KEGG   ENZYME: 4.1.1.74
Entry
EC 4.1.1.74                 Enzyme                                 
Name
indolepyruvate decarboxylase;
indol-3-yl-pyruvate carboxy-lyase;
3-(indol-3-yl)pyruvate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]
Reaction(IUBMB)
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2 [RN:R01974]
Reaction(KEGG)
R01974
Substrate
3-(indol-3-yl)pyruvate [CPD:C00331]
Product
2-(indol-3-yl)acetaldehyde [CPD:C00637];
CO2 [CPD:C00011]
Comment
Thiamine diphosphate- and Mg2+-dependent. More specific than EC 4.1.1.1 pyruvate decarboxylase
History
EC 4.1.1.74 created 1999
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K04103  indolepyruvate decarboxylase
Genes
STY: STY2646
STT: t0452
SEX: STBHUCCB_4850
SENT: TY21A_02305
STM: STM2405
SEO: STM14_2958
SEV: STMMW_24291
SEY: SL1344_2373
SEM: STMDT12_C24280
SEJ: STMUK_2436
SEB: STM474_2506
SEF: UMN798_2596
SETU: STU288_08415
SETC: CFSAN001921_04750
SENR: STMDT2_23731
SEND: DT104_24631
SENI: CY43_12870
SEEN: SE451236_18240
SPT: SPA0455
SEK: SSPA0422
SPQ: SPAB_00555
SEI: SPC_1250
SEC: SCH_2408(dciP)
SEH: SeHA_C2663
SHB: SU5_03012
SENH: CFSAN002069_19740
SEEH: SEEH1578_21365
SEE: SNSL254_A2597
SENN: SN31241_35150
SEW: SeSA_A2639
SEA: SeAg_B2548
SENS: Q786_11880
SEG: SG2441
SEL: SPUL_0473
SEGA: SPUCDC_0473
SET: SEN2391
SENA: AU38_12100
SENO: AU37_12115
SENV: AU39_12115
SENQ: AU40_13575
SENL: IY59_12435
SENJ: CFSAN001992_21525
SEEB: SEEB0189_007540
SENB: BN855_24940
SENE: IA1_12005
SENC: SEET0819_19470
SES: SARI_00479
SBG: SBG_2213
SBZ: A464_2540
SBV: N643_10720
SALZ: EOS98_06945
ENC: ECL_03728
ENL: A3UG_16365
ECLG: EC036_31850
ECLE: ECNIH2_16335
ECLN: ECNIH4_06815
ECLI: ECNIH5_15275
ECLX: LI66_15680
ECLY: LI62_17180
ECLZ: LI64_15110
ECLO: ENC_38590
EHM: AB284_09740
EXF: BFV63_15500
ECLA: ECNIH3_15365
ECLC: ECR091_15300
EAU: DI57_03295
EKB: BFV64_16045
ENO: ECENHK_15930
EEC: EcWSU1_03228(ipdC)
ELG: BH714_12275
ECAN: CWI88_06420(ipdC)
ERN: BFV67_15815
ECLS: LI67_017200
ECHG: FY206_17670(ipdC)
ESH: C1N69_16200(ipdC)
EPT: HWQ17_20045(ipdC)
ENT: Ent638_2923
EAS: Entas_3129
ENR: H650_07700
ENX: NI40_015950
ENF: AKI40_1502
LNI: CWR52_19090(ipdC)
EBG: FAI37_13135(ipdC)
END: A4308_20595
ENZ: G0034_16545(ipdC)
ENS: HWQ15_01260(ipdC)
ENK: LOC22_03820(ipdC)
EHU: D5067_0006810(ipdC)
EMOR: L6Y89_15500(ipdC)
ENB: ELK40_16340(ipdC)
EQU: OM418_15805(ipdC)
EPU: QVH39_16580(ipdC)
ESA: ESA_00851
CSK: ES15_1112(ipdC)
CSZ: CSSP291_04140
CSJ: CSK29544_02057
CCON: AFK62_14225
CDM: AFK67_14625
CSI: P262_01617
