KEGG   ENZYME: 4.1.99.11
Entry
EC 4.1.99.11                Enzyme                                 
Name
benzylsuccinate synthase;
benzylsuccinate fumarate-lyase
Class
Lyases;
Carbon-carbon lyases;
Other carbon-carbon lyases
Sysname
benzylsuccinate fumarate-lyase (toluene-forming)
Reaction(IUBMB)
benzylsuccinate = toluene + fumarate [RN:R05598]
Reaction(KEGG)
R05598
Substrate
benzylsuccinate [CPD:C09816]
Product
toluene [CPD:C01455];
fumarate [CPD:C00122]
Comment
A glycyl radical enzyme that is inhibited by benzyl alcohol, benzaldehyde, phenylhydrazine and is inactivated by oxygen.
History
EC 4.1.99.11 created 2000
Pathway
ec00623  Toluene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K07540  benzylsuccinate synthase
Genes
EBAc2A303(bssC) c2A304(bssA) c2A305(bssB)
APETToN1_01380(bssC) ToN1_01390(bssA) ToN1_01400(bssB)
AZIAzCIB_4504 AzCIB_4505 AzCIB_4506
AZDCDA09_07530 CDA09_07535 CDA09_21890 CDA09_21895
TCLTchl_1404 Tchl_1405 Tchl_1406
TAKTharo_3069 Tharo_3070 Tharo_3071
GMEGmet_1538(bssB) Gmet_1539(bssA) Gmet_1540(bssC)
GEOGeob_2437(bssB-2) Geob_2438(bssA-2) Geob_2439(bssC-2) Geob_2447(bssB-1) Geob_2448(bssA-1) Geob_2449(bssC-1)
DALDalk_2198
DTOTOL2_C01390(bssB) TOL2_C01400(bssA) TOL2_C01410(bssC)
DOVDSCO28_00220 DSCO28_15650 DSCO28_65240(pflD_2)
DWDDSCW_52810
DALKDSCA_19210
DMMdnm_089690(hbsB) dnm_089710(hbsC)
DGIDesgi_0659 Desgi_0660
 » show all
Reference
1  [PMID:9765580]
  Authors
Beller HR, Spormann AM.
  Title
Analysis of the novel benzylsuccinate synthase reaction for anaerobic toluene activation based on structural studies of the product.
  Journal
J Bacteriol 180:5454-7 (1998)
DOI:10.1128/JB.180.20.5454-5457.1998
Reference
2  [PMID:9632263]
  Authors
Leuthner B, Leutwein C, Schulz H, Horth P, Haehnel W, Schiltz E, Schagger H, Heider J
  Title
Biochemical and genetic characterization of benzylsuccinate synthase from Thauera aromatica: a new glycyl radical enzyme catalysing the first step in anaerobic toluene metabolism.
  Journal
Mol Microbiol 28:615-28 (1998)
DOI:10.1046/j.1365-2958.1998.00826.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.99.11
IUBMB Enzyme Nomenclature: 4.1.99.11
ExPASy - ENZYME nomenclature database: 4.1.99.11
UM-BBD (Biocatalysis/Biodegradation Database): 4.1.99.11
BRENDA, the Enzyme Database: 4.1.99.11
CAS: 209264-18-6
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