KEGG   ENZYME: 6.4.1.5
Entry
EC 6.4.1.5                  Enzyme                                 
Name
geranoyl-CoA carboxylase;
geranoyl coenzyme A carboxylase;
geranyl-CoA carboxylase
Class
Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
Sysname
geranoyl-CoA:carbon-dioxide ligase (ADP-forming)
Reaction(IUBMB)
ATP + geranoyl-CoA + HCO3- = ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA [RN:R03494]
Reaction(KEGG)
R03494
Substrate
ATP [CPD:C00002];
geranoyl-CoA [CPD:C01920];
HCO3- [CPD:C00288]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA [CPD:C01291]
Comment
A biotinyl-protein. Also carboxylates dimethylpropenoyl-CoA and farnesoyl-CoA.
History
EC 6.4.1.5 created 1972
Pathway
ec00907  Pinene, camphor and geraniol degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K13777  geranyl-CoA carboxylase alpha subunit
K13778  geranyl-CoA carboxylase beta subunit
Genes
RGL: CS053_05360 CS053_05370
DJI: CH75_09960 CH75_09970
TAMN: N4264_17005 N4264_17015
PAE: PA2888(atuC) PA2891(atuF)
PAEV: N297_2991 N297_2994
PAEI: N296_2991 N296_2994
PAU: PA14_26670 PA14_26720(mccB)
PAP: PSPA7_2263 PSPA7_2266
PAG: PLES_21731(atuF) PLES_21761(atuC)
PAF: PAM18_2072(atuF) PAM18_2075(atuC)
PNC: NCGM2_3999(mccB) NCGM2_4002
PAEB: NCGM1900_3420 NCGM1900_3423(mccB)
PDK: PADK2_09915 PADK2_09930
PSG: G655_10350 G655_10365
PRP: M062_15470 M062_15485
PAEP: PA1S_10955 PA1S_10970
PAER: PA1R_gp0720 PA1R_gp0723
PAEM: U769_10495 U769_10510
PAEL: T223_10965 T223_10980
PAES: SCV20265_2215 SCV20265_2218
PAEU: BN889_03226(atuC) BN889_03229(atuF)
PAEG: AI22_22900 AI22_22915
PAEC: M802_2988 M802_2991
PAEO: M801_2856 M801_2859
PMY: Pmen_2691 Pmen_2694
PMK: MDS_2024 MDS_2027
PRE: PCA10_37620 PCA10_37650
PPSE: BN5_2435 BN5_2438
PFUW: KF707C_19270 KF707C_19300
PALC: A0T30_09820 A0T30_09835
PCQ: PcP3B5_19970(accA1_1) PcP3B5_20000
PMUI: G4G71_19920 G4G71_19935
PNT: G5B91_21650 G5B91_21665
PPAA: B7D75_10675 B7D75_10690
PFL: PFL_4196(atuC) PFL_4199(atuF)
PPRC: PFLCHA0_c42590(yngE2) PFLCHA0_c42620(accA3)
PPRO: PPC_4293(atuC) PPC_4296(atuF)
PFE: PSF113_1742 PSF113_1744
PFN: HZ99_27640 HZ99_27655
PFO: Pfl01_3947 Pfl01_3950
PFS: PFLU_4394 PFLU_4397
PFC: PflA506_3698(atuC) PflA506_3701(atuF)
PFB: VO64_5139 VO64_5142
PMAN: OU5_1497 OU5_1500
PTV: AA957_22835 AA957_22850
PVR: PverR02_22360 PverR02_22380
PAZO: AYR47_28670
PRX: HRH33_19055 HRH33_19070
PKR: AYO71_21550 AYO71_21565
PMUD: NCTC8068_01872(atuF) NCTC8068_01875