CMJ: AFK66_005195
CUI: AFK65_14100
CMW: AFK63_04175
CTU: CTU_29970(ipdC)
KPN: KPN_02740
KPU: KP1_3993
KPM: KPHS_38120
KPP: A79E_1361
KPH: KPNIH24_09625
KPZ: KPNIH27_18210
KPV: KPNIH29_19025
KPW: KPNIH30_19245
KPY: KPNIH31_18445
KPG: KPNIH32_19575
KPC: KPNIH10_18585
KPQ: KPR0928_18605
KPT: VK055_4773(ipdC)
KPO: KPN2242_16790
KPR: KPR_1964(ipdC)
KPJ: N559_1511
KPI: D364_13960
KPA: KPNJ1_01595
KPS: KPNJ2_01565
KPX: PMK1_00237(ipdC)
KPB: FH42_09815
KPNE: KU54_007350
KPNU: LI86_07355
KPNK: BN49_3956(ipdC)
KVA: Kvar_1310
KPE: KPK_1400(ipdC)
KPK: A593_03955
KVD: KR75_01250
KVQ: SP68_07780
KOX: KOX_26745
KOE: A225_4252
KOY: J415_10885
KOM: HR38_24875
KMI: VW41_16130
KOK: KONIH1_20955
KOC: AB185_15375
KQU: AVR78_23265
EAE: EAE_00275
EAR: CCG28866
KQV: B8P98_08020
KLL: BJF97_20915
KLW: DA718_08065
KAR: LGL98_06985
KGR: JJJ10_07820
KPAS: LUW96_27380
KLC: K7H21_07810
KLM: BWI76_20520
REE: electrica_01381(ipdC)
ROR: RORB6_00760
RON: TE10_20660
RPLN: B1209_06820
RAO: DSD31_07120
RTG: NCTC13098_01877(ipdC)
CRO: ROD_28081
CKO: CKO_00409
CFD: CFNIH1_23390
CBRA: A6J81_24390
CWE: CO701_05905
CYO: CD187_07330
CPOT: FOB25_18495
CFQ: C2U38_17710
CSED: JY391_07050
CAMA: F384_13285
CAF: AL524_10160
CIF: AL515_16230
CFAR: CI104_17990
CIR: C2U53_28235
CPAR: CUC49_12300
CTEL: GBC03_12025
CITZ: E4Z61_23790
CARS: E1B03_18930
CIX: M4I31_07160
CIB: HF677_007055
CENS: P2W74_06985
EBT: EBL_c11250
CNT: JT31_18750
CEM: LH23_22180
CEN: LH86_20710
CLAP: NCTC11466_01206(ipdC)
PGE: LG71_11480
ESC: Entcl_1355
KLE: AO703_15060
KSA: C813_22760
KOR: AWR26_07600
KRD: A3780_16360
KPSE: IP581_15955
KOO: O9K67_07425
KIE: NCTC12125_00318(ipdC)
KAS: KATP_12520
KLU: K7B04_22615
KCY: RIN60_06870
LAX: APT61_06465
LEI: C2U54_21570(ipdC)
LEH: C3F35_18455(ipdC)
LEE: DVA44_06580(ipdC)
LER: GNG29_16180(ipdC)
LEA: GNG26_16025(ipdC)
LPNU: KQ929_05630(ipdC)
LEY: DVA43_01310(ipdC)
LAZ: A8A57_15055
LEF: LJPFL01_2968
LEW: DAI21_11595(ipdC)
BUF: D8682_22045
BAGE: BADSM9389_11760
BFT: MNO13_06395
AHN: NCTC12129_01441(ipdC)
ASUB: NLZ15_15730
YRE: HEC60_11310
SGOE: A8O29_006725
IZH: FEM41_22835
PSHI: SAMEA2665130_1032(ipdC)
PSGC: G163CM_02450(ipdC)
TOE: QMG90_07075
EBF: D782_1263
EBU: CUC76_22595
EBB: F652_508
PSTS: E05_18610
YEN: YE1222(ipdC)
YEP: YE105_C2890
YEY: Y11_00891
YEW: CH47_624(ipdC)
YET: CH48_396
YEF: FORC2_1242
YEE: YE5303_09771(ipdC)
YAL: AT01_1826 AT01_3659
YRO: CH64_1327
YAK: ACZ76_03060
YMA: DA391_06555
YHI: D5F51_15485
YCA: F0T03_06850
YMO: HRD69_19045
YAS: N0H69_09555
YKI: HRD70_01145 HRD70_10990
YEG: PL78_16125
