Entry
Name
sirohydrochlorin cobaltochelatase;
CbiK;
CbiX;
CbiXS;
anaerobic cobalt chelatase;
cobaltochelatase [ambiguous];
sirohydrochlorin cobalt-lyase
Class
Lyases;
Other lyases;
Sole sub-subclass for lyases that do not belong in the other subclasses
BRITE hierarchy
Sysname
cobalt-sirohydrochlorin cobalt-lyase (sirohydrochlorin-forming)
Reaction(IUBMB)
cobalt-sirohydrochlorin + 2 H+ = sirohydrochlorin + Co2+ [RN:
R05807 ]
Reaction(KEGG)
Substrate
Product
Comment
This enzyme, which forms part of the anaerobic (early cobalt insertion) cobalamin biosynthesis pathway, is an ATP-independent type II chelatase. Two distinct forms are known - a primordial form named CbiX, which is most common in archaea, and a strictly bacterial form named CbiK. See EC
6.6.1.2 , cobaltochelatase, for the cobaltochelatase that participates in the aerobic cobalamin biosynthesis pathway.
History
EC 4.99.1.3 created 2004, modified 2020
Pathway
Orthology
K02190 sirohydrochlorin cobaltochelatase
K03795 sirohydrochlorin cobaltochelatase
K22011 sirohydrochlorin cobalto/nickelchelatase
Genes
KIE : NCTC12125_04870(cbiK)
BUF : D8682_20865 D8682_24250
BFT : MNO13_05085 MNO13_08230
METY : MRY16398_18730(cbiK)
HAHE : ENC22_09020 ENC22_28400
HAHH : O5O45_03885 O5O45_28170
MMW : Mmwyl1_1378 Mmwyl1_2220
MME : Marme_1279 Marme_2156
MPC : Mar181_1735 Mar181_2564
MPRI : MP3633_1999 MP3633_2673(cbiX)
MARD : IBG28_05690 IBG28_10010
MFOI : JSY38_00630 JSY38_04100
MPRF : J8N69_13420 J8N69_16010
MRHI : KDW99_06000 KDW99_10140
MPON : MACH16_09660 MACH16_16100
OAI : OLEAN_C02900(cbiX) OLEAN_C29540(cbiX)
GSN : YC6258_00112 YC6258_04234
OME : OLMES_2501 OLMES_2754
VFF : VITFI_CDS2750 VITFI_CDS3324
BUE : BRPE67_ACDS05760(cbiX)
PWU : A8O14_01670 A8O14_08605
LMIR : NCTC12852_01757(cbiX)
ACID : CBP33_09350 CBP33_18790
ACIP : CBP36_09030 CBP36_19150
ACIS : CBP35_09905 CBP35_19100
ACIO : EAG14_09395 EAG14_21790
ATEM : PQV96_09310 PQV96_20760
VAP : Vapar_1023 Vapar_2727
OTO : ADJ79_00260 ADJ79_12830
OTD : J1M35_08130 J1M35_11550
LIM : L103DPR2_01734(cbiX)
LIH : L63ED372_01334(sirB)
HPSE : HPF_13625(cbiX1) HPF_17640(cbiX2)
PBH : AAW51_0534(cbiX) AAW51_3109(cbiX)
MPT : Mpe_A1945 Mpe_B0439(cbiX) Mpe_B0474(cbiX)
RDP : RD2015_2258 RD2015_738
ROI : N4261_03960 N4261_15240
PAQA : K9V56_007180 K9V56_012970
SNN : EWH46_08005 EWH46_18660
IDC : LRM40_09790 LRM40_20390
ATER : MW290_12190 MW290_12405
MNR : ACZ75_01840 ACZ75_11395
MFY : HH212_00660 HH212_09235
MALI : EYF70_18665 EYF70_20560
MUM : FCL38_15335 FCL38_28465