PTOL: I7845_20320 I7845_20335
PFW: PF1751_v1c38890(atuC) PF1751_v1c38920(atuF)
PFF: PFLUOLIPICF716740 PFLUOLIPICF716755
PFX: A7318_18695 A7318_18710
PBA: PSEBR_a1659 PSEBR_a1661
PPUU: PputUW4_01473 PputUW4_01476
PDR: H681_15875 H681_15890
PSK: U771_22880 U771_22895
PKC: PKB_3703(l(2)04524) PKB_3706(MCCC1)
PCH: EY04_21270 EY04_21285
PCZ: PCL1606_19660 PCL1606_19690
PCP: JM49_09920 JM49_09935
PCHP: C4K32_4368 C4K32_4371
PSEM: TO66_22060 TO66_22075
PSOS: POS17_4284(atuC) POS17_4287(atuF)
PFK: PFAS1_02920 PFAS1_02940
PANR: A7J50_4072 A7J50_4075
PSET: THL1_3720 THL1_3723
PSIL: PMA3_07210 PMA3_07225
PYM: AK972_1688 AK972_1691
PKE: DLD99_19830 DLD99_19845
PALL: UYA_10245 UYA_10260
PUM: HGP31_23180 HGP31_23195
POJ: PtoMrB4_17770(atuF) PtoMrB4_17800(atuC)
PGY: AWU82_00330 AWU82_23775
PLAL: FXN65_18455 FXN65_18470
PSEJ: HNQ25_14625 HNQ25_14640
PVK: EPZ47_08995 EPZ47_09005
PBZ: GN234_09410 GN234_09420
PKH: JLK41_10340 JLK41_10355(atuC)
PTY: JWV26_20530 JWV26_20545(atuC)
PMAO: PMYSY11_2043(accA) PMYSY11_2046
PATA: JWU58_09105 JWU58_09120(atuC)
PZE: HU754_020980(atuC) HU754_020995
PMOE: HV782_020180(atuC) HV782_020195
PCAM: HNE05_09990 HNE05_10005
PSEP: C4K39_6114 C4K39_6117
PPII: QL104_21725(atuC) QL104_21740
PVW: HU752_023680(atuC) HU752_023695
PTRT: HU722_0020650(atuC) HU722_0020665
PSAM: HU731_007030(atuC) HU731_007045
PTZ: HU718_021175(atuC) HU718_021190
PSHH: HU773_010435 HU773_010450(atuC)
PHV: HU739_020385 HU739_020400
PASG: KSS96_20300(atuC) KSS96_20315
PAZE: KSS91_08295 KSS91_08310(atuC)
PWZ: J7655_12395(atuC) J7655_12410
PTW: TUM18999_18960(atuF) TUM18999_18990(atuC)
PZA: HU749_009910 HU749_009920(atuC)
PIE: HU724_019805(atuC) HU724_019820
PGF: J0G10_21205(atuC) J0G10_21220
PCAV: D3880_13530 D3880_13545
PHF: NLY38_09535 NLY38_09550(atuC)
PIZ: LAB08_R42950(atuC) LAB08_R42980
PPEG: KUA23_21405(atuC) KUA23_21420
PSII: NF676_18770(atuC) NF676_18785
PFIT: KJY40_20395(atuC) KJY40_20410
PNB: NK667_04915 NK667_04930(atuC)
PSOA: PSm6_39700(atuF) PSm6_39730(atuC)
PKJ: Q1W70_18455 Q1W70_18470(atuC)
PHYG: JTY93_09480 JTY93_09495(atuC)
PHOM: KJF94_17615(atuC) KJF94_17630
PCHE: QYM18_17675 QYM18_17690(atuC)
PCUC: PSH97_19615(atuC) PSH97_19630
PTRL: OU419_19255(atuC) OU419_19270(atuF)
PPAE: LDL65_02145 LDL65_02160
PRHZ: CRX69_13515 CRX69_13525
HPEG: EAO82_15100 EAO82_15115
PDEN: F1C79_13285 F1C79_13300
MAQ: Maqu_2804 Maqu_2807
MHC: MARHY2691 MARHY2695
MAD: HP15_2538 HP15_2542
MSR: AU15_00440
MSX: AU14_06530
