KEGG ENZYME: 6.3.2.7

ENZYME: 6.3.2.7

Entry

EC 6.3.2.7                  Enzyme

Name

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase;
MurE synthetase;
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase;
uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase;
UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase;
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)

Class

Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)

Sysname

UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)

Reaction(IUBMB)

ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine [RN:R02786]

Reaction(KEGG)

R02786

Substrate

ATP [CPD:C00002];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate [CPD:C00692];
L-lysine [CPD:C00047]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine [CPD:C05892]

Comment

Involved in the synthesis of a cell-wall peptide in bacteria. This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase) adds 2,6-diaminopimelate instead.

History

EC 6.3.2.7 created 1961, modified 2002

Pathway

ec00550

Peptidoglycan biosynthesis

ec01100

Metabolic pathways

Orthology

K05362

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

Genes

SDO:	SD1155_07410

BACO:

OXB_1857

BHAI:

KJK41_07960

OIH:

OB1998

LSP:

Bsph_1281

LFU:	HR49_19765

LYS:	LBYS11_03725

LYB:	C3943_04735

LYZ:	DCE79_03385

LYG:	C1N55_05265

LPAK:

GDS87_04015

LAGR:

FJQ98_04825

LMAC:

I6G82_14570

LYC:	FH508_0003860

LCAP:

ICJ70_20525

LYP:	MTP04_10770(murE_1)

LIU:	OU989_03485

LLB:	R6U77_01025

VIR:	X953_06650

VIK:	KFZ58_10795

BVQ:	FHE72_08510

RMF:	D5E69_08915

RAZ:	U9J35_08545

SAU:	SA0876(murE)

SAV:	SAV1018(murE)

SAW:	SAHV_1012(murE)

SAH:	SaurJH1_1035

SAJ:	SaurJH9_1016

SAM:	MW0899(murE)

SAS:

SAS0887

SAR:	SAR0988(murE)

SAC:	SACOL1023(murE)

SAX:	USA300HOU_0976(murE1)

SAA:	SAUSA300_0919(murE)

SAO:	SAOUHSC_00954

SAE:	NWMN_0888(murE)

SAD:

SAAV_0980

SUU:	M013TW_0943

SUV:	SAVC_04255

SUE:

SAOV_0963

SUJ:	SAA6159_00874

SUK:	SAA6008_00973(murE)

SUC:	ECTR2_873(murE)

SUT:	SAT0131_01053

SUQ:	HMPREF0772_12216(murE)

SUZ:	MS7_0974(murE)

SUD:	ST398NM01_1014

SUX:	SAEMRSA15_08480(murE)

SUW:	SATW20_10150(murE)

SUG:

SAPIG1014

SUF:	SARLGA251_09330(murE)

SAUA:

SAAG_02127

SAUE:

RSAU_000903(murE)

SAUN:

SAKOR_00936

SAUS:

SA40_0888(murE)

SAUU:

SA957_0903(murE)

SAUG:

SA268_0905(murE)

SAUZ:

SAZ172_0959(murE)

SAUT:

SAI1T1_2007200

SAUJ:

SAI2T2_1007220

SAUK:

SAI3T3_1007210

SAUQ:

SAI4T8_1007200

SAUV:

SAI7S6_1007210(murE)

SAUW:

SAI5S5_1007170(murE)

SAUX:

SAI6T6_1007180(murE)

SAUY:

SAI8T7_1007210(murE)

SAUF:

X998_1016

SAB:	SAB0884(murE)

SUY:	SA2981_0972(murE)

SAUB:

C248_1042(murE)

SAUM:

BN843_9230

SAUC:

CA347_935(murE)

SAUR:

SABB_00986(murE)

SAUI:

AZ30_04840

SAUD:

CH52_00795

SAMS:

NI36_04845

SUH:	SAMSHR1132_08650

SER:	SERP0607(murE)

SEP:

SE_0718

SEPP:

SEB_00697

SEPS:

DP17_2003(murE)

SHA:	SH1941(murE)

SHH:	ShL2_01803(murE)

SSP:

SSP1767

SCA:	SCA_0621(murE)

SLG:	SLGD_01850

SLN:	SLUG_18440(murE)

SSD:	SPSINT_0714

SDT:	SPSE_1819(murE)

SDP:	NCTC12225_02039(murE)

SWA:	A284_08685

SPAS:

STP1_2087

SXY:	BE24_02440

SXL:	SXYLSMQ121_1766

SXO:	SXYL_01914(murE)

SHU:	SHYC_09250(murE-2)

SCAP:

AYP1020_0275(murE)

SSCH:

LH95_08705

SSCZ:

RN70_09185

SAGQ:

EP23_00740

SEQO:

SE1039_07730

SSIF:

AL483_06880

SCV:	A4G25_04830

SPET:

CEP67_11885

SLZ:	B5P37_09085

SCOH:

BZ166_00755

SNL:	BJD96_09795

SKL:	C7J89_10925

SFQ:	C7J90_06800

SHOM:

EGX58_01800(murE)

SMUS:

C7J88_10310

SCAR:

DWB96_09560(murE)

SCHR:

DWB92_09015(murE)

SARL:

SAP2_18050(murE)

SPIC:

SAMEA4384060_1942(murE)

SSH:	NCTC13712_00961(murE)

SSIM:

SAMEA4384339_0867(murE)

SDB:	CNQ82_04845(murE)

SLLO:

ISP08_08885

SAUL:

I6G39_08185

SSAC:

I6I31_07320

SRAI:

LN051_08190

SPSD:

JMB28_09590

STAS:

HYI43_09080

SURY:

MUA21_03625

SEDA:

MNY58_09470

SCAQ:

QMO72_09505

SDEV:

Q2T90_10315

SROT:

ML435_04595

STAP:

AOB58_979

SSCU:

CEP64_08610

SFF:	FOB90_10775

SSTE:

SAMEA4384403_1838(murE)

MLEN:

H3V22_13400

MVT:	I6J10_02135

MACR:

BHM04_06280

MARY:

LAU42_03710

MBRU:

MGG13_03915

MEPI:

KFV12_04705

MEQU:

KFV11_03680

MBOC:

QSV55_03905

MCL:	MCCL_0631(murE)

MCAK:

MCCS_08580(murE)

MBOE:

HT586_04535

SHV:	AAT16_03595

JEA:	JEM45_04525

NAMP:

KPF49_02030

NMY:	CJ229_008575

SBAC:

BVH56_06325

GOT:	AXE85_03625

GMO:	NCTC11323_01073(murE)

GEQ:	CG018_05765

GSA:	FOC50_07515

GHA:	NCTC10459_00697(murE)

SIV:

SSIL_3199

SSIL:

SOLI23_02570

SOB:	CSE16_03405

PLN:	Plano_2069

PKU:	AUO94_05340

PRT:	AUC31_16570

PLL:	I858_012485

PANA:

BBH88_08720

PDG:	BCM40_04900

PHC:	BBI08_07600

PMAR:

B0X71_12800

PPLA:

BBI15_06065

PFAE:

AJGP001_12205

PLX:	CW734_12065

PMAT:

BBI11_11520

PDEC:

H1Q58_10780

JEO:

JMA_14530

KUR:	ASO14_2324(murE)

KZO:	NCTC404_00255(murE)

SPSY:

AZE41_16520

SPOR:

SporoP33_13420

SPOP:

SporoP37_13755

SURE:

SporoP32a_14055

SPOS:

DV702_01735

SPAE:

E2C16_09495

SPOO:

J3U78_06745

SURL:

BI350_13355

RST:	ATY39_01725

PAEK:

D3873_03840

PANC:

E2636_11030

PLAY:

DNR44_009310

VIJ:	JNUCC6_18910

UTH:	DKZ56_06045

LLK:	LLKF_1979(murE)

LLT:	CVCAS_1739(murE)

LLS:	lilo_1789(murE)

LLD:	P620_10210

LLX:	NCDO2118_1912(murE)

LLJ:	LG36_1762(murE)

LLC:

LACR_1987

LLR:

llh_3110

LLN:	LLNZ_10265(murE)

LLI:	uc509_1759(murE)

LLW:	kw2_1860(murE)

LGR:

LCGT_0383

LGV:

LCGL_0383

LPK:	LACPI_2096(murE)

LRN:	CMV25_06495

LACT:

D7I46_06865(murE)

LTI:	JW886_08480

LPAA:

BHS01_09930

LPET:

lgb_00390(murE)

LFO:	LMK00_01935

SPY:	SPy_0388(murE)

SPZ:	M5005_Spy0325(murE)

SPYM:

M1GAS476_0392(murE)

SPYA:

A20_0373c(murE)

SPM:	spyM18_0440(murE)

SPG:	SpyM3_0284(murE)

SPS:

SPs1575

SPH:	MGAS10270_Spy0320(murE)

SPI:	MGAS10750_Spy0321(murE)

SPJ:	MGAS2096_Spy0343(murE)

SPK:	MGAS9429_Spy0324(murE)

SPF:	SpyM51533(murE)

SPA:	M6_Spy0351

SPB:	M28_Spy0314(murE)

STG:	MGAS15252_0351(murE.1)

STX:	MGAS1882_0351(murE.1)

SOZ:	Spy49_0319c(murE)

STZ:	SPYALAB49_000354(murE)

SPYH:

L897_01765

SPN:	SP_1530(murE)

SPD:	SPD_1359(murE)

SPR:	spr1384(murE)

SPW:	SPCG_1517(murE)