MFLA : GO485_03330 GO485_24150
DUG : HH213_09975 HH213_19715
ETB : N7L95_00640 N7L95_04015
UPL : DSM104440_00801(sirB)
OTR : OTERR_09640(cbiX) OTERR_16150(cbiX)
ABRE : pbN1_13950(cbiX1) pbN1_23720(cbiX2)
APET : ToN1_19090 ToN1_20650(cbiX)
DECH : GBK02_13030 GBK02_13955
QAU : KI612_09635 KI612_16160
AZO : azo3377 azo3530(cbiX)
AZA : AZKH_3941(cbiX) AZKH_4156(cbiX)
AZI : AzCIB_3991 AzCIB_4132
AZD : CDA09_19290 CDA09_20100
AZR : CJ010_20615 CJ010_21375
TMZ : Tmz1t_3304 Tmz1t_3738
THU : AC731_011430 AC731_014270
THAU : C4PIVTH_1370 C4PIVTH_2030
TAK : Tharo_2691 Tharo_3209
ACOM : CEW83_11685 CEW83_12090
FMY : HO273_03910 HO273_12680
APP : CAP2UW1_1087 CAP2UW1_2618
RMM : ROSMUCSMR3_03051(cbiX)
LVS : LOKVESSMR4R_00333(cbiX)
SKT : IGS68_05475 IGS68_15045
SMUC : JL100_011095 JL100_027770
SROE : JL101_013205 JL101_014570 JL101_020880
MGY : MGMSRv2__3232 MGMSRv2__3736
MGRY : MSR1_26700 MSR1_29600(cbiX)
MAGN : WV31_00280 WV31_14230
MAGQ : MGMAQ_0066(sirB) MGMAQ_2124
VSU : P3M64_00980 P3M64_07830
SNEA : NBZ79_04830 NBZ79_16470
AFJ : AFERRID_14170 AFERRID_20910
HTL : HPTL_1285(cbiX) HPTL_1950
ANT : Arnit_0389 Arnit_2196
ASUI : ASUIS_1299 ASUIS_1427(cbiK)
AVP : AVENP_1619 AVENP_1742(cbiK)
ALK : ALEK_1838 ALEK_1913(cbiK)
AMYT : AMYT_1480 AMYT_1552(cbiK)
AMAR : AMRN_1390 AMRN_1495(cbiK)
ACAA : ACAN_1443 ACAN_1529(cbiK)
HBV : ABIV_1113 ABIV_1420(cbiK)
PCA : Pcar_0478(cbiK) Pcar_2740(cbiX)
DFI : AXF13_03230 AXF13_13320
DPG : DESPIGER_1805 DESPIGER_2418
DEF : CNY67_07095 CNY67_15240
DTR : RSDT_0425(cbiKp) RSDT_1017(cbiKc)
PSYF : N1030_06285 N1030_16305
DSB : LN040_04405 LN040_15040
DMA : DMR_00730(cbiK) DMR_15530(cbiK)
DCB : C3Y92_00325 C3Y92_13805
DMS : E8L03_00305 E8L03_07730
DSA : Desal_2307 Desal_2802
DHY : DESAM_21640 DESAM_21928(cbiKp)
DAF : Desaf_0152 Desaf_3270
DEJ : AWY79_14895 AWY79_14920
PPRF : DPRO_3922(cbiKc) DPRO_3927
PSEL : GM415_11480 GM415_11505
DDN : DND132_3361 DND132_3366
PSEF : PSDVSF_34450(cbiKp)
PPOR : JCM14722_27960(cbiKp)
PNW : SYK_33610(cbiKc) SYK_33660
PTHE : LF599_05570 LF599_05595
DSX : GD604_03680 GD604_16080
DSD : GD606_08380 GD606_15130 GD606_18435
PBIZ : LWC08_04580 LWC08_06085
DVG : Deval_0595 Deval_1260
CLIH : KPS_000166 KPS_001787
TMUR : JBF11_02860 JBF11_08925
THEW : TDMWS_11660(cbiKp) TDMWS_21280
DLM : DPPLL_27040(cbiKp) DPPLL_37270
DPR : Despr_3029 Despr_3117 Despr_3214
DEO : CAY53_01050 CAY53_08680
DOG : HP555_01235 HP555_08410
DBK : DGMP_11940 DGMP_36310
DAL : Dalk_0440 Dalk_3016 Dalk_4071
