KEGG   ENZYME: 3.5.4.30
Entry
EC 3.5.4.30                 Enzyme                                 
Name
dCTP deaminase (dUMP-forming)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
dCTP aminohydrolase (dUMP-forming)
Reaction(IUBMB)
dCTP + 2 H2O = dUMP + diphosphate + NH3 [RN:R07307]
Reaction(KEGG)
R07307
Substrate
dCTP [CPD:C00458];
H2O [CPD:C00001]
Product
dUMP [CPD:C00365];
diphosphate [CPD:C00013];
NH3 [CPD:C00014]
Comment
Requires Mg2+. Is highly specific for dCTP as substrate as dCMP, CTP, CDP, CMP, cytosine or deoxycytosine are not deaminated. While most bacteria require two enzymes to form dUMP from dCTP (EC 3.5.4.13, dCTP deaminase and EC 3.6.1.23, dUTP diphosphatase), the archaeon Methanocaldococcus jannaschii uses a single enzyme to carry out both functions. This enzyme can also act as a dUTP diphosphatase, but more slowly.
History
EC 3.5.4.30 created 2003
Pathway
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Orthology
K09887  dCTP deaminase (dUMP-forming)
Genes
CGAS: J1C67_08445
MJA: MJ_0430
MFE: Mefer_1292
MVU: Metvu_0792
MFS: MFS40622_1697
MIF: Metin_0912
MJH: JH146_1343
MESG: MLAUSG7_0719(dcd)
MESA: MLASG1_0125(dcd)
MIG: Metig_1531
MMP: MMP1426(dcd)
MMQ: MmarC5_0152
MMX: MmarC6_1247
MMZ: MmarC7_0671
MMD: GYY_07965
MMAK: MMKA1_16500(dcd)
MMAO: MMOS7_15330(dcd)
MMAD: MMJJ_14130(dcd)
MAE: Maeo_1411
MVN: Mevan_0737
MVO: Mvol_1036
MOK: Metok_0793
 » show all
Reference
1  [PMID:12538648]
  Authors
Li H, Xu H, Graham DE, White RH
  Title
The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase.
  Journal
J Biol Chem 278:11100-6 (2003)
DOI:10.1074/jbc.M212460200
  Sequence
[mja:MJ_0430]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.30
IUBMB Enzyme Nomenclature: 3.5.4.30
ExPASy - ENZYME nomenclature database: 3.5.4.30
BRENDA, the Enzyme Database: 3.5.4.30
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