SJJ:

SPJ_1434

SNV:	SPNINV200_13670(murE)

SPX:	SPG_1456(murE)

SNT:

SPT_1468

SND:

MYY_1460

SPNN:

T308_06950

SNE:	SPN23F14930(murE)

SPV:

SPH_1643

SNC:	HMPREF0837_11764(murE)

SNM:	SP70585_1569

SPP:

SPP_1552

SNI:	INV104_13020(murE)

SPNG:

HMPREF1038_01514

SNB:	SP670_1613

SNP:

SPAP_1552

SNX:	SPNOXC13410(murE)

SNU:	SPNA45_00691(murE)

SPNE:

SPN034156_04290(murE)

SPNU:

SPN034183_13400(murE)

SPNM:

SPN994038_13290(murE)

SPNO:

SPN994039_13300(murE)

SAG:	SAG1391(murE)

SAN:

gbs1461

SAK:	SAK_1424(murE)

SGC:	A964_1305(murE)

SAGS:

SaSA20_1131(murE)

SAGL:

GBS222_1144(murE)

SAGM:

BSA_14720

SAGI:

MSA_15140

SAGR:

SAIL_14460

SAGP:

V193_06190

SAGC:

DN94_06190

SAGT:

GBSCOH1_1262

SAGE:

EN72_07725

SAGG:

EN73_06915

SAGN:

W903_1407(murE)

SAGJ:

ID870_02680

SMU:	SMU_1677(murE)

SMC:	SmuNN2025_0440(murE)

SMUT:

SMUGS5_07580

SMJ:	SMULJ23_0456(murE)

SMUA:

SMUFR_1459

STC:	str0349(murE)

STL:	stu0349(murE)

STE:

STER_0387

STN:

STND_0341

STU:	STH8232_0447(mure)

STW:

Y1U_C0334

STHE:

T303_02880

STHS:

AVT04_03150

SSA:	SSA_1739(murE)

SSB:	SSUBM407_1216(murE)

SSU:	SSU05_0651

SSV:	SSU98_0652

SSI:	SSU0608(murE)

SSS:	SSUSC84_0581(murE)

SSF:	SSUA7_0606(murE)

SSW:	SSGZ1_0642

SUP:

YYK_02890

SSUS:

NJAUSS_0712

SST:	SSUST3_0812(murE)

SSUY:

YB51_4025

SSK:	SSUD12_1217(murE)

SUI:	SSUJS14_0741(murE)

SUO:	SSU12_0607(murE)

SRP:	SSUST1_1159(murE)

SSUT:

TL13_1126(murE)

SSUI:

T15_1332(murE)

SGO:	SGO_1638(murE)

SEZ:	Sez_1617(murE)

SEQ:

SZO_03550

SEZO:

SeseC_02166(murE)

SEQU:

Q426_00770

SEU:

SEQ_1835

SUB:	SUB0425(murE)

SDS:	SDEG_0435(murE)

SDG:	SDE12394_02090

SDA:	GGS_0424(murE)

SDC:	SDSE_0454(murE)

SDQ:	SDSE167_0474(murE)

SGA:	GALLO_1770(murE)

SGG:	SGGBAA2069_c17290(murE)

SGT:	SGGB_1757(murE)

SMB:	smi_1512(murE)

SOR:	SOR_0659(murE)

STK:

STP_1332

STB:	SGPB_1578(murE.2)

SCP:	HMPREF0833_10974(murE)

SCF:	Spaf_1551(murE2)

SSR:	SALIVB_0346(murE)

STF:	Ssal_01844(murE)

STJ:	SALIVA_0324(murE)

STRS:

SSAL8618_01905

SSAH:

HSISS4_00276(murE)

STD:	SPPN_07500

SMN:	SMA_1676(murE)

SIF:	Sinf_1499(murE)

SIE:	SCIM_0429(murE)

SIB:	SIR_1231(murE)

SIU:	SII_1255(murE)

SANG:

SAIN_0463(murE)

SANC:

SANR_0481(murE)

SANS:

DK43_07865

SCG:	SCI_0511(murE)

SCON:

SCRE_0491(murE)

SCOS:

SCR2_0491(murE)

SOI:	I872_05895

SIK:

K710_1552

SIQ:	DQ08_07240

SIO:	DW64_07225

SIZ:	SI82_07345

SLU:

KE3_1632

SIG:	N596_04825

SIP:	N597_06680

STV:	V470_02995

SPAT:

A0O21_01685

STRA:

ATM98_04500

STRN:

SNAG_0628(murE)

SSOB:

DK181_08630(murE)

SRQ:	SR187_6770

SEQI:

A6J79_04620(murE)

SKI:	D7D50_05820(murE)

SPEI:

EHW89_02275(murE)

SRAT:

FY406_06125

SGW:	D7D53_05730(murE)