SMAR: SM39_3023
SMAC: SMDB11_2815
SMW: SMWW4_v1c35330
SPE: Spro_3412
SRR: SerAS9_3605
SRL: SOD_c33270(ipdC)
SRY: M621_18085
SPLY: Q5A_018035(ipdC_2)
SRS: SerAS12_3606
SRA: SerAS13_3607
SMAF: D781_3193
SLQ: M495_17545
SERF: L085_11020 L085_12715 L085_13395
SERS: SERRSCBI_17135
SFW: WN53_26400
SFG: AV650_22465
SRZ: AXX16_1876
SERM: CLM71_16870
SQU: E4343_23680
SFJ: SAMEA4384070_3544(ipdC_2)
SOF: NCTC11214_03262(ipdC_2)
SSUR: ATE40_014285
SURI: J0X03_06375
SRHZ: FO014_17375
SNEM: NLX84_17740
SNEV: OI978_14765 OI978_16570
SFO: Z042_04065
RAH: Rahaq_1125
RAQ: Rahaq2_1203
RAA: Q7S_05405
ROX: BV494_00920
RVC: J9880_13470
RBON: QNM34_05780
RIU: I2123_07690
GQU: AWC35_19130
EAME: GXP68_06180
RBAD: H2866_01975
RCB: O1V66_01350
CARU: P0E69_05605
NIG: C1N62_04595
ECA: ECA3605(ipdC)
PATR: EV46_17890
PATO: GZ59_36300(ipdC)
PCT: PC1_3426
PCC: PCC21_034320
PCV: BCS7_17265
PPOA: BJK05_12135
PBRA: B5S52_04525
PPUJ: E2566_17245(ipdC)
PARI: I2D83_04345(ipdC)
PVZ: OA04_36950(ipdC)
PPAV: LOZ86_04685(ipdC)
PCAC: OI450_13980
PACB: M9782_19525(ipdC)
DDC: Dd586_3014
CED: LH89_04805
DFN: CVE23_07930
BGJ: AWC36_00415
EAM: EAMY_2469(pdc3)
EAY: EAM_2375(ipdC)
ETA: ETA_11130(ipdC)
EPY: EpC_11610(ipdC)
EPR: EPYR_01238(pdc)
EBI: EbC_32520(ipdC)
ERJ: EJP617_35260(ipdC)
EPE: CI789_02120
ERWI: GN242_05845
ERP: LJN55_16735
ETO: RIN69_16145
PAM: PANA_2745(ipdC)
PLF: PANA5342_1305(ipdC)
PAJ: PAJ_2029(ipdC)
PAQ: PAGR_g1280
PVA: Pvag_2180(ipdC)
PAGG: AL522_17970(ipdC)
PAO: Pat9b_2818
KLN: LH22_08515
PANT: PSNIH1_00855
PANP: PSNIH2_03830
PAGC: BEE12_01535
PALH: B1H58_13165
PANS: FCN45_13640
PEY: EE896_05575(ipdC)
PDIS: D8B20_12140
PER: LAC65_11385
PJI: KTJ90_05525(ipdC)
PANO: OJ965_07855(ipdC)
KPIE: N5580_04940
PALF: K6R05_05630(ipdC)
PGZ: C2E15_15295
PCD: C2E16_14980
MINT: C7M51_02237(ipdC)
MTHI: C7M52_00620(ipdC)
MHAN: K6958_14410
TCI: A7K98_17870
PMR: PMI0845(ipdC)
PMIB: BB2000_0963(ipdC)
PVL: AOB99_06655
PVG: CRN77_14965
PHAU: PH4a_13540
PROT: BTA34_05370
PCOL: F1325_07190
PCIB: F9282_07080
PPEE: I6G31_02940
PSI: S70_05510 S70_19930
PSX: DR96_214 DR96_2898
PSTA: BGK56_01980 BGK56_08375
PTHA: OI982_03415 OI982_18295
PRG: RB151_020410(ipdC)
PALA: CO695_08990 CO695_09005
PHEI: NCTC12003_00975(ipdC_1) NCTC12003_02564(ipdC_2)
PRQ: CYG50_07000 CYG50_21130
PRJ: NCTC6933_03065(ipdC_1) NCTC6933_03068(ipdC_2)
PVC: G3341_04665 G3341_11360
PMAG: JI723_11240 JI723_13475
PHAG: PZ638_04790 PZ638_11900
MMK: MU9_3137
EIC: NT01EI_0305 NT01EI_1772
ETR: ETAE_1930
ETD: ETAF_1742
ETE: ETEE_4006(ipdC)
ETC: ETAC_08820
