KEGG ENZYME: 3.5.1.95

ENZYME: 3.5.1.95

Entry

EC 3.5.1.95                 Enzyme

Name

N-malonylurea hydrolase;
ureidomalonase

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides

Sysname

3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming)

Reaction(IUBMB)

3-oxo-3-ureidopropanoate + H2O = malonate + urea [RN:R07629]

Reaction(KEGG)

R07629;
(other) R10778

Substrate

3-oxo-3-ureidopropanoate [CPD:C15607];
H2O [CPD:C00001]

Product

malonate [CPD:C00383];
urea [CPD:C00086]

Comment

Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 1.17.99.4 (uracil/thymine dehydrogenase) and EC 3.5.2.1 (barbiturase).

History

EC 3.5.1.95 created 2006

Pathway

ec00240

Pyrimidine metabolism

ec01100

Metabolic pathways

Orthology

K19795

ureidomalonase

Genes

EGI:	PZN02_005863 PZN02_005872

RHA:	RHA1_ro05297

RER:

RER_58810

REY:

O5Y_28305

REB:	XU06_28635

RQI:	C1M55_30120

ROP:

ROP_27980

ROA:	Pd630_LPD01827

RFA:	A3L23_03490(aam_3)

RHS:	A3Q41_04765(aam_3)

RHOD:

AOT96_09770

RKO:	JWS14_16510

RPSK:

JWS13_28130

SBAT:

G4Z16_27235

SEN:

SACE_1914

SACG:

FDZ84_21730

AAB:	A4R43_34225

AMYY:

YIM_43870(aam4)

» show all

Reference

1 [PMID:11485332]

Authors

Soong CL, Ogawa J, Shimizu S.

Title

Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase.

Journal

Biochem Biophys Res Commun 286:222-6 (2001)
DOI:10.1006/bbrc.2001.5356

Reference

2 [PMID:11748240]

Authors

Soong CL, Ogawa J, Sakuradani E, Shimizu S

Title

Barbiturase, a novel zinc-containing amidohydrolase involved in oxidative pyrimidine metabolism.

Journal

J Biol Chem 277:7051-8 (2002)
DOI:10.1074/jbc.M110784200

Other DBs

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