Entry
Name
pseudouridylate synthase;
pseudouridylic acid synthetase;
pseudouridine monophosphate synthetase;
5-ribosyluracil 5-phosphate synthetase;
pseudouridylate synthetase;
upsilonUMP synthetase;
uracil hydro-lyase (adding D-ribose 5-phosphate);
YeiN;
pseudouridine-5'-phosphate glycosidase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)
Reaction(IUBMB)
uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O [RN:
R01055 ]
Reaction(KEGG)
Substrate
Product
Comment
The reaction it readily reversible. While the enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate the enzyme from Escherichia coli functions as a pseudouridine-5'-phosphate glycosidase in vivo [5].
History
EC 4.2.1.70 created 1978
Pathway
Orthology
K16329 pseudouridylate synthase
K16330 pseudouridylate synthase / pseudouridine kinase
Genes
PTET : 122330306(zgc:136858)
PPRM : 120469112(zgc:136858)
MAMB : 125246783(zgc:136858)
SMEO : 124385728(zgc:136858)
TFD : 113635908(zgc:136858)
CMAO : 118806779(zgc:136858)
CHAR : 105913397(zgc:136858)
TBEN : 117494994(zgc:136858)
PGEO : 117447694(zgc:136858)
GACU : 117547894(zgc:136858)
ELY : 117261663(zgc:136858)
PLEP : 121949721(zgc:136858)
SLUC : 116038695(zgc:136858)
ECRA : 117949420(zgc:136858)
GAT : 120809115(zgc:136858)
PPUG : 119196684(zgc:136858)
CLUM : 117732229(zgc:136858)
MSAM : 119887135 119893481(zgc:136858)
SCHU : 122874866(zgc:136858)
CUD : 121515440(zgc:136858)
ALAT : 119023924(zgc:136858)
OAU : 116332693(zgc:136858)
OML : 112152316(zgc:136858)
GAF : 122835785(zgc:136858)
CTUL : 119799116(zgc:136858)
GMU : 124878451(zgc:136858)
KMR : 108230163(zgc:136858)
NWH : 119415841(zgc:136858)
MCEP : 125015233(zgc:136858)
SSEN : 122775917(zgc:136858)
HHIP : 117763051(zgc:136858)
HSP : 118110032(zgc:136858)
SMAU : 118315016(zgc:136858)
XGL : 120793174(zgc:136858)
OTW : 112218904(zgc:136858)
OMY : 110500088(zgc:136858)
OGO : 124032784(zgc:136858)
SNH : 120066470(zgc:136858)
CCLU : 121531625(zgc:136858)
AANG : 118218797(zgc:136858)
PSPA : 121317836(zgc:136858)
ARUT : 117419920(zgc:136858)
PSEX : 120539689(zgc:136858)
CMK : 103181812(zgc:136858)
CPLA : 122559599(zgc:136858)
DSI : Dsimw501_GD23033(Dsim_GD23033)
MDE : 101889080 101899870 101900038
SCAC : 106093779 106095136
AALB : 109415332 109423702 115261020
APLN : 108733691 108733740
MSEX : 115448982 119191425
CLEC : 106664206 112127808
BROR : 134531833 134532271
PPOI : 119103226 119103227
CEL : CELE_T24C12.3(T24C12.3)
CRQ : GCK72_013022 GCK72_023982
LGI : LOTGIDRAFT_176731 LOTGIDRAFT_221393
CSAT : 104742584 104758360 104777981
BNA : 106402769 106402924 106412011 106451661 125608522
MINC : 123205881 123225073
LJA : Lj3g3v0461700.1(Lj3g3v0461700.1)
SSPL : 121746396 121750138
SHIS : 125187116 125188222
PSOM : 113348462 113348901
DOSA : Os08t0504400-01(Os08g0504400)
TAES : 123084704 123093400 123098675
PVIR : 120649025 120687425
SMO : SELMODRAFT_234513 SELMODRAFT_35355 SELMODRAFT_413362 SELMODRAFT_413373
MPP : MICPUCDRAFT_61652(JGI:MicpuC2_61652)
DHA : DEHA2F00880g DEHA2F00902g
LEL : PVL30_003776 PVL30_003777
CAL : CAALFM_C307910WA(CaO19.6185) CAALFM_C307920WA
YLI : YALI0D11660g YALI0D11682g
SLB : AWJ20_1190 AWJ20_1192
NTE : NEUTE1DRAFT150742(NEUTE1DRAFT_150742)
APUU : APUU_10257A APUU_80577S
CCAC : CcaHIS019_0206120(CcaverHIS019_0206120)
ABP : AGABI1DRAFT110531(AGABI1DRAFT_110531)
ABV : AGABI2DRAFT189568(AGABI2DRAFT_189568)
SCM : SCHCO_02612260(SCHCODRAFT_02612260)
SLA : SERLADRAFT_433061 SERLADRAFT_444897
EHI : EHI_149860(270.t00006)
SMIN : v1.2.003813.t1(symbB.v1.2.003813.t1)
PTI : PHATRDRAFT_9211 PHATRDRAFT_9308
SPAR : SPRG_14104 SPRG_15227
EHX : EMIHUDRAFT_469948 EMIHUDRAFT_67520
ECOO : ECRM13514_2927(yeiN)
ECOH : ECRM13516_2867(yeiN)
ECT : ECIAI39_2305(yeiN) ECIAI39_4228(yeiN)