DAT : HRM2_07680(cbiK1) HRM2_07700(cbiK2) HRM2_45790(cbiK3)
DTO : TOL2_C34190(cbiK) TOL2_C34310(cbiK2)
DOV : DSCO28_12400(cbiKp) DSCO28_30160
DWD : DSCW_15830 DSCW_33920(cbiKp_1) DSCW_60120(cbiKp_2)
DALK : DSCA_18760 DSCA_32520(cbiKp_1) DSCA_42350(cbiKp_2) DSCA_52380
DML : Dmul_03740(cbiK1) Dmul_21120(cbiK2)
DMM : dnm_048060 dnm_050830
DHR : LGS26_05540 LGS26_06090
BKW : BkAM31D_06045(cbiX_1) BkAM31D_09045(cbiX_2)
ASED : IRT44_00995 IRT44_09810
ALKL : MM271_10475 MM271_10500
SDP : NCTC12225_00462(nirR)
SSTE : SAMEA4384403_0184(nirR)
LMOC : LMOSLCC5850_1191(cbiK)
LMW : LMOSLCC2755_1194(cbiK)
LMX : LMOSLCC2372_1198(cbiK)
LMZ : LMOSLCC2482_1242(cbiK)
LMON : LMOSLCC2376_1153(cbiK)
LMOS : LMOSLCC7179_1169(cbiK)
LMOO : LMOSLCC2378_1207(cbiK)
LMOY : LMOSLCC2479_1199(cbiK)
LMOT : LMOSLCC2540_1181(cbiK)
LMOA : LMOATCC19117_1201(cbiK)
LGZ : NCTC10812_00738(cbiX)
BLR : BRLA_c005370 BRLA_c011890
BFM : BP422_01470 BP422_17050
BAGR : BA6348_09635 BA6348_22640
BRW : GOP56_18620 GOP56_21815
BCHS : JNE38_06615 JNE38_22320
BPAB : PSE45_06210 PSE45_20015
PLV : ERIC2_c08390(cbiX) ERIC2_c32330(cbiK)
PSAB : PSAB_03285 PSAB_08890
PDU : PDUR_03790 PDUR_10110
PBJ : VN24_06730 VN24_23175
PSON : JI735_12525 JI735_18695
PNP : IJ22_31640 IJ22_50900
PDH : B9T62_04030 B9T62_35730
PKB : B4V02_01560 B4V02_21005
PCHI : PC41400_25730 PC41400_27290
PBK : Back11_18320 Back11_39660
PSOP : KP014_06950 KP014_12650
ASOC : CB4_00363(cbiX) CB4_04083
TUM : CBW65_10065 CBW65_11090
LFB : C1X05_07755 C1X05_14105
PABS : JIR001_02970 JIR001_27650
SMEN : SAMEA4412692_0364(cbiK)
LRU : HMPREF0538_20898(cbiK)
PCE : PECL_1389(cbiK) PECL_1391(cbiK)
AUR : HMPREF9243_1731(cbiK)
CAC : CA_C0583 CA_C1373(cbiK)
CAE : SMB_G0597 SMB_G1396(cbiK)
CCB : Clocel_1526 Clocel_2225
CTAE : BGI42_11085 BGI42_11285
CCHV : BTM20_04505 BTM20_06090
CSEP : CP523_01495 CP523_03180
CCOH : SAMEA4530647_0626(cbiK)
CGAS : J1C67_01940 J1C67_02265
CMAH : C1I91_04620 C1I91_22325
CGEL : psyc5s11_38610(cbiK)
CINT : HZF06_22790 HZF06_22970
SARJ : HH195_00195 HH195_04240
SMAN : C12CBH8_09900(cbiKp)
INT : RX717_06430 RX717_13595
DFG : B0537_13920 B0537_13980
DGI : Desgi_0689 Desgi_2021
HCV : FTV88_0720(cbiK) FTV88_2833(cbiX)
EUU : ADJ67_00105 ADJ67_00395
RHO : RHOM_08975 RHOM_08995
BLAB : EYS05_10115 EYS05_16635
BWX : NQ550_04820 NQ550_09180
BMAS : LK422_06375 LK422_13560
BLUI : Blut17040_07130 Blut17040_13630
CSCI : HDCHBGLK_00102(cbiK)
CHYL : CE91St63_25830(cbiK)
ACHT : bsdcttw_22390(cbiK)
SINT : K5I26_05750 K5I26_10680
VPY : HZI73_05500 HZI73_24305
