KEGG   ENZYME: 3.5.99.5
Entry
EC 3.5.99.5                 Enzyme                                 
Name
2-aminomuconate deaminase;
amnD (gene name);
nbaF (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
Sysname
2-aminomuconate aminohydrolase
Reaction(IUBMB)
2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH3 [RN:R03887]
Reaction(KEGG)
R03887
Substrate
2-aminomuconate [CPD:C02220];
H2O [CPD:C00001]
Product
(3E)-2-oxohex-3-enedioate;
NH3 [CPD:C00014]
Comment
2-Aminomuconate is an intermediate in the bacterial biodegradation of nitrobenzene. The enzyme has been isolated from several species, including Pseudomonas pseudocaligenes JS45, Pseudomonas fluorescens KU-7, Pseudomonas sp. AP3 and Burkholderia cenocepacia J2315. The reaction is spontaneous in acid conditions.
History
EC 3.5.99.5 created 2000, modified 2012
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K15067  2-aminomuconate deaminase
Genes
SLQ: M495_05195
PMEX: H4W19_03330
PJP: LAG73_06430
LAB: LA76x_2546(amnD)
LAQ: GLA29479_1095(amnD)
LCP: LC55x_2796(amnD)
LGU: LG3211_2668(amnD)
LEZ: GLE_2674
LEM: LEN_2361
LMB: C9I47_1499
LYT: DWG18_05825
LUE: DCD74_03950
LYJ: FKV23_07535
LSOL: GOY17_11470
LSX: H8B22_00650
LARE: HIV01_004045
LHX: LYSHEL_30000
LCAS: LYSCAS_29970
LCIC: INQ41_07800
LAVI: INQ42_07235
LLZ: LYB30171_01461(amnD)
LAUX: LA521A_22240
LYA: RDV84_19000
LUM: CNR27_08230
LUS: E5843_08250
LUG: FPZ22_13385
THES: FHQ07_01255
THEH: G7079_08035
TCN: H9L16_12750
TBV: H9L17_01810
XBC: ELE36_12515
FSG: LQ771_09730
FED: LQ772_10980
RHD: R2APBS1_1169
RGL: CS053_05990
RTH: LRK53_07360
DJI: CH75_03330
DJA: HY57_09320
DYE: EO087_08405
DCS: ISN74_04650
DTL: H8F01_15800
DTA: DYST_01722
DKO: I596_660
LRZ: BJI69_00890
LPY: FIV34_14510
LANH: KR767_20490
LFL: IM816_12165
LAEO: L2Y97_15670
LAES: L2Y96_15485
XBA: C7S18_00565
PCQ: PcP3B5_23520(amnD)
PPW: PputW619_2009
PKC: PKB_3260(amnd1) PKB_3608(amnd3)
PSOS: POS17_2259
PSET: THL1_488
PSEP: C4K39_5745
PPII: QL104_12005
PTRT: HU722_0015020
PTAE: NCTC10697_02307(amnD)
PHF: NLY38_02345
PSOA: PSm6_34020
PKJ: Q1W70_06560
PAGR: E2H98_06040
SWD: Swoo_1409
SEUR: FM038_016460
COZ: A3Q34_02640
COLW: A3Q33_02675
COV: EKO29_05095
CBER: B5D82_03520
THT: E2K93_11180
THAB: LP316_08940
THAT: H3N35_10265
TACT: SG35_010850
TVD: SG34_018575
LAL: AT746_01270
SALH: HMF8227_02736(amnD)
MMAI: sS8_3505
MSZE: MSZNOR_2870
WMA: WM2015_1462
WOC: BA177_12680
HCS: FF32_08370
HBP: HPTD01_720
HALK: CUU95_03810
HVN: EI420_02120
PLEI: Q9312_09645
KKO: Kkor_0381
KGE: TQ33_1985
KSD: KS2013_2036
KPD: CW740_01645
KAM: SR900_00175
VMS: LVJ82_11895
CRZ: D1345_11505
CHAE: CH06BL_23580
AQS: DKK66_07200
RIN: ACS15_4681(amnD)
REU: Reut_B5501
RME: Rmet_5203 Rmet_5211(amnD)
CBW: RR42_m1051 RR42_m1060
CCUP: BKK81_23325
CUP: BKK80_32990
CUU: BKK79_23875
COX: E0W60_03795
BUR: Bcep18194_C7642
BCJ: BCAM2131(nbaF)
BCEO: I35_6013(nbaF)
BMUL: NP80_3863(amnD)
BSTL: BBJ41_33950
BARI: NLX30_35155
BUG: BC1001_3830
BXE: Bxe_A1148(amnD) Bxe_A1831
BXB: DR64_3307(amnD) DR64_3993(amnD)
BPX: BUPH_00405
BPY: Bphyt_1470
BFN: OI25_253
PTER: C2L65_38895
PBRY: NDK50_06190
PPAI: E1956_27320 E1956_31145