MARI: ACP86_03025 ACP86_03040
MLQ: ASQ50_05305 ASQ50_05320
MSQ: BKP64_01770 BKP64_01785
MARA: D0851_06235 D0851_06250
MARJ: MARI_02960(accA1_1) MARI_02990(pccB)
MALL: PBN92_14025 PBN92_14040
MSHE: MAALD49_27810(atuC) MAALD49_27840(atuF)
MANP: EHN06_14585 EHN06_14600
MSAN: LPB19_15770 LPB19_15785
KAK: Kalk_03340 Kalk_03355
ACB: A1S_3005 A1S_3008
ABM: ABSDF2868 ABSDF2871
ABY: ABAYE0480 ABAYE0483
ABC: ACICU_03204 ACICU_03209
ABN: AB57_3456 AB57_3459
ABB: ABBFA_00509(accD5) ABBFA_00512(accA1_1)
ABX: ABK1_3256 ABK1_3259
ABZ: ABZJ_03388 ABZJ_03391
ABR: ABTJ_00491 ABTJ_00494
ABD: ABTW07_3420 ABTW07_3423
ABH: M3Q_3437 M3Q_3440
ABAD: ABD1_28940 ABD1_28970
ABJ: BJAB07104_03293 BJAB07104_03296
ABAB: BJAB0715_03356 BJAB0715_03359
ABAJ: BJAB0868_03249 BJAB0868_03252
ABAZ: P795_2365 P795_2380
ABK: LX00_16125 LX00_16140
ABAU: IX87_11720 IX87_11735
ABAA: IX88_17965 IX88_17980
ABW: BL01_15695 BL01_15710
ABAL: ABLAC_05010
ACC: BDGL_002469(mccC1) BDGL_002472
ANO: RR32_02575 RR32_02590
ALC: OTEC02_02490 OTEC02_02505
ACAL: BUM88_16980 BUM88_16995
ASEI: I8T81_02645 I8T81_02660
ACD: AOLE_02435 AOLE_02450
ACW: A0J50_02380 A0J50_02395
ACV: AMD27_02935 AMD27_02950
AHL: AHTJS_02670 AHTJS_02685
AJN: BVL33_14905 BVL33_14920
ADV: DJ533_05370 DJ533_05385
AWU: BEN71_15675 BEN71_15690
AGU: AS4_37340(liuD) AS4_37370(accD)
ADS: FPL17_17110 FPL17_17125
ABER: BSR55_18360 BSR55_18375
ALJ: G8D99_12450 G8D99_12465
ASHA: G8E00_03470 G8E00_03485
AGYL: FPL18_09795 FPL18_09810
AVZ: HWI77_02515 HWI77_02530
APRL: PY247_02460
ACOI: NQU59_06175 NQU59_06190
AVIV: LF296_15870 LF296_15885
ACIE: KIP84_02585 KIP84_02600
MBAH: HYN46_03580 HYN46_03595
THAT: H3N35_16290 H3N35_16305
TACT: SG35_017185 SG35_017200
TVD: SG34_012000 SG34_012015
PDJ: D0907_20215
AMB: AMBAS45_14990 AMBAS45_15000
GAG: Glaag_3941 Glaag_3943
PAT: Patl_0317 Patl_0319
HMI: soil367_12290 soil367_12305
ALKM: NKI27_15105 NKI27_15120
ASEM: NNL22_11435 NNL22_11450
ALII: QR722_12045 QR722_12055
SAGA: M5M_01905
SNAN: I6N98_02110 I6N98_02120
OSG: BST96_16500 BST96_16510
MICC: AUP74_02722 AUP74_02725(accA1_2)
MII: BTJ40_09625 BTJ40_09640
MICT: FIU95_11165 FIU95_11180(accA2)
MICZ: GL2_32300(mccC1) GL2_32330(atuC)
MVB: MJO52_09440 MJO52_09455
MPAF: R5R33_01285 R5R33_01295
HJA: BST95_14325 BST95_14330
HALC: EY643_07975 EY643_07980
KIM: G3T16_17325 G3T16_17335
AFUS: EYZ66_13120 EYZ66_13130
PAQM: E0F26_06410 E0F26_06420
CYQ: Q91_1219 Q91_1221(accB1)
CZA: CYCME_1207 CYCME_1209
