| Entry |
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| Name |
2-hydroxyisoflavanone dehydratase;
2,7,4'-trihydroxyisoflavanone hydro-lyase;
2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
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| Reaction(IUBMB) |
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN: R07317];
(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
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| Reaction(KEGG) |
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| Substrate |
2,4',7-trihydroxyisoflavanone [CPD: C15567];
2,4',5,7-tetrahydroxyisoflavanone [CPD: C12631]
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| Product |
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| Comment |
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
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| History |
EC 4.2.1.105 created 2004, modified 2013
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K13258 | 2-hydroxyisoflavanone dehydratase |
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| Genes |
| GMX: | 100785409 547489(HIDH) |
| PVU: | PHAVU_002G047500g PHAVU_007G054200g |
| CCAJ: | 109791254 109794824 109801193 109801222 |
| APRC: | 113870130 113871120 |
| TPRA: | 123882884 123909768 |
| PSAT: | 127076827 127097146 |
| LJA: | Lj5g3v2057520.1(Lj5g3v2057520.1) |
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| Reference |
1 |
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| Authors |
Hakamatsuka, T., Mori, K., Ishida, S., Ebizuka, Y and Sankawa, U. |
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| Title |
Purification of 2-hydroxyisoflavanone dehydratase from the cell cultures of Pueraria lobata. |
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| Journal |
Phytochemistry 49:497-505 (1998) |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 4.2.1.105 |
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| LinkDB |
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