 | | DRUG: Benazepril hydrochloride | |
| Entry |
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| Name |
Benazepril hydrochloride (JAN/USP);
Lotensin (TN) |
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| Product |
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| Generic |
BENAZEPRIL (Direct_Rx), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (Amneal Pharmaceuticals LLC), BENAZEPRIL HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), BENAZEPRIL HYDROCHLORIDE (Aurobindo Pharma Limited), BENAZEPRIL HYDROCHLORIDE (AvPAK), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Cardinal Health 107), BENAZEPRIL HYDROCHLORIDE (Chartwell RX), BENAZEPRIL HYDROCHLORIDE (DIRECT RX), BENAZEPRIL HYDROCHLORIDE (Golden State Medical Supply), BENAZEPRIL HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Northwind Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Northwind Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Northwind Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Northwind Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Northwind Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Northwind Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticlas), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (RPK Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (RPK Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Solco healthcare U.S.), BENAZEPRIL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), BENAZEPRIL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), BENAZEPRIL HYDROCHLORIDE (Zydus Lifesciences Limited) |
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| Formula |
C24H28N2O5. HCl
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| Exact mass |
460.1765
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| Mol weight |
460.9505
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
Metabolizing enzyme substrate
DG02924 UGT substrate
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| Remark |
| Therapeutic category: | 2144 |
| Product (DG00339): | D00620<JP/US> |
| Product (mixture): | D10279<US> D11069<US> |
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| Efficacy |
Antihypertensive, Angiotensin-converting enzyme inhibitor |
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| Disease |
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| Comment |
Active form of prodrug: Benazeprilat [DR: D03077]
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| Target |
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| Pathway |
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| Metabolism |
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| Interaction |
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| Structure map |
| map07217 | Renin-angiotensin system inhibitors |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
C09A ACE INHIBITORS, PLAIN
C09AA ACE inhibitors, plain
C09AA07 Benazepril
D00620 Benazepril hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Angiotensin-converting Enzyme (ACE) Inhibitors
Benazepril
D00620 Benazepril hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2144 Angiotensin converting enzyme inhibitors
D00620 Benazepril hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG00339 Benazepril
D00620 Benazepril hydrochloride
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
DG00339 Benazepril
D00620 Benazepril hydrochloride
Metabolizing enzyme substrate
DG02924 UGT substrate
DG00339 Benazepril
D00620 Benazepril hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG01501 Angiotensin-converting enzyme inhibitor
D00620 Benazepril hydrochloride
DG03231 Antihypertensive
D00620 Benazepril hydrochloride
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Peptidyl-dipeptidases
ACE (CD143)
D00620 Benazepril hydrochloride (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00620
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG00339 Benazepril
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
DG00339 Benazepril
Metabolizing enzyme substrate
DG02924 UGT substrate
DG00339 Benazepril
Prodrugs [br08324.html]
DG00339
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 32
1 C1x C 23.3231 -19.6615
2 C8y C 22.4372 -18.5840
3 C8y C 22.7197 -17.2133
4 N1y N 23.9591 -16.5857
5 C1x C 24.7308 -19.7019
6 C5x C 25.2377 -17.1596
7 C1y C 25.5777 -18.5180
8 C8x C 21.6743 -16.2838
9 C8x C 20.3466 -16.7242
10 C8x C 20.0641 -18.0949
11 C8x C 21.1095 -19.0246
12 C1b C 23.9262 -15.1817
13 C6a C 25.1248 -14.4519
14 O6a O 26.3615 -15.1276
15 O6a O 25.1625 -13.0836
16 O5x O 26.3330 -16.2423
17 N1b N 26.9766 -18.5180
18 C1c C 27.6929 -19.7595
19 C1b C 29.1069 -19.7602
20 C7a C 27.0102 -20.9405
21 C1b C 29.8213 -18.5252
22 C8y C 31.2056 -18.5264
23 O6a O 25.6102 -20.9399
24 O7a O 27.6989 -22.1343
25 C1b C 29.1070 -22.1349
26 C1a C 29.7937 -23.3254
27 C8x C 31.9096 -19.7481
28 C8x C 33.3085 -19.7492
29 C8x C 34.0091 -18.5383
30 C8x C 33.3051 -17.3167
31 C8x C 31.9062 -17.3155
32 X Cl 34.6331 -22.3162
BOND 33
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 4 12 1
14 12 13 1
15 13 14 1
16 13 15 2
17 6 16 2
18 7 17 1 #Up
19 17 18 1
20 18 19 1 #Up
21 18 20 1
22 19 21 1
23 21 22 1
24 20 23 2
25 20 24 1
26 24 25 1
27 25 26 1
28 22 27 2
29 27 28 1
30 28 29 2
31 29 30 1
32 30 31 2
33 22 31 1
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