CYY: CPC19_06500 CPC19_06510
HCH: HCH_05748 HCH_05752
HAHE: ENC22_05155 ENC22_05170
HAHH: O5O45_31385 O5O45_31400
ABO: ABO_0986(accA) ABO_0989(accD)
ALN: AS19_10490 AS19_10520
ALCA: ASALC70_04030(accA1_3) ASALC70_04033(pccB)
ADI: B5T_00490 B5T_00491 B5T_01797(accA) B5T_01800(accD)
AXE: P40_02265 P40_02270 P40_08540 P40_08555
APAC: S7S_10290 S7S_10305
TWAN: HUF19_01585 HUF19_01600
OAI: OLEAN_C05730 OLEAN_C05760
BMAR: HF888_06865 HF888_06880
BACZ: KFF03_16420 KFF03_16435
OME: OLMES_1766 OLMES_1769
EMP: EZMO1_3983(atuF) EZMO1_3987(atuC)
SOK: D0B54_13385 D0B54_13395 D0B54_21515 D0B54_21530 D0B54_21675 D0B54_21685
SINI: GT972_02825 GT972_02830
FCE: JN531_011720 JN531_011730
GPB: HDN1F_10690 HDN1F_10720
RPI: Rpic_0106 Rpic_0108
RPF: Rpic12D_0113 Rpic12D_0115
RPJ: N234_26485 N234_26500
RIN: ACS15_0172 ACS15_0174
RWE: KOL96_08515 KOL96_08525
REH: H16_A2142(accA2) H16_A2144(pccB)
CNC: CNE_1c27010(accA4) CNE_1c27040(pccB)
CUH: BJN34_26605 BJN34_26615
REU: Reut_B4460 Reut_B4463
RME: Rmet_1721(pccB) Rmet_1724(accC)
CBW: RR42_s1802 RR42_s1804 RR42_s2502 RR42_s2505
CCUP: BKK81_08300 BKK81_08310 BKK81_26995 BKK81_27010
CUP: BKK80_07610 BKK80_07620 BKK80_29310 BKK80_29325
CUU: BKK79_04520 BKK79_04530 BKK79_35260 BKK79_35275
COX: E0W60_00880 E0W60_00895
CUK: KB879_25955 KB879_25970
BPS: BPSS2031 BPSS2034
BPM: BURPS1710b_A1149 BURPS1710b_A1152
BPL: BURPS1106A_A2774(accB) BURPS1106A_A2777
BPD: BURPS668_A2929 BURPS668_A2932
BPSE: BDL_5454 BDL_5457
BPSM: BBQ_4087 BBQ_4090
BPSU: BBN_5506 BBN_5509
BPSD: BBX_4621 BBX_4624
BPZ: BP1026B_II2185 BP1026B_II2187
BPQ: BPC006_II2739 BPC006_II2742
BPK: BBK_4782 BBK_4785
BPSH: DR55_5687 DR55_5690
BPSA: BBU_3964 BBU_3967
BPSO: X996_5492 X996_5495
BUT: X994_5049 X994_5052
BTE: BTH_II0286 BTH_II0289
BTQ: BTQ_3581 BTQ_3584
BTJ: BTJ_4617 BTJ_4620
BTZ: BTL_5404 BTL_5407
BTD: BTI_4952 BTI_4955
BTV: BTHA_4795 BTHA_4798
BTHE: BTN_5075 BTN_5078
BTHM: BTRA_5343 BTRA_5346
BTHA: DR62_5204 DR62_5207
BTHL: BG87_5411 BG87_5414
BOK: DM82_6350 DM82_6353
BOC: BG90_4321 BG90_4324
BUU: WS70_27675 WS70_27690
BSAV: WS86_29370 WS86_29385
BHG: I6G56_28260 I6G56_28275
BUD: AQ610_30705 AQ610_30720
BUL: BW21_4480 BW21_4483
PMEG: FNZ07_28815 FNZ07_28830
PAND: DRB87_07495
LIMN: HKT17_00910 HKT17_00920
LTO: RGQ30_30280 RGQ30_30300
AXY: AXYL_05145 AXYL_05148 AXYL_05910 AXYL_05912 AXYL_06694 AXYL_06697
APES: FOC84_18890 FOC84_18905
AKA: TKWG_13815 TKWG_13830
PARK: LSG25_19770 LSG25_19775
RFR: Rfer_2815 Rfer_2818
