and produces 2-aminoethanethiol (cysteamine), a potent anti-oxidant [5].
History
EC 3.5.1.92 created 2006
Pathway
ec00770 Pantothenate and CoA biosynthesis
Orthology
Genes
HSA : 8875(VNN2) 8876(VNN1)
PTR : 463006(VNN3) 463007(VNN2) 746544(VNN1)
PPS : 100978332 100978987(VNN3) 100979321(VNN2)
GGO : 101125335 101126064(VNN3) 101126426(VNN2)
PON : 100436777 100441056(VNN1) 100441798(VNN3)
NLE : 100579766(VNN1) 100580443(VNN3) 115830450
HMH : 116472399 116472421(VNN3) 116472484
MCC : 708637 708748 708830
MCF : 101865481(VNN2) 102139623 102139985
MTHB : 126952876 126952877 126952878
MNI : 105465628 105465629 105465630(VNN2)
CSAB : 103240351(VNN2) 103240352 103240354
CATY : 105600441(VNN2) 105600443 105600573
PANU : 101022791(VNN2) 101023852 101024198(VNN1)
TGE : 112622739(VNN2) 112622834 112622835
MLEU : 105531096(VNN2) 105531097 105535035(VNN1) 105535149
RRO : 104657993(VNN2) 104657995 104657997
RBB : 108534302(VNN1) 108534304 108534340
TFN : 117097514(VNN2) 117097515 117097516(VNN1)
PTEH : 111554892(VNN1) 111554930(VNN2) 111554957(VNN3)
CANG : 105526209(VNN2) 105526211(VNN3) 105526250
CJC : 100399050(VNN1) 100399411(VNN3P) 100895783
SBQ : 101042912 101043241(VNN1)
CIMI : 108283984(VNN1) 108283985(VNN3)
CSYR : 103260966(VNN1) 103260967(VNN3) 103260969
MMUR : 105855558 105855559(VNN1) 105855561
LCAT : 123633282(VNN1) 123633283 123633284
PCOQ : 105827199(VNN1) 105827200 105827203
OGA : 100951307 100959690 100959693 100960002
MMU : 22361(Vnn1) 26464(Vnn3)
MCAL : 110303054(Vnn1) 110303935
MPAH : 110338225(Vnn1) 110338323
RNO : 29142(Vnn1) 498992(Vnn3)
MCOC : 116097698 116097699
ANU : 117701008(Vnn1) 117701029
CGE : 100750608(Vnn1) 100754161
MAUA : 101825185 110339751(Vnn1)
AAMP : 119820817 119821684
NGI : 103724951(Vnn2) 103724954(Vnn1)
HGL : 101710059(Vnn1) 101724572(Vnn3)
CPOC : 100728678(Vnn1) 100728953(Vnn3)
CCAN : 109687502(Vnn1) 109687517(Vnn2)
DORD : 105993512(Vnn1) 105993513
PLOP : 125357296(Vnn1) 125357732
NCAR : 124988630 124989575 124989745
MMMA : 107155491(Vnn1) 107155505(Vnn2)
OCU : 100344919 100345689 100356303
TUP : 102490124(VNN1) 102490829(VNN3) 102491237(VNN2)
GVR : 103602493(VNN1) 103602503 103602521
UAH : 113259459(VNN1) 113259677(VNN3)
ORO : 101376044(VNN1) 101385601(VNN3)
EJU : 114225647(VNN3) 114225655
NSU : 110583229(VNN1) 110583238
PYU : 121013451(VNN1) 121013452
PCOO : 112862121 112862287
PVIV : 125165148 125165656(VNN1)
LRUF : 124528590 124529365
PTG : 102970509(VNN3) 102971182(VNN1)
PPAD : 109249916(VNN1) 109249917
BTA : 526704(VNN1) 534929(VNN2)
BOM : 102269407(VNN1) 102269960(VNN2)
BIU : 109563954(VNN1) 109563957
BBUB : 102410831(VNN2) 102411389(VNN1)
BBIS : 104991694(VNN2) 104991697(VNN1)
CHX : 102172899(VNN1) 102173569
OAS : 101105005(VNN1) 101105417(VNN2)
BTAX : 128053288 128053334(VNN2)
ODA : 120863042(VNN1) 120863045(VNN2)
CCAD : 122434053 122434054(VNN1)
MBEZ : 129560941 129561107
SSC : 100152784(VNN3) 100153984(VNN2) 397246(VNN1)
CFR : 102514326 102514743(VNN3) 102515010(VNN2)
CBAI : 105077234(VNN1) 105077235 105077236(VNN2)
CDK : 105096352(VNN1) 105096353(VNN3) 105096354(VNN2)
VPC : 102539632 102540045(VNN3) 102540292(VNN2)
BACU : 103010543(VNN1) 103011016 103011299(VNN2)
BMUS : 118904951 118904953 118904957
