 | | DRUG: Quetiapine fumarate | |
| Entry |
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| Name |
Quetiapine fumarate (JP18/USP);
Seroquel (TN) |
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| Product |
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| Generic |
QUETIAPINE (A-S Medication Solutions), QUETIAPINE (A-S Medication Solutions), QUETIAPINE (A-S Medication Solutions), QUETIAPINE (ACI Healthcare USA), QUETIAPINE (Accord Healthcare), QUETIAPINE (Advanced Rx Pharmacy of Tennessee), QUETIAPINE (Advanced Rx Pharmacy of Tennessee), QUETIAPINE (Amneal Pharmaceuticals LLC), QUETIAPINE (Aphena Pharma Solutions - Tennessee), QUETIAPINE (AvKARE), QUETIAPINE (BluePoint Laboratories), QUETIAPINE (Bryant Ranch Prepack), QUETIAPINE (Bryant Ranch Prepack), QUETIAPINE (Bryant Ranch Prepack), QUETIAPINE (Bryant Ranch Prepack), QUETIAPINE (Bryant Ranch Prepack), QUETIAPINE (Bryant Ranch Prepack), QUETIAPINE (Golden State Medical Supply), QUETIAPINE (Macleods Pharmaceuticals Limited), QUETIAPINE (NCS HealthCare of KY), QUETIAPINE (NCS HealthCare of KY), QUETIAPINE (Northstar RxLLC), QUETIAPINE (PD-Rx Pharmaceuticals), QUETIAPINE (Preferred Pharmaceuticals), QUETIAPINE (Proficient Rx LP), QUETIAPINE (Proficient Rx LP), QUETIAPINE (Proficient Rx LP), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (RPK Pharmaceuticals), QUETIAPINE (RPK Pharmaceuticals), QUETIAPINE (RPK Pharmaceuticals), QUETIAPINE (ScieGen Pharmaceuticals), QUETIAPINE (Solco Healthcare U.S.), QUETIAPINE (Solco Healthcare US), QUETIAPINE (Teva Pharmaceuticals USA), QUETIAPINE (Unichem Pharmaceuticals (USA)), QUETIAPINE FUMARATE (A-S Medication Solutions), QUETIAPINE FUMARATE (A-S Medication Solutions), QUETIAPINE FUMARATE (A-S Medication Solutions), QUETIAPINE FUMARATE (A-S Medication Solutions), QUETIAPINE FUMARATE (A-S Medication Solutions), QUETIAPINE FUMARATE (A-S Medication Solutions), QUETIAPINE FUMARATE (A-S Medication Solutions), QUETIAPINE FUMARATE (Accord Healthcare), QUETIAPINE FUMARATE (Accord Healthcare), QUETIAPINE FUMARATE (Advanced Rx Pharmacy of Tennessee), QUETIAPINE FUMARATE (Advanced Rx Pharmacy of Tennessee), QUETIAPINE FUMARATE (Alembic Pharmaceuticals Limited), QUETIAPINE FUMARATE (American Health Packaging), QUETIAPINE FUMARATE (Aphena Pharma Solutions - Tennessee), QUETIAPINE FUMARATE (Aphena Pharma Solutions - Tennessee), QUETIAPINE FUMARATE (Aphena Pharma Solutions - Tennessee), QUETIAPINE FUMARATE (Ascend Laboratories), QUETIAPINE FUMARATE (Aurobindo Pharma Limited), QUETIAPINE FUMARATE (Aurobindo Pharma Limited), QUETIAPINE FUMARATE (AvPAK), QUETIAPINE FUMARATE (BluePoint Laboratories), QUETIAPINE FUMARATE (Bluepoint Laboratories), QUETIAPINE FUMARATE (Bluepoint Laboratories), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Camber Pharmaceuticals), QUETIAPINE FUMARATE (Cardinal Health 107), QUETIAPINE FUMARATE (Direct Rx), QUETIAPINE FUMARATE (Direct_Rx), QUETIAPINE FUMARATE (Direct_Rx), QUETIAPINE FUMARATE (Direct_Rx), QUETIAPINE FUMARATE (Direct_Rx), QUETIAPINE FUMARATE (Direct_Rx), QUETIAPINE FUMARATE (Dr.Reddy's Laboratories Limited), QUETIAPINE FUMARATE (Golden State Medical Supply), QUETIAPINE FUMARATE (Golden State Medical Supply), QUETIAPINE FUMARATE (Ingenus Pharmaceuticals), QUETIAPINE FUMARATE (Lupin Pharmaceuticals), QUETIAPINE FUMARATE (Lupin Pharmaceuticals), QUETIAPINE FUMARATE (Macleods Pharmaceuticals Limited), QUETIAPINE FUMARATE (Major Pharmaceuticals), QUETIAPINE FUMARATE (Major Pharmaceuticals), QUETIAPINE