KEGG   ENZYME: 4.2.1.85
Entry
EC 4.2.1.85                 Enzyme                                 
Name
dimethylmaleate hydratase;
(2R,3S)-2,3-dimethylmalate hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming)
Reaction(IUBMB)
(2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O [RN:R03069]
Reaction(KEGG)
R03069
Substrate
(2R,3S)-2,3-dimethylmalate [CPD:C03652]
Product
dimethylmaleate;
H2O [CPD:C00001]
Comment
Requires Fe2+. Inhibited by oxygen.
History
EC 4.2.1.85 created 1989
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K20452  dimethylmaleate hydratase large subunit
K20453  dimethylmaleate hydratase small subunit
Genes
ELMELI_2736 ELI_2737
EMTCPZ25_006030(leuD) CPZ25_006035(leuC)
ELIMB2M23_20185 B2M23_20190
ETMCE91St48_22370(leuC) CE91St48_22380(leuD)
Reference
1  [PMID:6489933]
  Authors
Kollmann-Koch A, Eggerer H
  Title
Nicotinic acid metabolism. Dimethylmaleate hydratase.
  Journal
Hoppe Seylers Z Physiol Chem 365:847-57 (1984)
DOI:10.1515/bchm2.1984.365.2.847
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.85
IUBMB Enzyme Nomenclature: 4.2.1.85
ExPASy - ENZYME nomenclature database: 4.2.1.85
BRENDA, the Enzyme Database: 4.2.1.85
CAS: 93229-56-2
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