| Entry |
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| Name |
4-hydroxyproline epimerase;
hydroxyproline epimerase;
hydroxyproline 2-epimerase;
L-hydroxyproline epimerase
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| Class |
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
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| Sysname |
4-hydroxyproline 2-epimerase
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| Reaction(IUBMB) |
trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline [RN: R03296]
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| Reaction(KEGG) |
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| Substrate |
trans-4-hydroxy-L-proline [CPD: C01157]
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| Product |
cis-4-hydroxy-D-proline [CPD: C03440]
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| Comment |
Also interconverts trans-4-hydroxy-D-proline and cis-4-hydroxy-L-proline.
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| History |
EC 5.1.1.8 created 1965, modified 1983
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| Pathway |
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| Orthology |
| K12658 | 4-hydroxyproline epimerase |
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| Genes |
| XPH: | XppCFBP6546_19660(XppCFBP6546P_19660) |
| RGL: | CS053_00950 CS053_07865 |
| PNC: | NCGM2_2151 NCGM2_3706 |
| PAEB: | NCGM1900_1307 NCGM1900_3822 |
| PCQ: | PcP3B5_24830 PcP3B5_28750 PcP3B5_34570 |
| PMED: | E3Z27_11940 E3Z27_15330 |
| PFW: | PF1751_v1c27910(prpA) |
| PBA: | PSEBR_a3196 PSEBR_a3615 |
| PSES: | PSCI_2441(prdF) PSCI_5066 |
| PEZ: | HWQ56_12105 HWQ56_17335 |
| PVW: | HU752_014635 HU752_021515 |
| PFAK: | KSS94_16245 KSS94_20280 |
| PIZ: | LAB08_R19210 LAB08_R22610 |
| BCEN: | DM39_3735 DM39_4868(prpA) |
| BAC: | BamMC406_3228 BamMC406_4031 |
| BMJ: | BMULJ_03255(prdF) BMULJ_04062(prdF) |
| BMK: | DM80_3612 DM80_4477(prpA) |
| BYI: | BYI23_B007710 BYI23_C005580 BYI23_D012930 |
| BUE: | BRPE67_BCDS11660 BRPE67_CCDS05880 BRPE67_DCDS01610 |
| BXB: | DR64_6195 DR64_6722(prpA) |
| PARB: | CJU94_22135 CJU94_24675 |
| PCJ: | CUJ87_17800 CUJ87_32180 |
| PCAF: | DSC91_000916 DSC91_002492 |
| PDIO: | PDMSB3_1683.1 PDMSB3_2311.1 |
| PSAA: | QEN71_20260 QEN71_34275 |
| PTX: | ABW99_01800 ABW99_02275 |
| BUO: | BRPE64_BCDS05530 BRPE64_DCDS01060 |
| CABK: | NK8_34220 NK8_52040 NK8_80940 |
| TVL: | FAZ95_14675 FAZ95_32800 FAZ95_35280 |
| ASW: | CVS48_09900 CVS48_27745 |
| KIA: | G8A07_04590 G8A07_14900 |
| TCT: | PX653_09760 PX653_15190 |
| MAMO: | A6B35_02220 A6B35_24420 |
| MESR: | FGU64_13235 FGU64_15400 |
| MOH: | IHQ72_05710 IHQ72_13285 |
| BSG: | IY72_08545 IY72_14185 |
| STAR: | G3545_19665 G3545_23210 |
| APRA: | G3A50_09700 G3A50_11700 |
| RHP: | LPB142_00850 LPB142_07535 |
| PMEH: | JWJ88_18840 JWJ88_20635 |
| NOV: | TQ38_021135 TQ38_024025 |
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| Reference |
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| Authors |
ADAMS E, NORTON IL. |
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| Title |
PURIFICATION AND PROPERTIES OF INDUCIBLE HYDROXYPROLINE 2-EPIMERASE FROM PSEUDOMONAS. |
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| Journal |
J Biol Chem 239:1525-35 (1964) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.1.1.8 |
| ExPASy - ENZYME nomenclature database: | 5.1.1.8 |
| BRENDA, the Enzyme Database: | 5.1.1.8 |
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| LinkDB |
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