Entry
Name
benzylsuccinate synthase;
benzylsuccinate fumarate-lyase
Class
Lyases;
Carbon-carbon lyases;
Other carbon-carbon lyases
BRITE hierarchy
Sysname
benzylsuccinate fumarate-lyase (toluene-forming)
Reaction(IUBMB)
benzylsuccinate = toluene + fumarate [RN:
R05598 ]
Reaction(KEGG)
Substrate
Product
Comment
A glycyl radical enzyme that is inhibited by benzyl alcohol, benzaldehyde, phenylhydrazine and is inactivated by oxygen.
History
EC 4.1.99.11 created 2000
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K07540 benzylsuccinate synthase
Genes
EBA : c2A303(bssC) c2A304(bssA) c2A305(bssB)
APET : ToN1_01380(bssC) ToN1_01390(bssA) ToN1_01400(bssB)
AZI : AzCIB_4504 AzCIB_4505 AzCIB_4506
AZD : CDA09_07530 CDA09_07535 CDA09_21890 CDA09_21895
TCL : Tchl_1404 Tchl_1405 Tchl_1406
TAK : Tharo_3069 Tharo_3070 Tharo_3071
GME : Gmet_1538(bssB) Gmet_1539(bssA) Gmet_1540(bssC)
GEO : Geob_2437(bssB-2) Geob_2438(bssA-2) Geob_2439(bssC-2) Geob_2447(bssB-1) Geob_2448(bssA-1) Geob_2449(bssC-1)
DTO : TOL2_C01390(bssB) TOL2_C01400(bssA) TOL2_C01410(bssC)
DOV : DSCO28_00220 DSCO28_15650 DSCO28_65240(pflD_2)
DMM : dnm_089690(hbsB) dnm_089710(hbsC)
DGI : Desgi_0659 Desgi_0660
» show all
Taxonomy
Reference
Authors
Beller HR, Spormann AM.
Title
Analysis of the novel benzylsuccinate synthase reaction for anaerobic toluene activation based on structural studies of the product.
Journal
Reference
Authors
Leuthner B, Leutwein C, Schulz H, Horth P, Haehnel W, Schiltz E, Schagger H, Heider J
Title
Biochemical and genetic characterization of benzylsuccinate synthase from Thauera aromatica: a new glycyl radical enzyme catalysing the first step in anaerobic toluene metabolism.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.1.99.11
UM-BBD (Biocatalysis/Biodegradation Database): 4.1.99.11
LinkDB
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