LVE : 103079030(VNN2) 103079497(VNN1) 103084601
OOR : 101284042(VNN2) 101284462(VNN1)
DLE : 111165830(VNN2) 111165838(VNN1)
PCAD : 102989061 102995508(VNN2)
PSIU : 116763260(VNN2) 116763733(VNN1)
NASI : 112409092 112409114(VNN1) 112409135(VNN2)
ECB : 100067649 100067672(VNN2) 100146975
EPZ : 103557081(VNN2) 103557083 103557085(VNN1)
EAI : 106840575 106840577 106840579
MYB : 102246494(VNN1) 102247599 102247887(VNN2)
MYD : 102761007(VNN1) 102761476(VNN2) 102772945
MMYO : 118659851 118660324 118660430
MLF : 102424773 102425091 102440862(VNN2)
PKL : 118706142(VNN1) 118706143 118706144
EFUS : 103285078 103305552(VNN2) 103305561
MNA : 107530954 107530955 107530957(VNN1)
SHON : 118986690(VNN2) 118986693 118986770
PDIC : 114494440(VNN2) 114494515
PHAS : 123821368(VNN2) 123821617
MMF : 118621074(VNN2) 118621116 118621118
PPAM : 129066927 129066928 129067782
HAI : 109372141(VNN1) 109372142 109372153 109395289
RFQ : 117019053 117020605 117020619
PALE : 102881910 102882154 102894153(VNN2)
PGIG : 120615808(VNN2) 120615809 120615810(VNN1)
PVP : 105289491(VNN2) 105289492 105289493
RAY : 107499937(VNN3) 107499949(VNN1) 107499950(VNN2)
MJV : 108397063(VNN2) 108398567 108398575
SARA : 101550949(VNN2) 101551220 101553342
LAV : 100670289 100671136(VNN1)
TMU : 101350854 101351285 101351544 101352933
ETF : 101650218(VNN2) 101650530(VNN1) 101657922
DNM : 101431017(VNN2) 101432321 101433074(VNN1)
MDO : 100031271(VNN1) 100031277(VNN3)
OAA : 100074927(VNN1) 100085853
PCOC : 116240276 116240286
CJO : 107311722(VNN1) 107311723
TPAI : 128089126 128089135
APLA : 101798228 101798418 101798651
ACYG : 106032501 106032502 106032503(VNN1)
CATA : 118243867 118244010 118244011
AFUL : 116487964 116488055
SCAN : 103820544 103820609
PMOA : 120501231 120501233
GFR : 102038583(VNN1) 102041126(VNN2)
FAB : 101807492(VNN1) 101808136
PMAJ : 107201269 107202003
CCAE : 111927686 111927687
CCW : 104690571 104690581 120411723
CBRC : 103619321 103619323 103619430
MMEA : 130572596 130572598 130572599
FPG : 101924145(VNN3) 101924317
EGZ : 104131148 104131149 104131209
NNI : 104008832 104008833 104008895
PCRI : 104036061 104036070
PLET : 104617008 104618055 104618474
EHS : 104503488 104505046 104510687
PCAO : 104040252 104041959
ACUN : 113478767 113478768
TALA : 104357197 104357198 104357199
PADL : 103912691 103912692 103912737
AFOR : 103900749 103900751 103900811
HALD : 104311949 104322071 104322212
HLE : 104836426 104836427 104841707
AGEN : 126038976 126038986
CCRI : 104164598 104164599 104164600
CSTI : 104550535 104551148 104551731
CMAC : 104479085 104484334 104484335
BREG : 104640481 104640482 104641728
GSTE : 104263031 104263032 104263034
LDI : 104343154 104344396 104344399
OHA : 104327060 104327062 104327100
NNT : 104407474 104407475 104407476
SHAB : 115609597 115609598 115609599
DPUB : 104308652 104308653
PGUU : 104466262(VNN1) 104466265 104466266
ACAR : 104519000 104521607
AVIT : 104272794 104272795
CVF : 104282097 104282098 104282124
RTD : 128907274 128907275 128907512
CUCA : 104058236 104058237
TEO : 104382842 104383006 104383016
BRHI : 104490011 104498401
AROW : 112969461 112969462 112969471
NPD : 112954906 112954924 112954925
SCAM : 104153126 104153127 104153166
