| Entry |
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| Name |
Mefenamic acid (JP18/USP/INN);
Ponstel (TN) |
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| Product |
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| Generic |
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| Formula |
C15H15NO2
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| Exact mass |
241.1103
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| Mol weight |
241.28
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01911 Anti-inflammatory drug, fenamic acid derivatives
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
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| Remark |
| Therapeutic category: | 1141 |
|
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| Efficacy |
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor |
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| Comment |
Aniline derivative, Fenamic acid derivative
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AG Fenamates
M01AG01 Mefenamic acid
D00151 Mefenamic acid (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Analgesics
Nonsteroidal Anti-inflammatory Drugs
Mefenamic Acid
D00151 Mefenamic acid (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
114 Antipyretics and analgesics, anti-inflammatory agents
1141 Anilines
D00151 Mefenamic acid (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01911 Anti-inflammatory drug, fenamic acid derivatives
D00151 Mefenamic acid
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
D00151 Mefenamic acid
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D00151 Mefenamic acid
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D00151 Mefenamic acid (JP18/USP/INN) <JP/US>
PTGS2 (COX2)
D00151 Mefenamic acid (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00151 Mefenamic acid
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00151
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 18
1 C8x C 16.5885 -16.4952
2 C8y C 16.5885 -15.0954
3 C8y C 15.3763 -14.3954
4 C8x C 14.1639 -15.0954
5 C8x C 14.1639 -16.4952
6 C8x C 15.3763 -17.1951
7 C6a C 15.3763 -12.9956
8 O6a O 14.1633 -12.2953
9 O6a O 16.5878 -12.2961
10 N1b N 17.8008 -14.3954
11 C8y C 19.0137 -15.0958
12 C8x C 19.0137 -16.4952
13 C8x C 20.2260 -17.1951
14 C8x C 21.4384 -16.4952
15 C8y C 21.4384 -15.0958
16 C8y C 20.2260 -14.3958
17 C1a C 20.2261 -12.9956
18 C1a C 22.6530 -14.3944
BOND 19
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 3 7 1
8 7 8 2
9 7 9 1
10 2 10 1
11 10 11 1
12 11 12 1
13 12 13 2
14 13 14 1
15 14 15 2
16 15 16 1
17 11 16 2
18 16 17 1
19 15 18 1
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