ERK signaling |
| | | | | | | | | | | | | | D4 | | | | | |
N00001 |
|
EGF | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK | → | CCND1 |
| | | | | | | | | | | | | | D4 | | | | | |
N00014 |
|
| | EGFR* | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK | → | CCND1 |
| | | | | | | | | | | | | | D4 | | | |
N00041 |
|
| | EGFR* | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
| | | | | | | | | | | | | | D4 | | | |
N00022 |
|
EGF | → | (ERBB2*+EGFR) | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
| | | | | | | | D5,D6 | | | | | | | D4 | | | |
N00008 |
|
| | | | | | RET* | → | RAS | → | RAF | → | MEK | → | ERK |
| | | | | | | | | | | | | | D4 | | | | | |
N00007 |
|
| | | | | | EML4-ALK | → | RAS | → | RAF | → | MEK | → | ERK | → | CCND1 |
| | | | | | | | | | D1 | | | | | D4 | | | | | |
N00012 |
|
| | | | | | | | (KRAS*,NRAS*) | → | RAF | → | MEK | → | ERK | → | CCND1 |
| | | | | | | | | | | | | | D4 | | | |
N00216 |
|
HGF | → | MET | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
| | | | D2,D3 | | | | | | | | | | | D4 | | | |
N01062 |
|
| | MET* | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
Calcium signaling |
| | | | | | | | | | | | | | | | D4 | | | | | |
N00023 |
|
EGF | → | EGFR | → | PLCG | → | IP3 | → | (Ca2+,DAG) | → | PKC | → | RAF | → | MEK | → | ERK | → | CCND1 |
| | | | | | | | | | | | | | | | D4 | | | | | |
N00024 |
|
| | EGFR* | → | PLCG | → | IP3 | → | (Ca2+,DAG) | → | PKC | → | RAF | → | MEK | → | ERK | → | CCND1 |
| | | | | | | | | | | | | | | | D4 | | | | | |
N00025 |
|
| | EML4-ALK | → | PLCG | → | IP3 | → | (Ca2+,DAG) | → | PKC | → | RAF | → | MEK | → | ERK | → | CCND1 |
PI3K signaling |
N00033 |
|
EGF | → | EGFR | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
N00036 |
|
| | EGFR* | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
N00047 |
|
| | EML4-ALK | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
| | | | D1 | | | | | | | | | |
N00032 |
|
| | (KRAS*,NRAS*) | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
N00043 |
|
HGF | → | MET | → | GAB1 | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
| | | | D2,D3 | | | | | | | | | | | |
N01063 |
|
| | MET* | → | GAB1 | → | PI3K | → | PIP3 | → | AKT | → | MTOR |
Other RAS signaling |
N00096 |
|
EGF | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | (RASSF1+RASSF5) | → | STK4 |
N00097 |
|
| | | | | | | | RAS | ⌿ | (RASSF1*+RASSF5) | ⌿ | STK4 |
JAK-STAT signaling |
N00053 |
|
Cytokine | → | Receptor | → | JAK | → | STAT | ⇒ | PIM1 |
N00105 |
|
| | EML4-ALK | → | JAK3 | → | STAT3,STAT5 |
Cell cycle |
N00066 |
|
CDKN2A | ⊣ | MDM2 | ⊣ | TP53 | ⇒ | CDKN1A | ⊣ | (CCND+CDK4/6) | → | RB1 | ⌿ | E2F |
N00070 |
|
| | | | | | CDKN2A* | ⌿ | (CCND+CDK4/6) | → | RB1 | ⌿ | E2F |
Transcription |
N00115 |
|
TP53* | ⌿ | (CDKN1A,GADD45,BAX.. |
|