EOC : CE10_2537(psuG) CE10_4264
EDJ : ECDH1ME8569_2101(yeiN)
ECOI : ECOPMV1_02325(psuG)
METY : MRY16398_16950(psuG)
PLUM : A4R40_10970 A4R40_21555
PTT : VY86_05505 VY86_20060
SCAA : TUM17387_21240(psuG)
LLG : 44548918_01862(psuG)
LJR : NCTC11533_02005(psuG)
LCJ : NCTC11976_01047(indA)
LWA : SAMEA4504053_1335(psuG)
LSS : NCTC12082_00014(psuG_1) NCTC12082_03135(psuG_2)
LANT : TUM19329_11290(psuG)
GAI : IMCC3135_07080(psuG)
AEL : NCTC12917_00930(psuG)
SFD : USDA257_c40750(psuG)
AVV : RvVAT039_00570(psuG)
AVF : RvVAR031_21790(psuG)
REL : REMIM1_CH02336(psuG)
REP : IE4803_CH02367(psuG)
REI : IE4771_CH02454(psuG)
RGA : RGR602_CH02115(psuG)
RPHA : AMC79_CH02452(psuG)
NEN : NCHU2750_47730(psuG)
METS : DK389_19530 DK389_19750 DK389_28665
SINL : DSM14862_01417(psuG)
SPSE : SULPSESMR1_01606(psuG)
AHT : ANTHELSMS3_03412(psuG)
LVS : LOKVESSMR4R_01494(psuG)
NAO : Y958_03975 Y958_05730
AVM : JQX13_29165 JQX13_37730
BACA : FAY30_05180 FAY30_22900
NMK : CHR53_03250 CHR53_04285
SAUT : SAI1T1_2002380(psuG)
SAUJ : SAI2T2_1002380(psuG)
SAUK : SAI3T3_1002380(psuG)
SAUQ : SAI4T8_1002380(psuG)
SAUV : SAI7S6_1002380(psuG)
SAUW : SAI5S5_1002370(psuG)
SAUX : SAI6T6_1002380(psuG)
SAUY : SAI8T7_1002380(psuG)
SSH : NCTC13712_00260(psuG)
SSIM : SAMEA4384339_0251(psuG)
SSTE : SAMEA4384403_1745(psuG)
BRUM : NDK47_02115 NDK47_02530
SMEN : SAMEA4412692_1960(psuG)
ECEC : NCTC12421_02113(psuG)
VFA : MM35RIKEN_13740(psuG)
VCOP : MM50RIKEN_16330(psuG)
CSCI : HDCHBGLK_00483(psuG)
CBAR : PATL70BA_2341(yeiN)
ETM : CE91St48_37860(psuG_1) CE91St48_39830(psuG_2)
CST : CLOST_0923 CLOST_1983
PHAR : NCTC13077_00779(psuG)
PIV : NCTC13079_00510(psuG)
TIZ : RBU61_04250 RBU61_16100
AHK : NCTC10172_00507(psuG)
MTER : 4434518_01120(psuG)
CCYS : SAMEA4530656_2568(psuG)
RCR : NCTC10994_01259(psuG)
SFI : SFUL_1526 SFUL_2481 SFUL_5937
SAMB : SAM23877_2049(psuG)
SCZ : ABE83_23575 ABE83_28225
SLE : sle_51690(sle_51690)
SRN : A4G23_01174(psuG_1) A4G23_04735(psuG_2)
SGM : GCM10017557_62730(psuG)
SLX : SLAV_27710(psuG1) SLAV_40130(psuG2)
SGD : ELQ87_09890 ELQ87_29635
SAQU : EJC51_13100 EJC51_24895
SCAV : CVT27_06430 CVT27_10970
STUI : GCM10017668_15870(psuG)
SROI : IAG44_11745 IAG44_30435
STRY : EQG64_06510 EQG64_11500
SGOB : test1122_13715 test1122_24415
SLF : JEQ17_32880 JEQ17_34865
SXT : KPP03845_102179(psuG)
SCOA : QU709_03985 QU709_09970 QU709_33130
AMAU : DSM26151_08400(psuG)
AMAV : GCM10025877_26600(psuG)
NAQU : ENKNEFLB_04412(psuG)
AER : AERYTH_00805 AERYTH_13690
NOA : BKM31_02330 BKM31_11365
MHAI : OHB01_07060 OHB01_36930
KBU : Q4V64_07130 Q4V64_12295
LED : BBK82_01455 BBK82_06855
UME : RM788_06210 RM788_36690 RM788_51355
MICH : FJK98_08325 FJK98_13990
MSAG : GCM10017556_41340(psuG)
ACTR : Asp14428_63610(psuG)
DROS : Drose_08825 Drose_14765 Drose_28385
AHW : NCTC11636_02011(psuG)
BALA : DSM104299_02816(psuG)
» show all
Taxonomy
Reference
Authors
HEINRIKSON RL, GOLDWASSER E.
Title
STUDIES ON THE BIOSYNTHESIS OF 5-RIBOSYLURACIL 5'-MONOPHOSPHATE IN TETRAHYMENA PYRIFORMIS.
Journal
J Biol Chem 239:1177-87 (1964)
Reference
Authors
Matsushita T, Davis FF.
Title
Studies on pseudouridylic acid synthetase from various sources.
Journal
Reference
Authors
Remsen JF, Matsushita T, Chirikjian JG, Davis FF.
Title
Enzymatic synthesis of deoxypseudouridylic acid and a study of certain of its properties.
Journal
Reference
Authors
Suzuki T, Hochster RM.
Title
On the biosynthesis of pseudouridine and of pseudouridylic acid in Agrobacterium tumefaciens.
Journal
Reference
Authors
Preumont A, Snoussi K, Stroobant V, Collet JF, Van Schaftingen E
Title
Molecular identification of pseudouridine-metabolizing enzymes.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.70
ExPASy - ENZYME nomenclature database: 4.2.1.70
LinkDB
All DBs