Entry
Name
3-hydroxypropionyl-CoA synthase;
3-hydroxypropionyl-CoA synthetase (AMP-forming);
3-hydroxypropionate---CoA ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
hydroxypropanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate [RN:
R09286 ]
Reaction(KEGG)
Substrate
Product
Comment
Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1,2].The enzymes from Metallosphaera sedula and Sulfolobus tokodaii can also use propionate, acrylate, acetate, and butanoate as substrates [2], and are thus different from EC
6.2.1.17 (propionate---CoA ligase), which does not accept acetate or butanoate.
History
EC 6.2.1.36 created 2009
Pathway
ec00720 Carbon fixation pathways in prokaryotes
ec01120 Microbial metabolism in diverse environments
Orthology
K14469 acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
K15018 3-hydroxypropionyl-coenzyme A synthetase
Genes
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Taxonomy
Reference
Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
Journal
Reference
Authors
Alber BE, Kung JW, Fuchs G
Title
3-Hydroxypropionyl-coenzyme A synthetase from Metallosphaera sedula, an enzyme involved in autotrophic CO2 fixation.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.36
ExPASy - ENZYME nomenclature database: 6.2.1.36
LinkDB
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