FUMARATE (NCS HealthCare of KY), QUETIAPINE FUMARATE (NorthStar Rx LLC), QUETIAPINE FUMARATE (NuCare Pharmaceuticals), QUETIAPINE FUMARATE (NuCare Pharmaceuticals), QUETIAPINE FUMARATE (NuCare Pharmaceuticals), QUETIAPINE FUMARATE (NuCare Pharmaceuticals), QUETIAPINE FUMARATE (NuCare Pharmaceuticals), QUETIAPINE FUMARATE (NuCare Pharmaceuticals), QUETIAPINE FUMARATE (PD-Rx Pharmaceuticals), QUETIAPINE FUMARATE (Preferred Pharmaceuticals), QUETIAPINE FUMARATE (Preferred Pharmaceuticals), QUETIAPINE FUMARATE (Preferred Pharmaceuticals), QUETIAPINE FUMARATE (Preferred Pharmaceuticals), QUETIAPINE FUMARATE (Preferred Pharmaceuticals), QUETIAPINE FUMARATE (Preferred Pharmaceuticals), QUETIAPINE FUMARATE (Preferred Pharmaceuticals), QUETIAPINE FUMARATE (Proficient Rx LP), QUETIAPINE FUMARATE (Proficient Rx LP), QUETIAPINE FUMARATE (Proficient Rx LP), QUETIAPINE FUMARATE (Proficient Rx LP), QUETIAPINE FUMARATE (Proficient Rx LP), QUETIAPINE FUMARATE (Proficient Rx LP), QUETIAPINE FUMARATE (Proficient Rx LP), QUETIAPINE FUMARATE (Quality Care Products), QUETIAPINE FUMARATE (Quality Care Products), QUETIAPINE FUMARATE (Quallent Pharmaceuticals Health LLC), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (RPK Pharmaceuticals), QUETIAPINE FUMARATE (Rising Pharma Holdings), QUETIAPINE FUMARATE (Sun Pharmaceutical Industries), QUETIAPINE FUMARATE (Unichem Pharmaceuticals (USA)), QUETIAPINE FUMARATE (West-Ward Pharmaceuticals Corp), QUETIAPINE FUMARATE (XLCare Pharmaceuticals), QUETIAPINE FUMARATE ER (Direct_Rx), QUETIAPINE FUMARATE ER (Direct_Rx), QUETIAPINE FUMARATE ER (Direct_Rx), QUETIAPINE FUMARATE ER (Direct_Rx) |
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| Formula |
(C21H25N3O2S)2. C4H4O4
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| Exact mass |
882.3445
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| Mol weight |
883.0864
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| Structure |
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| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG03064 Atypical antipsychotic
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Therapeutic category: | 1179 |
| Product (DG00899): | D00458<JP/US> |
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| Efficacy |
Antipsychotic |
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| Disease |
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| Comment |
Multi-acting-receptor-targeting-antipsychotics (MARTA)
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| map07213 | Dopamine receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AH Diazepines, oxazepines, thiazepines and oxepines
N05AH04 Quetiapine
D00458 Quetiapine fumarate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antidepressants
Antidepressants, Other
Quetiapine
D00458 Quetiapine fumarate (JP18/USP)
Antipsychotics
2nd Generation/Atypical
Quetiapine
D00458 Quetiapine fumarate (JP18/USP)
Bipolar Agents
Bipolar Agents, Other
Quetiapine
D00458 Quetiapine fumarate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D00458 Quetiapine fumarate (JP18/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00899 Quetiapine
D00458 Quetiapine fumarate
DG03200 Antipsychotic agent
DG03064 Atypical antipsychotic
DG00899 Quetiapine
D00458 Quetiapine fumarate
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00899 Quetiapine
D00458 Quetiapine fumarate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00899 Quetiapine
D00458 Quetiapine fumarate