RSB: RS694_04395 RS694_04410
RHY: RD110_23135 RD110_23140
RHF: EUB48_14385 EUB48_14395
RHG: EXZ61_04945 EXZ61_04960
RHOA: HZ993_09215 HZ993_09230
POS: DT070_03200 DT070_03210
POO: F7R28_06225 F7R28_06235
ACK: C380_03315 C380_03335
ACRA: BSY15_2082 BSY15_2086
ARAD: KI609_03505 KI609_03525
AAA: Acav_0072 Acav_0073
VEI: Veis_1895 Veis_1897 Veis_2413 Veis_2415 Veis_4183 Veis_4187
VAP: Vapar_0326 Vapar_0327
VPE: Varpa_0335 Varpa_0336
VPD: VAPA_1c03920 VAPA_1c03930
VBO: CKY39_01850 CKY39_01855
VAM: C4F17_17115 C4F17_17120
CTT: CtCNB1_1718 CtCNB1_1721
CTES: O987_10840 O987_10855
CSER: CCO03_15600
COF: FOZ74_09745 FOZ74_09755
CODO: LAD35_12075 LAD35_12090
CRJ: QMY55_09415 QMY55_09430
ADN: Alide_0010 Alide_0012 Alide_0189 Alide_0192
ADK: Alide2_0015 Alide2_0017 Alide2_0178 Alide2_0181
OTK: C6570_01055 C6570_01065
OTD: J1M35_19035 J1M35_19050
LIH: L63ED372_00596(accA1_1) L63ED372_00600
HYR: BSY239_2831 BSY239_2832 BSY239_339 BSY239_342
HYB: Q5W_03380 Q5W_03390 Q5W_16940 Q5W_16955
HYL: LPB072_21180
HPSE: HPF_03610 HPF_03625(accA1) HPF_12725 HPF_12730(accA2)
HYN: F9K07_05770 F9K07_05780
HTN: KI616_23285 KI616_23300
HCZ: G9Q37_12940 G9Q37_12955
DIH: G7047_04285 G7047_04295
DAER: H9K75_04785 H9K75_04795
SIMP: C6571_04750 C6571_04760 C6571_17625 C6571_17640
MELM: C7H73_12855 C7H73_12870
MELA: C6568_08040 C6568_08050
MJE: LVC68_00795 LVC68_00805
STHM: IS481_02945 IS481_02955
RGE: RGE_32870 RGE_32900
RBN: RBXJA2T_12964 RBXJA2T_12979
KIA: G8A07_05690 G8A07_05700
PKT: AT984_14390 AT984_14405
NOK: FAY22_17150 FAY22_17160
ETB: N7L95_01835 N7L95_01845
SHD: SUTH_02873 SUTH_02876
DDZ: DSYM_01610 DSYM_01630
NIY: FQ775_21500
PMOB: HG718_07160 HG718_07170
PECT: BN1012_Phect2899 BN1012_Phect2901
BJA: blr0986(mccB) blr0987(mccA)
BJU: BJ6T_10100 BJ6T_10110
BJP: RN69_04930 RN69_04935
BRA: BRADO6875 BRADO6876
BBT: BBta_0675 BBta_0676
BRS: S23_68190(mccA) S23_68200(mccB)
AOL: S58_05990 S58_06010
BRC: BCCGELA001_34720 BCCGELA001_34725
BRAD: BF49_7199 BF49_7200
BIC: LMTR13_36825 LMTR13_36830
BRO: BRAD285_7008 BRAD285_7009
BRK: CWS35_08880 CWS35_08885
BOT: CIT37_09365 CIT37_09370
BRQ: CIT40_30525 CIT40_30530
BGQ: X265_35105 X265_35110
BGZ: XH91_33455 XH91_33460
BSYM: CIT39_29630 CIT39_29635
BBET: F8237_13440 F8237_13445
BARH: WN72_46665 WN72_46670
BVZ: BRAD3257_8743(mccA) BRAD3257_8744
BEL: BE61_03480(mccA) BE61_03490(mccB)
BDG: LPJ38_02585 LPJ38_02590
BSEP: HAP48_0013175 HAP48_0013180
BQB: J4P68_0017025 J4P68_0017030