SPLR:

C0J00_02250

STRG:

SRT_04560(murE)

SVB:	NCTC12167_00375(murE_1)

SMEN:

SAMEA4412692_1073(murE)

SFER:

NCTC12278_01481(murE)

SCAI:

NCTC12191_00119(murE)

SPSU:

NCTC13786_01732(murE)

SCHJ:

DDV21_008855(murE)

SPOC:

NCTC10925_01423(murE)

SPAB:

KQ224_10235

SLAT:

J4854_08020

SAUP:

NCTC3168_01256(murE)

SURN:

NCTC13766_01698(murE)

SACO:

SAME_00581(murE_1)

SVF:	NCTC3166_01492(murE)

SOS:	INT76_03075

STOY:

STYK_14530(murE)

SRUM:

GPZ88_02250

SACY:

O6R09_07245

SMIE:

NCTC11169_00434(murE)

SRUN:

LPB404_08075

FPEN:

KIW23_09135

LMU:	LBLM1_00055

LVA:	LV515_09230(murE)

LPON:

LP475_08555(murE)

LGAS:

LG045_09270(murE) LG045_09275(murE)

LPOR:

PRK60_09190(murE)

LNN:	F0161_11015(murE)

EFA:	EF0668(murE)

EFL:	EF62_1038(murE)

EFI:	OG1RF_10399(murE)

EFD:	EFD32_0482

EFS:	EFS1_0515(murE)

EFN:	DENG_00697(murE)

EFQ:	DR75_2617(murE)

EFC:	EFAU004_02569

EFAU:

EFAU085_02652

EFU:	HMPREF0351_12511(murE2)

EFM:

M7W_2527

EFT:	M395_11930

EHR:

EHR_05945

ECAS:

ECBG_02266

EMU:

EMQU_2676

EDU:

LIU_02615

EGA:	AL523_03305

ESS:	ATZ33_15015

ETH:	CK496_11385

EGV:	EGCR1_10725(murE)

EAV:	EH197_22045(murE)

ESG:	EsVE80_02820(murE2)

ELAC:

I4Q40_11975

ECEC:

NCTC12421_02150(murE)

ERAF:

J9537_12845

EIE:	ENLAB_14990(murE_2)

EDS:	PML78_06265

EMS:	P3T75_11975

MPS:

MPTP_1715

MPX:

MPD5_0348

THL:	TEH_01090(murE)

TEY:	GLW17_06280(murE)

TOO:	C7K38_03850

TKR:	C7K43_09960

VTE:	BHY08_05245

VPI:	BW732_00325

VAC:	E4Z98_04960(murE)

VAO:	FA707_05565(murE)

VAH:	G7081_05755

VCP:	H9L18_08285

VHY:	G7082_12370

VFV:	K5K99_09460

VLU:	M2919_01605(murE)

VLC:	G314FT_15050(murE)

VIE:	OL234_05105

AUI:	APT62_06795

ACG:	AWM71_05850

AVS:	AWM76_03400

AUH:	AWM75_06455

ALOY:

CJ190_002905

AMIT:

DBT49_0003325

ATJ:	DBT50_009000(murE)

CML:	BN424_209(murE)

CARN:

FPV25_04635(murE)

DPM:	FNV33_08880(murE)

DINC:

QNK01_07860

FSA:	C5Q98_01550

LASA:

L9O85_14680(argB)

PALM:

RBG61_09480

IBU:	IB211_00151

COO:

CCU_09610

CCOM:

I6K69_13995

CEV:	LK421_04065 LK421_09800

QDO:	H9Q78_12455

WHJ:	H9Q79_08600(murE)

SMOE:

RGT18_02270

OLO:	ADJ70_02405

TIO:	INP52_09145

CGO:	Corgl_0162

COLL:

KPC83_01475

BDE:	BDP_1522(mur)

BDN:

BBDE_1446

BSUE:

BS3272_03770

» show all

Reference

Authors

Ito, E. and Strominger, J.L.

Title

Enzymatic synthesis of the peptide in bacterial uridine nucleotides. I. Enzymatic addition of L-alanine, D-glutamic acid, and L-lysine.

Journal

J Biol Chem 237:2689-2695 (1962)

Reference

2 [PMID:11699883]

Authors

van Heijenoort J

Title

Recent advances in the formation of the bacterial peptidoglycan monomer unit.

Journal

Nat Prod Rep 18:503-19 (2001)
DOI:10.1039/a804532a

Other DBs

ExplorEnz - The Enzyme Database:

6.3.2.7

IUBMB Enzyme Nomenclature:

6.3.2.7

ExPASy - ENZYME nomenclature database:

6.3.2.7

BRENDA, the Enzyme Database:

6.3.2.7

CAS:

9023-51-2

LinkDB

DBGET integrated database retrieval system