PDC : CDIF630_03730(cbiKP)
PDF : CD630DERM_34220(cbiK)
PHX : KGNDJEFE_00488(cbiK)
PIV : NCTC13079_00684(cbiK)
VPR : Vpar_1131 Vpar_1132 Vpar_1135
VAT : B7L28_05590 B7L28_05595 B7L28_05625
VRM : 44547418_01200(cbiKp) 44547418_01201(cbiK_1) 44547418_01205(cbiK_2)
VDN : NCTC11831_00758(cbiK_1) NCTC11831_00759(cbiK_2) NCTC11831_00760(cbiKp)
VNK : VEIT17_06990(cbiK_1) VEIT17_07000(cbiK_2) VEIT17_07010(cbiK_3)
VRG : OKW85_03755 OKW85_03780 OKW85_03785
DHO : Dia5BBH33_07730(cbiK)
SSG : Selsp_1415 Selsp_1606 Selsp_1668
SRI : SELR_08950(cbiK) SELR_17050(cbiK)
SGBI : P3F81_08730 P3F81_08735
PUF : UFO1_0852 UFO1_1006 UFO1_3780
MANA : MAMMFC1_00107(cbiK_1) MAMMFC1_04243(cbiKp)
STED : SPTER_03270(cbiK_1) SPTER_03560(cbiK_2) SPTER_41590(cbiK_3)
PFAC : PFJ30894_00513(cbiK)
SHI : Shel_24480 Shel_24820
ERZ : ER308_05370 ER308_09765
RANT : RHODO2019_04940 RHODO2019_17845
SAMB : SAM23877_1931(cbiX)
SLE : sle_52750(sle_52750)
PAK : HMPREF0675_3456(cbiX)
CGRN : 4412665_00757(cbiX)
PAUS : NCTC13651_00951(cbiX)
MHAI : OHB01_00345 OHB01_28620
RRD : RradSPS_0824 RradSPS_1126
SYY : SYNGTS_2831(sll0037)
SYT : SYNGTI_2830(sll0037)
SYS : SYNPCCN_2829(sll0037)
SYQ : SYNPCCP_2829(sll0037)
SYR : SynRCC307_0990(cbiX)
SYX : SynWH7803_1422(cbiX)
CYA : CYA_0930 CYA_2373(cbiX)
CYB : CYB_1039 CYB_2347(cbiX)
SYNW : SynWH8103_00951(cbiX)
DSL : Dacsa_2931 Dacsa_3396
CYN : Cyan7425_1197 Cyan7425_3558
ACAM : HRE53_07835 HRE53_18165
TSZ : OOK60_06615 OOK60_07440
LET : O77CONTIG1_03670(cbiX_1) O77CONTIG1_04169(cbiX_2)
HHG : XM38_006540(cbiX_1) XM38_037950(cbiX_2)
PSEU : Pse7367_0288 Pse7367_0371
THEU : HPC62_13700 HPC62_18845
TOG : HNI00_15175 HNI00_16990
TSIN : OXH18_16925 OXH18_20380
GLP : Glo7428_0212 Glo7428_4611
CHON : NIES4102_06100 NIES4102_21920
GDU : P0S91_04510 P0S91_10505
GEN : GM3709_1035 GM3709_2674
CSN : Cyast_0139 Cyast_1963
MVZ : myaer102_40250(cbiX)
HAO : PCC7418_2366 PCC7418_3611
ENN : FRE64_00680 FRE64_06400
CWA : CwatDRAFT_0412 CwatDRAFT_5932
CYP : PCC8801_2287 PCC8801_3840
CYH : Cyan8802_2338 Cyan8802_3890
CYC : PCC7424_3112 PCC7424_4496
CYJ : Cyan7822_0213 Cyan7822_3795
PPSU : NO713_01259(cbiX) NO713_02089(cbiX)
OXY : HCG48_08275 HCG48_15430
LFS : HFV01_02005 HFV01_02010
MIC : Mic7113_0069 Mic7113_2403
GEI : GEI7407_1650 GEI7407_3514
RIV : Riv7116_2759 Riv7116_3106
CTHE : Chro_3008 Chro_5224
PLP : Ple7327_1702 Ple7327_2570
SCS : Sta7437_1623 Sta7437_3539
STAN : STA3757_04720 STA3757_09840
CER : RGRSB_0927 RGRSB_1664
CEEC : P3F56_04830 P3F56_06825
RRS : RoseRS_0565 RoseRS_4477