BRH: RBRH_03004
PPK: U875_06930
PPNO: DA70_24005
PPNM: LV28_06700
PRB: X636_02640
PPUL: RO07_00740
PSPU: NA29_10885
PAPI: SG18_00955
PVE: UC34_17035
POX: MB84_21815
PFG: AB870_04080
PNR: AT302_15070
PAND: DRB87_15745
PFIB: PI93_010950
PCOM: NTU39_18745
BAV: BAV0553(amnE)
BHZ: ACR54_00825(amnD_1)
BOJ: CBF45_16990
AXY: AXYL_05540
AXO: NH44784_030381
AXN: AX27061_5280
AXX: ERS451415_05309(amnD)
ADT: APT56_24285
AIS: BUW96_16330
ASW: CVS48_11360
ACHR: C2U31_27055
ACHB: DVB37_23450
ADY: HLG70_26340
APES: FOC84_18200
AAEG: RA224_05020
PUT: PT7_3612
PUD: G9Q38_14245
CDN: BN940_01151
PIG: EGT29_10810 EGT29_21575 EGT29_23055
KGY: EHF36_16930
PARK: LSG25_00270 LSG25_19440
NARM: N7E01_09430
POL: Bpro_5138
DIH: G7047_06940 G7047_08820
DRG: H9K76_22890 H9K76_22955
PKT: AT984_18825
HEE: hmeg3_08030 hmeg3_19575
AAK: AA2016_1095
ENP: JVX98_29990
NHUM: PQ457_19215
SMAG: AN936_00745
SMAZ: LH19_00755
STER: AOA14_03890
SGI: SGRAN_3550(amnD)
SPHO: C3E99_12565
SWI: Swit_3522
SPHD: HY78_06670
SPKC: KC8_11580
SYB: TZ53_02820
SUFL: FIL70_13985
SBAR: H5V43_15200
KSC: CD178_01496(amnD_1)
NCB: C0V82_23415
PAQI: KW060_12520
GSO: PH603_12385
MXA: MXAN_0920
MSD: MYSTI_00938
MYM: A176_006059
MFB: MFUL124B02_05275
MYX: QEG98_05300
CCX: COCOR_00870(tdcF)
MFU: LILAB_04110
MMAS: MYMAC_000942
SUR: STAUR_2724
AGE: AA314_01333
AVM: JQX13_18950
PCAY: FRD00_12785
BBAE: FRD01_10700
BDQ: CIK05_11250
MGO: AFA91_00025
CEE: CENDO_03485(amnD)
NTP: CRH09_30235
RER: RER_04720 RER_59350
REY: O5Y_02270
REB: XU06_02470
RQI: C1M55_02655
RHOD: AOT96_13020
RRT: 4535765_01256(amnD)
REQ: REQ_05060
PDEF: P9209_00355
GOC: CXX93_11300
GSI: P5P27_10830
TOY: FO059_00310
SANL: KZO11_33895
SCB: SCAB_15171(amnE)
SSX: SACTE_4112
STRT: A8713_24470
SVU: B1H20_29085
SGE: DWG14_08259(amnD_2)
SNK: CP967_06835
SSUB: CP968_28060
SPLA: CP981_35190
SCAL: I6J39_28935
SROI: IAG44_01275
SDRZ: NEH16_30285
STUD: STRTU_001642 STRTU_001673
MVD: AWU67_16695
AGY: ATC03_02575
AMAU: DSM26151_04160(amnD)
ASOI: MTP13_01925
LTR: EVS81_03250
ARZ: AUT26_08865
KFL: Kfla_5492
KQI: F1D05_11670
KSL: OG809_02125
ACTW: F7P10_40035
AGRA: AGRA3207_000778
AMAZ: LUW76_47890
ACIR: OG979_41950
SPIQ: OHA34_00550
SRO: Sros_9111
NOA: BKM31_47345
NCX: Nocox_40760(amnD)
NGN: LCN96_28050 LCN96_54775
NFS: OIE67_45795
FRI: FraEuI1c_1244
AMYC: CU254_17670
AROO: NQK81_00870
ARHD: VSH64_19095 VSH64_30300
KUT: JJ691_37140(amnD)
PMAD: BAY61_16760
STP: Strop_3523
SAQ: Sare_3898
MAU: Micau_4936
MIL: ML5_3359
MICB: MicB006_3968
MTUA: CSH63_33410
MTEM: GCE86_19375
MCAB: HXZ27_25035
VMA: VAB18032_17775 VAB18032_28736
MCRA: ID554_21675 ID554_30885
VER: HUT12_13550 HUT12_26045
MENO: Jiend_41050
MCHL: PVK74_15025
MFEU: H1D33_00375
MPRN: Q3V37_13165
MHAW: RMN56_18010
PLK: CIK06_22400
PFLA: Pflav_027510
PSUU: Psuf_082370
PRY: Prubr_10580 Prubr_59270
CATI: CS0771_01250
DFU: Dfulv_27710
DROS: Drose_21605
NHY: JQS43_06625
JCY: M6B22_15195
MFF: MFFC18_36450(amnD)
GES: VT84_05910(amnD)
GMS: SOIL9_56630
ABA: Acid345_0684
CTM: Cabther_A0369
CVL: J8C06_09220
CHLO: J8C02_01805
SCOR: J3U87_19660
PGO: FSB84_28990
HSW: Hsw_3527
HYM: N008_11740
HYD: PK28_15270
HYE: AM218_01200