ASN : 102384310 102384548 102386374
AMJ : 102558568 102560408 102560855(VNN2)
CPOO : 109312025 109312026 109312027
GGN : 109299757 109299761 109299762
PSS : 102445936(VNN1) 102446172
CPIC : 101933999 122172113
CABI : 116824890 116824891(VNN1)
ASAO : 132760978(VNN1) 132760979
PVT : 110071965 110071970(VNN1)
SUND : 121928449 121928453
PMUR : 107297840 107297842 107297843 107299200
CTIG : 120299250 120299293
TSR : 106541945 106543075 106551933(VNN3)
PGUT : 117666274 117666276
APRI : 131192449 131192455
PTEX : 113439597(VNN1) 113439601
PMUA : 114594152 114594153
PRAF : 128410546 128410547
GJA : 107110525(VNN1) 107110527
STOW : 125429402(VNN1) 125438954
XTR : 496642(vnn1) 496713(vnn2)
RTEM : 120937325 120937326
BBUF : 120998503(VNN1) 120998504
BGAR : 122934963 122936134
MUO : 115465813 115466895(VNN1)
BBEL : 109461734 109480583 109486691
PCHN : 125024539 125048283
PPOI : 119097192 119097862 119114813
DPTE : 113791482 113793022 113793031
DFR : 124495498 124495976 124499332
CSCU : 111631959 111631967 111632207
PTEP : 107443103 107445458 107445778
ABRU : 129961103 129963782 129964020 129964039 129964205 129972662
UDV : 129217225 129223377 129224593 129224916 129231644
LGI : LOTGIDRAFT_128172 LOTGIDRAFT_204287 LOTGIDRAFT_218395
PVUL : 126824406 126828239 126828240
PCAN : 112557879 112570933
GAE : 121383811 121390084 121390479
HRF : 124116384 124116395 124116396 124117751 124152859
HRJ : 124257501 124262810 124279646
MYI : 110445423 110452379 110463544
PMAX : 117317063 117320438 117333384 117333873 117344473
MCAF : 127712520 127712521 127720838 127729463
RPHI : 132730077 132730087 132732357 132753748 132757146 132757147 132757152 132758016 132758020 132758021
DPOL : 127833490 127860185 127860381 127869323 127876282
OBI : 106868079 106868152 106874210
OSN : 115209793 115213146 115226225
LAK : 106153227 106179638 106179639
ATEN : 116300340 116300841
DGT : 114524553 114524573 114527090
» show all
Taxonomy
Reference
Authors
Dupre S, Cavallini D.
Title
Purification and properties of pantetheinase from horse kidney.
Journal
Reference
Authors
Dupre S, Chiaraluce R, Nardini M, Cannella C, Ricci G, Cavallini D.
Title
Continuous spectrophotometric assay of pantetheinase activity.
Journal
Reference
Authors
Maras B, Barra D, Dupre S, Pitari G.
Title
Is pantetheinase the actual identity of mouse and human vanin-1 proteins?
Journal
Sequence
Reference
Authors
Aurrand-Lions M, Galland F, Bazin H, Zakharyev VM, Imhof BA, Naquet P.
Title
Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing.
Journal
Sequence
Reference
Authors
Pitari G, Malergue F, Martin F, Philippe JM, Massucci MT, Chabret C, Maras B, Dupre S, Naquet P, Galland F.
Title
Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice.
Journal
Sequence
Reference
Authors
Martin F, Malergue F, Pitari G, Philippe JM, Philips S, Chabret C, Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F.
Title
Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes.
Journal
Sequence
Reference
Authors
Pace HC, Brenner C.
Title
The nitrilase superfamily: classification, structure and function.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.92
ExPASy - ENZYME nomenclature database: 3.5.1.92
LinkDB
All DBs