KEGG   DRUG: Methimazole
Entry
D00401                      Drug                                   
Name
Methimazole (USP);
Thiamazole (JP18/INN);
Tapazole (TN)
Product
  Generic
METHIMAZOLE (A-S Medication Solutions), METHIMAZOLE (American Health Packaging), METHIMAZOLE (Bionpharma), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Chartwell RX), METHIMAZOLE (Golden State Medical Supply), METHIMAZOLE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), METHIMAZOLE (Macleods Pharmaceuticals Limited), METHIMAZOLE (NORTHSTAR RX LLC), METHIMAZOLE (Par Pharmaceutical), METHIMAZOLE (Preferred Pharmaceuticals), METHIMAZOLE (Preferred Pharmaceuticals), METHIMAZOLE (REMEDYREPACK), METHIMAZOLE (REMEDYREPACK), METHIMAZOLE (Rising Pharmaceuticals), METHIMAZOLE (Strides Pharma Science Limited), METHIMAZOLE (Upsher-Smith Laboratories)
Formula
C4H6N2S
Exact mass
114.0252
Mol weight
114.17
Structure
Simcomp
Class
Hormonal agent
 DG01934  Antithyroid agent
Remark
Same as: C07190
Therapeutic category: 2432
ATC code: H03BB02
Product: D00401<JP/US>
Efficacy
Antithyroid, Thyroid hormone synthesis inhibitor
  Disease
Graves' disease [DS:H00082]
Hyperthyroidism [DS:H01645]
Target
TPO [HSA:7173] [KO:K00431]
  Pathway
hsa04918  Thyroid hormone synthesis
  Network
nt06322  TRH-TSH-TH signaling
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H03 THYROID THERAPY
   H03B ANTITHYROID PREPARATIONS
    H03BB Sulfur-containing imidazole derivatives
     H03BB02 Thiamazole
      D00401  Methimazole (USP) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Suppressant (Thyroid)
  Antithyroid Agents
   Methimazole
    D00401  Methimazole (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   243  Thyroid and parathyroid hormone preparations
    2432  Antithyroid hormones
     D00401  Methimazole (USP); Thiamazole (JP18/INN)
Drug groups [BR:br08330]
 Hormonal agent
  DG01934  Antithyroid agent
   D00401  Methimazole
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Peroxidase
    TPO
     D00401  Methimazole (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00401  Thiamazole
  D00401  Thiamazole tablets
Other DBs
CAS: 60-56-0
PubChem: 7847467
ChEBI: 50673
PDB-CCD: MMZ[PDBj]
LigandBox: D00401
NIKKAJI: J1.400A
LinkDB
KCF data

ATOM        7
            1   C8y C    26.1871  -18.2805
            2   N4y N    25.7487  -19.6075
            3   N4x N    25.0529  -17.4502
            4   S0  S    27.5142  -17.8478
            5   C8x C    24.3513  -19.6075
            6   C1a C    26.5730  -20.7418
            7   C8x C    23.9186  -18.2805
BOND        7
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     5   7 2

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