EDW: QY76_10580
EDL: AAZ33_09865
EHO: A9798_15120
HAV: AT03_07360
HPAR: AL518_18225
OPO: DSM2777_12635
DYE: EO087_06490
VNI: VIBNI_B0089
POI: BOP93_20470
PEN: PSEEN2115
PSAM: HU731_009640
PANH: HU763_022815
PMAM: KSS90_10950
PAGR: E2H98_15195
SAZ: Sama_1025
SKH: STH12_00564(ipdC)
SLIT: JQC75_04935
IDI: CWC33_04800
IAB: K5X84_00755
CPS: CPS_0688
PRR: AT705_06545
PLZ: S4054249_14100 S4054249_16175
PALN: B0W48_00215
PPIS: B1L02_22865
PSEN: PNC201_21925(ipdC)
PVB: J5X90_08120 J5X90_18170
PFLI: CTT31_23575
PMAZ: R5H13_23720
LAL: AT746_07025
CATE: C2869_18270
PMAW: MACH26_07870
SAGA: M5M_04875
FTU: FTT_1744c(ipdC)
FTQ: RO31_2075
FTF: FTF1744c(ipdC)
FTW: FTW_1982
FTR: NE061598_10155
FTT: FTV_1661(ipdC)
FTG: FTU_1746(ipdC)
FTL: FTL_0006
FTS: F92_00035
FTO: X557_00040
FTC: DA46_736
FTV: CH67_257
FTZ: CH68_2141
FTM: FTM_1730(idpC)
FTN: FTN_0116(ipdC)
FTX: AW25_84
FTD: AS84_598
FTY: CH70_10
FCF: FNFX1_0108
FCN: FN3523_0100
FHI: FSC454_00480
FPH: Fphi_0711
FPT: BZ13_1316
FPI: BF30_920
FPM: LA56_1459
FPX: KU46_635
FPZ: LA55_89
FPJ: LA02_567
FRT: F7308_0106
FRX: F7310_00570
FRC: KX01_410
FAD: CDH04_05840
FMI: F0R74_08965
FSR: KQR59_00530
FRL: FIP56_00530
TSY: THSYN_15535
RHH: E0Z06_09145
THIP: N838_27840 N838_29260
SEDS: AAY24_06235
HCH: HCH_01981
HAHE: ENC22_20920
HAHH: O5O45_16555
ENW: MJO57_30755
SUTR: L0B52_07745(ipdC)
MAER: DAI18_11795
PDIO: PDMSB3_1977.1
BOJ: CBF45_08145
KGY: EHF36_08290
RFR: Rfer_0518
RHOA: HZ993_13435(ipdC)
COF: FOZ74_12250(ipdC)
OTD: J1M35_15580(ipdC)
SIMP: C6571_06705(ipdC)
MNR: ACZ75_02305
MASY: DPH57_05430(ipdC)
MENY: LSQ66_21965(ipdC)
MASZ: C9I28_16430(ipdC)
MFLA: GO485_02350(ipdC)
EHB: E7V67_014380(ipdC)
UPL: DSM104440_01061(ipdC)
ARES: IWH25_13915(ipdC)
EBA: ebA6545(pdc)
ABRE: pbN1_40400(pdC)
APET: ToN1_46880(pdc)
AZA: AZKH_2996(ipdC)
AZI: AzCIB_1933
AZD: CDA09_11830(ipdC)
TMZ: Tmz1t_0101
TCL: Tchl_0074
TAK: Tharo_0060
APP: CAP2UW1_2653
KMN: HW532_21720(ipdC)
SMK: Sinme_5681
SMQ: SinmeB_5928
SMD: Smed_5992 Smed_6051
RET: RHE_PF00449
REC: RHECIAT_PC0000672
REL: REMIM1_PF00428
REP: IE4803_PC00499
REI: IE4771_PD00509
RLU: RLEG12_10425
RGA: RGR602_PC00349
RHN: AMJ98_PE00527
RPHA: AMC79_PD00665
RHK: Kim5_PC00457
REZ: AMJ99_PD00527
RHID: FFM81_025020
RLN: J0663_24040
RBAN: J2J98_22780
RRG: J3P73_25215
RAW: NE851_33400
RSUL: N2599_34600
RLW: RlegWSM1455_25830
BRA: BRADO7016(ipdC)
BBT: BBta_0512(ipdC)
AOL: S58_04790
BRO: BRAD285_7156(ipdC)
BGZ: XH91_10085
RPA: TX73_016115(ipdC)
RPB: RPB_2425
RPD: RPD_3027
RPT: Rpal_3526
RPX: Rpdx1_2308
