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ENTRY	nt06276
Name	Chronic myeloid leukemia
Category	Disease view; Cancer
Pathway	hsa05220 Chronic myeloid leukemia
Disease	H00004 Chronic myeloid leukemia
Display	drug-target relation   disease type

ERK signaling                                   D7  | N00001    EGF → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1       D1,D2,D3,D4,D5,D6  |                         N00002        BCR-ABL → GRB2 → SOS → RAS → RAF → MEK → ERK PI3K signaling N00033    EGF → EGFR → PI3K → PIP3 → AKT ⊣ BAD   D1,D2,D3,D4,D5,D6  |                     N00048    BCR-ABL → (CRKL+CBL+CRK) → PI3K → PIP3 → AKT ⊣ BAD TGFB signaling N00063    TGFB → (TGFBR2+TGFBR1) → (SMAD2,SMAD3) = SMAD4 N00106        AML1-EVI1 ⊣ SMAD3 = SMAD4 N00107        EVI1* ⊣ SMAD3 = SMAD4 JAK-STAT signaling N00053    Cytokine → Receptor → JAK → STAT ⇒ PIM1           D1,D2,D3,D4,D5,D6  |         N00055            BCR-ABL → STAT5 ⇒ BCL2L1 Cell cycle                   D7  |         N00066    CDKN2A ⊣ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F                   D7  |         N00067    CDKN2A* ⌿ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F                   D7  |         N00070                CDKN2A* ⌿ (CCND+CDK4/6) → RB1 ⌿ E2F N00074                        RB1* ⌿ E2F Transcription N00115    TP53* ⌿ (CDKN1A,GADD45,BAX..

		Drug name
D1	D01441	Imatinib mesylate (USAN)
D2	D06413	Nilotinib hydrochloride hydrate (JAN)
D3	D06414	Dasatinib (USAN)
D4	D09728	Bosutinib hydrate (JAN)
D5	D09951	Ponatinib hydrochloride (JAN/USAN)
D6	D11404	Asciminib hydrochloride (JAN/USAN)
D7	D08956	Omacetaxine mepesuccinate (USAN)