BSEI: KMZ68_02880 KMZ68_02885
BBAN: J4G43_051140 J4G43_051145
BCAN: BcanWSM471_35890 BcanWSM471_35895
BAUT: QA635_03160 QA635_03165
BBRA: QA636_03190 QA636_03195
BGK: IC762_34735 IC762_34740
BCOU: IC761_35065 IC761_35070
BPAH: QA639_03125 QA639_03130
BXN: I3J27_38050 I3J27_38055
BROS: QUH67_02840 QUH67_02845
BRAZ: LRP30_01900 LRP30_01905
RPA: TX73_011055 TX73_011060
RPB: RPB_3259 RPB_3260
RPC: RPC_3200 RPC_3201
RPD: RPD_2204 RPD_2205
RPE: RPE_2254 RPE_2255
RPT: Rpal_2435 Rpal_2436
RPX: Rpdx1_3381 Rpdx1_3382
RVA: Rvan_0552 Rvan_3447
RLAC: QMO75_05670 QMO75_13205
RBM: TEF_07385 TEF_16790
PSF: PSE_4597 PSE_4599
PHR: C6569_18955 C6569_18960
PSTG: E8M01_13240 E8M01_13245 E8M01_29610 E8M01_29615
PAQT: E8L99_06845 E8L99_06850
SIL: SPO0578 SPO0579
LAQU: R2C4_13395 R2C4_13400
LCAE: K3721_03670 K3721_03675
TGL: HFZ77_00685 HFZ77_00690
HML: HmaOT1_18785 HmaOT1_18790
THAS: C6Y53_03710 C6Y53_03715
HDH: G5B40_00895 G5B40_00905
GAK: X907_0619 X907_0622
SECH: B18_27400 B18_27415
SPHG: AZE99_15805 AZE99_15815
SFLA: SPHFLASMR4Y_02317(accA1) SPHFLASMR4Y_02319
SPHY: CHN51_05350 CHN51_05360
PARJ: J4G78_10635 J4G78_10645
PHAO: HF685_10670 HF685_10680
RCE: RC1_3531 RC1_3533
FER: FNB15_07225 FNB15_07235
TMO: TMO_a0453 TMO_a0454
HFL: PUV54_00650 PUV54_00665
SNEA: NBZ79_02300 NBZ79_05710 NBZ79_05715 NBZ79_16375 NBZ79_16380
KOZ: KFF44_13260 KFF44_13265
GSO: PH603_16430 PH603_16445
MXA: MXAN_0081(accB) MXAN_0082(accC)
MSD: MYSTI_00076 MYSTI_00077
MYM: A176_006936 A176_006937
MFB: MFUL124B02_00485 MFUL124B02_00490
MYX: QEG98_00425 QEG98_00430
CCX: COCOR_03097(accB) COCOR_03098(accC1)
MFU: LILAB_08345 LILAB_08350
MMAS: MYMAC_000087 MYMAC_000088
AGE: AA314_07788 AA314_07789
AVM: JQX13_26715 JQX13_26720
NANN: O0S08_37795 O0S08_37810
PIJ: QEJ31_14290
EUZ: DVS28_a3277 DVS28_a3278
TSD: MTP03_45900 MTP03_45920(atuF)
SCOR: J3U87_30225 J3U87_30240
FAX: FUAX_29810
PPSV: PEPS_22610(liuD)
 » show all
Reference
1  [PMID:14087299]
  Authors
SEUBERT W, FASS E, REMBERGER U.
  Title
[STUDIES ON THE BACTERIAL DEGRADATION OF ISOPRENOID COMPOUNDS. III. PURIFICATION AND PROPERTIES OF GERANYL CARBOXYLASE.]
  Journal
Biochem Z 338:265-75 (1963)
Other DBs
ExplorEnz - The Enzyme Database: 6.4.1.5
IUBMB Enzyme Nomenclature: 6.4.1.5
ExPASy - ENZYME nomenclature database: 6.4.1.5
UM-BBD (Biocatalysis/Biodegradation Database): 6.4.1.5
BRENDA, the Enzyme Database: 6.4.1.5
CAS: 37324-35-9
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