KEGG   ENZYME: 4.2.1.30
Entry
EC 4.2.1.30                 Enzyme                                 
Name
glycerol dehydratase;
glycerol dehydrase;
glycerol hydro-lyase;
dhaB (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
glycerol hydro-lyase (3-hydroxypropanal-forming)
Reaction(IUBMB)
glycerol = 3-hydroxypropanal + H2O [RN:R01047]
Reaction(KEGG)
R01047
Substrate
glycerol [CPD:C00116]
Product
3-hydroxypropanal [CPD:C00969];
H2O [CPD:C00001]
Comment
Two different forms of the enzyme have been described. One form requires a cobamide cofactor, while the other is a glycyl radical enzyme.
History
EC 4.2.1.30 created 1972
Pathway
ec00561  Glycerolipid metabolism
Orthology
K06120  glycerol dehydratase large subunit
K06121  glycerol dehydratase medium subunit
K06122  glycerol dehydratase small subunit
Genes
ECLN: ECNIH4_18090 ECNIH4_18095 ECNIH4_18100(pduC)
ECHG: FY206_05715 FY206_05720 FY206_05725
KPN: KPN_03487(dhaB3) KPN_03488(dhaB2) KPN_03489(dhaB1)
KPU: KP1_4780(dhaB3) KP1_4781(dhaB2) KP1_4782(dhaB1)
KPM: KPHS_46170 KPHS_46180 KPHS_46190
KPP: A79E_0629 A79E_0630 A79E_0631
KPH: KPNIH24_05795(pduC) KPNIH24_05800 KPNIH24_05805
KPZ: KPNIH27_22045 KPNIH27_22050 KPNIH27_22055(pduC) KPNIH27_28305 KPNIH27_28310 KPNIH27_28315(pduC)
KPV: KPNIH29_22935 KPNIH29_22940 KPNIH29_22945(pduC)
KPW: KPNIH30_23260 KPNIH30_23265 KPNIH30_23270(pduC)
KPY: KPNIH31_22445 KPNIH31_22450 KPNIH31_22455(pduC)
KPG: KPNIH32_24110 KPNIH32_24115 KPNIH32_24120(pduC)
KPC: KPNIH10_22995 KPNIH10_23000 KPNIH10_23005(pduC)
KPQ: KPR0928_22515 KPR0928_22520 KPR0928_22525(pduC)
KPT: VK055_3981(dhaB) VK055_3982(gldB) VK055_3983(dhaB3)
KPO: KPN2242_20520(pduE) KPN2242_20525(pduD) KPN2242_20530(pduC)
KPR: KPR_4690(dhaE) KPR_4691 KPR_4692(dhaB)
KPJ: N559_0687 N559_0688 N559_0689
KPI: D364_17960(pduE) D364_17965 D364_17970(pduC)
KPA: KPNJ1_00673 KPNJ1_00674 KPNJ1_00675
KPS: KPNJ2_00715 KPNJ2_00716 KPNJ2_00717
KPX: PMK1_01004(pduE_2) PMK1_01005(pduD_2) PMK1_01006(dhaB)
KPB: FH42_13710 FH42_13715 FH42_13720(pduC)
KPNE: KU54_003315(pduC) KU54_003320 KU54_003325
KPNU: LI86_03320(pduC) LI86_03325 LI86_03330
KPNK: BN49_0619(dhaB) BN49_0620(dhaC) BN49_0621(dhaE)
KPE: KPK_0626(dhaB) KPK_0627(dhaC) KPK_0628(dhaE)
KVQ: SP68_11580 SP68_11585 SP68_11590(pduC)
KOM: HR38_29250(pduC) HR38_29255 HR38_29260
KOK: KONIH1_05900(pduC) KONIH1_05905 KONIH1_05910
KQV: B8P98_03370(pduC) B8P98_03375 B8P98_03380
KLW: DA718_03870(pduC) DA718_03875(pduD) DA718_03880(pduE)
KAR: LGL98_03220 LGL98_03225 LGL98_03230
RTG: NCTC13098_04657(pduE) NCTC13098_04661(dhaB_1)
CFD: CFNIH1_02600 CFNIH1_02605 CFNIH1_02610(pduC)
CBRA: A6J81_20560(pduC) A6J81_20565 A6J81_20570
CWE: CO701_01140(pduC) CO701_01145 CO701_01150
CYO: CD187_03220(pduC) CD187_03225 CD187_03230
CPOT: FOB25_14580 FOB25_14585 FOB25_14590
CFQ: C2U38_22190 C2U38_22195 C2U38_22200(pduC)