DWU : DVJ83_08855 DVJ83_18305
ROO : G5S37_15625 G5S37_21135
FPOL : ERS445057_00925(cbiK)
IPO : Ilyop_2621 Ilyop_2622
CSOM : MKD34_00075 MKD34_13800
LHF : JCM16775_2391 JCM16775_2428
BHL : Bache_2221 Bache_2225
BCEL : BcellWH2_00346(cbiKp) BcellWH2_00350(cbiK_1) BcellWH2_00357(cbiK_2)
BUN : Bun01g_25530 Bun01g_25600
BSTE : K6V31_04215 K6V31_04225
BHUM : JXR92_012185 JXR92_012220
PAH : Poras_0007 Poras_0017
PCRE : NCTC12858_00966(cbiK)
PCAG : NCTC12856_01948(cbiK)
PEND : LA319_00320 LA319_07395
PSOE : CE91St14_01600 CE91St14_05240
PDI : BDI_1070 BDI_3409 BDI_3410
PARC : CI960_00135 CI960_00140 CI960_09070
PJO : LK449_08300 LK449_08305
TOH : BCB71_03530 BCB71_07545
PROC : Ptc2401_01277(cbiKp)
PROW : OO006_07330 OO006_07335
PROI : OO005_06795 OO005_06800
NDE : NIDE0206 NIDE2091(cbiX)
NMV : NITMOv2_0146 NITMOv2_1590(cbiX)
METB : AW729_07475 AW729_09690
MEIS : PXD04_03550(cfbA) PXD04_11515
MFC : BRM9_0750(cbiX) BRM9_2283
MFI : DSM1535_0709 DSM1535_1217
METT : CIT01_05355 CIT01_09230
METO : CIT02_07815 CIT02_10385
MFEG : GCM10025860_05960 GCM10025860_15770
MBA : Mbar_A0344 Mbar_A2400
MBW : MSBRW_0653 MSBRW_2346
METM : MSMTP_0889 MSMTP_0890
MSJ : MSSAC_1168 MSSAC_1225
MSZ : MSSIH_1080 MSSIH_2811
MSW : MSSIT_1127 MSSIT_2845
MCJ : MCON_0747(cbiK) MCON_1928(cbiX) MCON_2896(cbiK)
MANQ : L1994_02775 L1994_05920(cfbA)
MPD : MCP_0361(cbiX-1) MCP_1070
RCI : RCIX2006(cbiX-1) RRC53
HSL : OE_2585R(cbiX2) OE_3221F(cbiX1)
HANR : LJ422_04480 LJ422_06345
HHB : Hhub_2298(cbiX2) Hhub_2900(cbiX1)
HAGS : JT689_05735 JT689_07685
HABO : JRZ79_04200 JRZ79_06100
HNO : LT974_07200 LT974_11280
HDO : MUK72_12830 MUK72_18245
SAIM : K0C01_05425 K0C01_09820
HARA : AArcS_0654 AArcS_1195
HMA : rrnAC1289 rrnAC3011(cbiK)
HHI : HAH_0267(cbiK) HAH_1880(cbiX2)
HHN : HISP_01420 HISP_09590
HTA : BVU17_01320 BVU17_09095
HALJ : G9465_01485 G9465_14605
HSIN : KDQ40_04060 KDQ40_12315
NPH : NP_1108A(cbiX1) NP_1588A(cbiX2)
NMO : Nmlp_3060(cbiX2) Nmlp_3779(cbiX1)
NHO : HWV23_04325 HWV23_08990
NSAL : HWV07_03400 HWV07_12710
HALZ : E5139_12450 E5139_14035
HALL : LC1Hm_1191 LC1Hm_1648
HAZP : GBQ70_12460 GBQ70_14050
HALI : BV210_02880 BV210_15250
HAAD : MW046_10980 MW046_12755
HWA : HQ_1656A(cbiX2) HQ_3032A(cbiX1)
HWC : Hqrw_1771(cbiX2) Hqrw_3549(cbiX1)
HVO : HVO_1128(cbiX2) HVO_B0054(cbiX1)
HME : HFX_1136(cbiX) HFX_5058(cbiK)
HGI : ABY42_05500 ABY42_15730
HALE : G3A49_06915 G3A49_08860
HLS : KU306_03945 KU306_10330
HLN : SVXHx_1082(cbix) SVXHx_3418(cbix)
HBO : Hbor_03430 Hbor_21160
