Network variation - Chronic myeloid leukemia
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ENTRY
nt06276
Name
Chronic myeloid leukemia
Category
Disease view; Cancer
Pathway
hsa05220
Chronic myeloid leukemia
Disease
H00004
Chronic myeloid leukemia
Display
drug-target relation
disease type
ERK signaling
N00001
EGF
→
EGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
→
CCND1
N00002
BCR-ABL
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
PI3K signaling
N00033
EGF
→
EGFR
→
PI3K
→
PIP3
→
AKT
⊣
BAD
N00048
BCR-ABL
→
(
CRKL
+
CBL
+
CRK
)
→
PI3K
→
PIP3
→
AKT
⊣
BAD
TGFB signaling
N00063
TGFB
→
(TGFBR2+TGFBR1)
→
(SMAD2,SMAD3)
=
SMAD4
N00106
AML1-EVI1
⊣
SMAD3
=
SMAD4
N00107
EVI1*
⊣
SMAD3
=
SMAD4
JAK-STAT signaling
N00053
Cytokine
→
Receptor
→
JAK
→
STAT
⇒
PIM1
N00055
BCR-ABL
→
STAT5
⇒
BCL2L1
Cell cycle
N00066
CDKN2A
⊣
MDM2
⊣
TP53
⇒
CDKN1A
⊣
(CCND+CDK4/6)
→
RB1
⌿
E2F
N00067
CDKN2A*
⌿
MDM2
⊣
TP53
⇒
CDKN1A
⊣
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00070
CDKN2A*
⌿
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00074
RB1*
⌿
E2F
Transcription
N00115
TP53*
⌿
(
CDKN1A
,
GADD45
,
BAX..