CIF: AL515_20230 AL515_20235 AL515_20240(pduC)
CIR: C2U53_02085(pduC) C2U53_02090 C2U53_02095
CIE: AN232_07885(pduC) AN232_07890 AN232_07895
CPAR: CUC49_15950 CUC49_15955 CUC49_15960(pduC)
CTEL: GBC03_00050 GBC03_00055 GBC03_00060 GBC03_27375 GBC03_27380 GBC03_27385
CITZ: E4Z61_20220 E4Z61_20225 E4Z61_20230
CARS: E1B03_22795(pduE) E1B03_22800(pduD) E1B03_22805(pduC)
CIX: M4I31_03305 M4I31_03310 M4I31_03315
CIB: HF677_003065 HF677_003070 HF677_003075
EBT: EBL_c29700(dhaE) EBL_c29710 EBL_c30180(dhaB)
PGE: LG71_13150 LG71_13155 LG71_13160(pduC)
LEF: LJPFL01_3596 LJPFL01_3597 LJPFL01_3598
BUF: D8682_25830(pduC) D8682_25835(pduD) D8682_25840(pduE)
METY: MRY16398_51760 MRY16398_51770 MRY16398_51780
TOE: QMG90_16905 QMG90_16910 QMG90_16915
EBC: C2U52_01540 C2U52_01545 C2U52_01550(pduC)
CPE: CPE0929 CPE0930 CPE0931
CPF: CPF_1173(dhaB) CPF_1174(dhaC) CPF_1175(dhaE)
CPR: CPR_1004(dhaB) CPR_1005(dhaC) CPR_1006(dhaE)
CBK: CLL_A2103 CLL_A2104 CLL_A2105
CBT: CLH_1940 CLH_1941 CLH_1942
CPAT: CLPA_c22790(pduE) CLPA_c22800(pduD) CLPA_c22810(dhaB)
CPAE: CPAST_c22790(pduE) CPAST_c22800(pduD) CPAST_c22810(dhaB)
CBV: U729_91(dhaB3) U729_92(gldB) U729_93(dhaB)
CGAS: J1C67_12780 J1C67_12785 J1C67_12790
THYR: P4S50_02370 P4S50_02375 P4S50_02380
IPO: Ilyop_1292 Ilyop_1293 Ilyop_1294
CSOM: MKD34_11385 MKD34_11390 MKD34_11395
 » show all
Reference
1  [PMID:14039344]
  Authors
SMILEY KL, SOBOLOV M.
  Title
A cobamide-requiring glycerol dehydrase from an acrolein-forming Lactobacillus.
  Journal
Arch Biochem Biophys 97:538-43 (1962)
DOI:10.1016/0003-9861(62)90118-2
Reference
2  [PMID:5962440]
  Authors
Schneider Z, Pawelkiewicz J.
  Title
The properties of glycerol dehydratase isolated from Aerobacter aerogenes, and the properties of the apoenzyme subunits.
  Journal
Acta Biochim Pol 13:311-28 (1966)
Reference
3  [PMID:4989992]
  Authors
Schneider Z, Larsen EG, Jacobson G, Johnson BC, Pawelkiewicz J.
  Title
Purification and properties of glycerol dehydrase.
  Journal
J Biol Chem 245:3388-96 (1970)
Reference
4  [PMID:7035429]
  Authors
Forage RG, Foster MA.
  Title
Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases.
  Journal
J Bacteriol 149:413-9 (1982)
DOI:10.1128/JB.149.2.413-419.1982
Reference
5  [PMID:15096031]
  Authors
O'Brien JR, Raynaud C, Croux C, Girbal L, Soucaille P, Lanzilotta WN
  Title
Insight into the mechanism of the B12-independent glycerol dehydratase from Clostridium butyricum: preliminary biochemical and structural characterization.
  Journal
Biochemistry 43:4635-45 (2004)
DOI:10.1021/bi035930k
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.30
IUBMB Enzyme Nomenclature: 4.2.1.30
ExPASy - ENZYME nomenclature database: 4.2.1.30
BRENDA, the Enzyme Database: 4.2.1.30
CAS: 9077-68-3
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