HYG: AUC43_08340
HYH: D3Y59_16475
HYJ: FHG12_12060
HRS: HER32_07450
HBN: GUY19_17415
HTS: HMJ29_03665
HMT: MTP16_01815
HTB: MTX78_19080
HYK: O9Z63_13750
HSK: H4317_03835
HCW: O3303_11760
HSB: MWH26_14550
HCU: MUN79_28470
HVL: MUN86_18990
HCF: MUN80_00575
PKO: PKOR_08740
PACT: CA264_19620
RUF: TH63_01400
RTI: DC20_11895
RUD: TH61_09900
NIB: GU926_15625
MTT: Ftrac_3614
MHAA: Q3Y49_12270
CLIT: OQ292_08515
CHK: D4L85_04080
FUV: JR347_17250
CAT: CA2559_07405
KDI: Krodi_1917
DOK: MED134_12921
DDO: I597_1378(amnD)
DOD: DCS32_02245
LAN: Lacal_1455
LVN: BWR22_12895
LACI: CW733_09600
ASL: Aeqsu_0472
AEV: EI546_00340
AIC: JK629_01355
PSYD: IMZ30_02225
NDO: DDD_1880
NOM: AAT17_05195
NSD: BST91_00685
NOB: CW736_06510
NUL: R1T42_09545
POM: MED152_12764
POB: LPB03_06880
PRN: BW723_00745
POLA: BXQ17_06210
POA: CW731_07315
PHAL: H9I45_07190
PLIT: K8354_01545
PPEC: H9W90_08165
PBAT: JL193_14265
PCEA: J3359_06230
PHG: KCTC32516_00166(amnD)
WIN: WPG_2049
WIJ: BWZ20_05985
TEN: LPB136_00555
TJE: TJEJU_1408(amnD)
TMAR: MARIT_1043(amnD)
TMP: F9Y86_12500
TOV: PG911_13810
TRT: PG912_04805
TPAC: PG913_03410
TSIG: D6T69_12455
FOR: FORMB_05910
FOH: FORMA_06680
OLL: CW732_07065
OAQ: DZC78_13420
FEK: C1H87_06605
TAJ: C1A40_02555
AUE: C5O00_08950
KOS: KORDIASMS9_02220(amnD)
KAN: IMCC3317_39790(amnD)
MARF: CJ739_784
PSYN: E9099_03020
PPON: MUN68_001730
OCI: FEZ18_11755
MGEL: G5B37_13145
MESQ: C7H62_1605
ALTI: ALE3EI_0272
MARX: INR76_01205
SABU: MBM09_05735
BIA: GMA17_09780
FBE: FF125_14710
ALUT: O5O44_13180
AEST: RBH94_09735
MANG: RBH95_14595
HWS: RNZ46_10195
FBQ: D1817_12570
FTE: Fluta_1229
FLU: CHH17_16640
CRM: K6119_11800
OHO: Oweho_2577
CHYD: H4K34_08860
PTAN: CRYO30217_03027(amnD)
BBAU: AEM51_09070
 » show all
Reference
1  [PMID:9471964]
  Authors
He Z, Spain JC.
  Title
Studies of the catabolic pathway of degradation of nitrobenzene by Pseudomonas pseudoalcaligenes JS45: removal of the amino group from 2-aminomuconic semialdehyde.
  Journal
Appl Environ Microbiol 63:4839-43 (1997)
DOI:10.1128/AEM.63.12.4839-4843.1997
Reference
2  [PMID:9573204]
  Authors
He Z, Spain JC.
  Title
A novel 2-aminomuconate deaminase in the nitrobenzene degradation pathway of Pseudomonas pseudoalcaligenes JS45.
  Journal
J Bacteriol 180:2502-6 (1998)
DOI:10.1128/JB.180.9.2502-2506.1998
Reference
3  [PMID:11081795]
  Authors
Takenaka S, Murakami S, Kim YJ, Aoki K
  Title
Complete nucleotide sequence and functional analysis of the genes for 2-aminophenol metabolism from Pseudomonas sp. AP-3.
  Journal
Arch Microbiol 174:265-72 (2000)
DOI:10.1007/s002030000203
  Sequence
[ag:BAB03536]
Reference
4  [PMID:12620844]
  Authors
Muraki T, Taki M, Hasegawa Y, Iwaki H, Lau PC
  Title
Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomonas fluorescens strain KU-7.
  Journal
Appl Environ Microbiol 69:1564-72 (2003)
DOI:10.1128/AEM.69.3.1564-1572.2003
Other DBs
ExplorEnz - The Enzyme Database: 3.5.99.5
IUBMB Enzyme Nomenclature: 3.5.99.5
ExPASy - ENZYME nomenclature database: 3.5.99.5
BRENDA, the Enzyme Database: 3.5.99.5
CAS: 201098-29-5
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