STAR: G3545_10560
SNO: Snov_3860
BID: Bind_1794
CMB: CSW64_09035
TRY: QF118_13330
PAMO: BAR1_13915(ipdC)
SPHS: ETR14_13725
ERR: DVR09_08065(ipdC)
ABG: Asbog_00347
BOB: GN304_01255 GN304_01565
PARZ: DTQ13_05850
RAP: RHOA_2015(ipdC)
ABS: AZOBR_40354(ipdC)
ABQ: ABAZ39_11295
ABF: AMK58_11540
AZT: TSH58p_08865(ipdC)
AARE: D3093_12380(ipdC)
NCB: C0V82_11605
RRU: Rru_A2719
RRF: F11_13965
DVN: HQ394_02155
HTL: HPTL_0792
DMA: DMR_26260
DCB: C3Y92_12130
DDE: Dde_2331
DSA: Desal_2664
DAS: Daes_0883
DVM: DvMF_0027
CLIH: KPS_000038(ipdC)
DPS: DP2330
APAU: AMPC_29240
LLU: AKJ09_08048
BCG: BCG9842_B2896
BTN: BTF1_09505
BWE: BcerKBAB4_2434
BWW: bwei_2395(PDC5)
BMYC: DJ92_4749
BWD: CT694_29840
BNT: GSN03_12745
BLE: BleG1_3106
BSJ: UP17_04570
BMUR: ABE28_004740
PFRI: L8956_04930
SALE: EPH95_05810
BVJ: I5776_11475
GAJ: MY490_06055
STEA: C0679_01880
SSCZ: RN70_02275
SLZ: B5P37_04325
SCHR: DWB92_02035
SFF: FOB90_05805
PBV: AR543_06930
PYG: AWM70_15780
COHN: KCTCHS21_12950(pdc)
SACA: FFV09_15190
CPAS: Clopa_0520
CPAT: CLPA_c04400(kdc)
CPAE: CPAST_c04400(kdc)
MSTO: MSTO_33270
MSAK: MSAS_54240
MKU: I2456_01155
MAUU: NCTC10437_03502(pdc)
MTY: MTOK_57060(pdc1)
MSEI: MSEDJ_11710
SGV: B1H19_03900
SFY: GFH48_00745
SRIM: CP984_14945
SBRO: GQF42_35885
SCAL: I6J39_02285
SACT: DMT42_01490
SCOA: QU709_37660
AGLA: OIE69_03795 OIE69_35025
ACIT: HPK19_08900
NGV: CDO52_11105
NGN: LCN96_39405
FRI: FraEuI1c_3511
KRA: Krad_0182
ACTY: OG774_28575
SAQ: Sare_0838
AMS: AMIS_17220
SYG: sync_1491
SYX: SynWH7803_0869(pdc)
SYND: KR52_11410
CAN: Cyan10605_1896
CAP: CLDAP_36720
KBB: ccbrp13_33530
SACI: Sinac_1424
AGV: OJF2_34230(ipdC_2)
PCOR: KS4_35060(ipdC)
CPI: Cpin_1754
CHIH: GWR21_24215
CFIL: MYF79_08810
CSAC: SIO70_07755
ARAC: E0W69_007350
MUC: MuYL_0601
ALGO: GYM62_19425
FJO: Fjoh_3836
AQB: D1818_21015
AFLA: FHG64_17570
MBA: Mbar_A1429
MBY: MSBRM_0475
MBW: MSBRW_3298
MBAR: MSBR2_1907
MBAK: MSBR3_2046
MAC: MA_0594(ipdC)
MVC: MSVAZ_0537
MEK: MSKOL_0516
MTHR: MSTHT_2109
MTHE: MSTHC_1175
MHOR: MSHOH_3634
MFZ: AOB57_005405
 » show all
Reference
1  [PMID:7766676]
  Authors
Koga J.
  Title
Structure and function of indolepyruvate decarboxylase, a key enzyme in indole-3-acetic acid biosynthesis.
  Journal
Biochim Biophys Acta 1249:1-13 (1995)
DOI:10.1016/0167-4838(95)00011-I
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.74
IUBMB Enzyme Nomenclature: 4.1.1.74
ExPASy - ENZYME nomenclature database: 4.1.1.74
BRENDA, the Enzyme Database: 4.1.1.74
CAS: 9074-92-4
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