HRA : EI982_05795 EI982_12445
HLM : DV707_02885 DV707_08505
HAE : halTADL_0869 halTADL_3159
HMP : K6T50_05935 K6T50_18765
HRE : K6T36_05675 K6T36_17910
HACB : Hbl1158_00250 Hbl1158_12250
HSAL : JMJ58_03490 JMJ58_03985
HAKZ : J0X25_12010 J0X25_13265
HXA : Halxa_2932 Halxa_3702
NPE : Natpe_2695 Natpe_2749
NVR : FEJ81_12450 FEJ81_12680
NPL : FGF80_12095 FGF80_12440
NAY : HYG81_15640 HYG81_16045
HALY : HYG82_00250 HYG82_01075
HJT : DVR14_03450 DVR14_03685
HLO : J0X27_16070 J0X27_16700
NOU : Natoc_1040 Natoc_4255
HLR : HALLA_09870 HALLA_10065
HLC : CHINAEXTREME18625 CHINAEXTREME19855
NAJ : B1756_11735 B1756_16140
NAG : AArcMg_1619 AArcMg_1718
NAN : AArc1_1914 AArc1_2022
NBG : DV706_01745 DV706_02640 DV706_15525
NAS : GCU68_10905 GCU68_11995
HDA : BB347_03105 BB347_03465
MEAR : Mpt1_c07010(cbiX1) Mpt1_c08040(cbiX2)
MEUZ : KRP56_02450 KRP56_04280
MARC : AR505_0597 AR505_1503
» show all
Taxonomy
Reference
Authors
Raux E, Thermes C, Heathcote P, Rambach A, Warren MJ
Title
A role for Salmonella typhimurium cbiK in cobalamin (vitamin B12) and siroheme biosynthesis.
Journal
Reference
Authors
Schubert HL, Raux E, Wilson KS, Warren MJ.
Title
Common chelatase design in the branched tetrapyrrole pathways of heme and anaerobic cobalamin synthesis.
Journal
Sequence
Reference
Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
Title
The biosynthesis of adenosylcobalamin (vitamin B12).
Journal
Reference
Authors
Brindley AA, Raux E, Leech HK, Schubert HL, Warren MJ.
Title
A story of chelatase evolution: identification and characterization of a small 13-15-kDa "ancestral" cobaltochelatase (CbiXS) in the archaea.
Journal
Sequence
Reference
Authors
Frank S, Brindley AA, Deery E, Heathcote P, Lawrence AD, Leech HK, Pickersgill RW, Warren MJ
Title
Anaerobic synthesis of vitamin B12: characterization of the early steps in the pathway.
Journal
Reference
Authors
Lobo SA, Brindley AA, Romao CV, Leech HK, Warren MJ, Saraiva LM
Title
Two distinct roles for two functional cobaltochelatases (CbiK) in Desulfovibrio vulgaris hildenborough.
Journal
Reference
Authors
Lobo SA, Videira MA, Pacheco I, Wass MN, Warren MJ, Teixeira M, Matias PM, Romao CV, Saraiva LM
Title
Desulfovibrio vulgaris CbiK(P) cobaltochelatase: evolution of a haem binding protein orchestrated by the incorporation of two histidine residues.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.99.1.3
ExPASy - ENZYME nomenclature database: 4.99.1.3
LinkDB
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