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D00458 Quetiapine fumarate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D00458 Quetiapine fumarate (JP18/USP) <JP/US>
Serotonin
HTR2A
D00458 Quetiapine fumarate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00458 Quetiapine fumarate
D00458 Quetiapine fumarate tablets
D00458 Quetiapine fumarate fine granules
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00458
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00458
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00899 Quetiapine
DG03200 Antipsychotic agent
DG03064 Atypical antipsychotic
DG00899 Quetiapine
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00899 Quetiapine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00899 Quetiapine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 62
1 C6a C 22.4475 -22.4692
2 C2b C 23.6586 -23.1712
3 O6a O 21.2365 -23.1712
4 O6a O 22.4475 -21.0711
5 C2b C 24.8753 -22.4692
6 C6a C 26.0863 -23.1712
7 O6a O 27.2973 -22.4692
8 O6a O 26.0863 -24.5693
9 C8y C 16.3800 -19.7400
10 N2x N 15.5400 -20.8600
11 C2y C 14.1400 -20.8600
12 C8y C 13.2300 -19.8100
13 C8y C 16.1000 -18.4100
14 C8y C 13.5100 -18.4100
15 S2x S 14.7700 -17.7800
16 C8x C 12.4600 -17.5000
17 C8x C 11.1300 -17.9200
18 C8x C 10.8500 -19.3200
19 C8x C 11.9000 -20.2300
20 C8x C 17.7800 -20.1600
21 C8x C 18.7600 -19.1800
22 C8x C 18.4100 -17.7800
23 C8x C 17.0800 -17.4300
24 N1y N 13.5100 -22.1200
25 C1x C 12.1800 -22.2600
26 C1x C 11.5500 -23.5200
27 N1y N 12.3900 -24.7100
28 C1x C 13.7200 -24.5700
29 C1x C 14.3500 -23.3100
30 C1b C 11.8300 -25.9700
31 C1b C 10.4300 -25.9700
32 O2a O 9.7300 -24.7800
33 C1b C 8.3300 -24.7800
34 C1b C 7.6300 -23.5900
35 O1a O 6.2300 -23.5900
36 C8y C 16.3800 -19.7400
37 C8y C 16.1000 -18.4100
38 S2x S 14.7700 -17.7800
39 C8y C 13.5100 -18.4100
40 C8y C 13.2300 -19.8100
41 C2y C 14.1400 -20.8600
42 N2x N 15.5400 -20.8600
43 N1y N 13.5100 -22.1200
44 C1x C 12.1800 -22.2600
45 C1x C 11.5500 -23.5200
46 N1y N 12.3900 -24.7100
47 C1x C 13.7200 -24.5700
48 C1x C 14.3500 -23.3100
49 C1b C 11.8300 -25.9700
50 C1b C 10.4300 -25.9700
51 O2a O 9.7300 -24.7800
52 C1b C 8.3300 -24.7800
53 C1b C 7.6300 -23.5900
54 O1a O 6.2300 -23.5900
55 C8x C 11.9000 -20.2300
56 C8x C 10.8500 -19.3200
57 C8x C 11.1300 -17.9200
58 C8x C 12.4600 -17.5000
59 C8x C 17.0800 -17.4300
60 C8x C 18.4100 -17.7800
61 C8x C 18.7600 -19.1800
62 C8x C 17.7800 -20.1600
BOND 67
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 2
5 5 6 1
6 6 7 1
7 6 8 2
8 11 12 1
9 9 13 1
10 12 14 1
11 10 11 2
12 13 15 1
13 9 10 1
14 14 15 1
15 14 16 2
16 16 17 1
17 17 18 2
18 18 19 1
19 12 19 2
20 9 20 2
21 20 21 1
22 21 22 2
23 22 23 1
24 13 23 2
25 11 24 1
26 24 25 1
27 25 26 1
28 26 27 1
29 27 28 1
30 28 29 1
31 24 29 1
32 27 30 1
33 30 31 1
34 31 32 1
35 32 33 1
36 33 34 1
37 34 35 1
38 41 40 1
39 36 37 1
40 40 39 1
41 42 41 2
42 37 38 1
43 36 42 1
44 39 38 1
45 39 58 2
46 58 57 1
47 57 56 2
48 56 55 1
49 40 55 2
50 36 62 2
51 62 61 1
52 61 60 2
53 60 59 1
54 37 59 2
55 41 43 1
56 43 44 1
57 44 45 1
58 45 46 1
59 46 47 1
60 47 48 1
61 43 48 1
62 46 49 1
63 49 50 1
64 50 51 1
65 51 52 1
66 52 53 1
67 53 54 1
BRACKET 1 4.4800 -26.8800 4.4800 -16.8000
1 19.1800 -16.8000 19.1800 -26.8800
1 2
ORIGINAL 1 9 13 15 14 12 11 10 24 25 26 27 28 29 30 31 32
1 33 34 35 19 18 17 16 23 22 21 20
REPEAT 1 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51
1 52 53 54 55 56 57 58 59 60 61 62
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