KEGG   DRUG: Dopamine hydrochloride
Entry
D00633                      Drug                                   
Name
Dopamine hydrochloride (JP18/USP);
Actopamin (TN);
Intropin (TN)
Product
DOPAMINE HCI (HF Acquisition Co LLC), DOPAMINE HCI (HF Acquisition Co. LLC), DOPAMINE HCI IN 5% DEXTROSE (HF Acquisition Co LLC), DOPAMINE HYDROCHLORIDE (HF Acquisition Co LLC), DOPAMINE HYDROCHLORIDE (Henry Schein), DOPAMINE HYDROCHLORIDE (Henry Schein), DOPAMINE HYDROCHLORIDE (Hospira), DOPAMINE HYDROCHLORIDE (Medical Purchasing Solutions), DOPAMINE HYDROCHLORIDE AND DEXTROSE (Baxter Healthcare Corporation), DOPAMINE HYDROCHLORIDE IN DEXTROSE (Hospira)
  Generic
DOPAMINE HYDROCHLORIDE (HF Acquisition Co LLC), DOPAMINE HYDROCHLORIDE (HF Acquisition Co LLC), DOPAMINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), DOPAMINE HYDROCHLORIDE (Medical Purchasing Solutions)
Formula
C8H11NO2. HCl
Exact mass
189.0557
Mol weight
189.6394
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
Neuropsychiatric agent
 DG01472  Dopamine agonist
Metabolizing enzyme substrate
 DG01592  COMT substrate
 DG02917  MAO substrate
  DG03179  MAOB substrate
Transporter substrate
 DG02854  SLC22A2 substrate
Remark
Therapeutic category: 2119
ATC code: C01CA04
Chemical structure group: DG00213
Product (DG00213): D00633<JP/US>
Efficacy
Cardiotonic, Dopamine receptor agonist
  Disease
Myocardial infarction [DS:H01730]
Comment
Catecholamine derivative
Target
DRD [HSA:1812 1813 1814 1815 1816] [KO:K04144 K04145 K04146 K04147 K05840]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: MAOB [HSA:4129], COMT [HSA:1312]
Transporter: SLC22A2 [HSA:6582]
Interaction
Structure map
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA04 Dopamine
      D00633  Dopamine hydrochloride (JP18/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   211  Cardiotonics
    2119  Others
     D00633  Dopamine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01703  Cardiotonic
   DG01699  Catecholamine cardiotonic
    DG00213  Dopamine
     D00633  Dopamine hydrochloride
 Neuropsychiatric agent
  DG01472  Dopamine agonist
   DG00213  Dopamine
    D00633  Dopamine hydrochloride
 Metabolizing enzyme substrate
  DG01592  COMT substrate
   DG00213  Dopamine
    D00633  Dopamine hydrochloride
  DG02917  MAO substrate
   DG03179  MAOB substrate
    DG00213  Dopamine
     D00633  Dopamine hydrochloride
 Transporter substrate
  DG02854  SLC22A2 substrate
   DG00213  Dopamine
    D00633  Dopamine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD
     D00633  Dopamine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00633  Dopamine hydrochloride
  D00633  Dopamine hydrochloride injection
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00633
 Drug transporters
  D00633
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01703  Cardiotonic
   DG01699  Catecholamine cardiotonic
    DG00213  Dopamine
 Neuropsychiatric agent
  DG01472  Dopamine agonist
   DG00213  Dopamine
 Metabolizing enzyme substrate
  DG01592  COMT substrate
   DG00213  Dopamine
  DG02917  MAO substrate
   DG03179  MAOB substrate
    DG00213  Dopamine
 Transporter substrate
  DG02854  SLC22A2 substrate
   DG00213  Dopamine
Other DBs
CAS: 62-31-7
PubChem: 7847699
ChEBI: 4698
LigandBox: D00633
NIKKAJI: J237.158H
LinkDB
KCF data

ATOM        12
            1   C8y C    28.7000  -14.7000
            2   C8x C    27.5100  -14.0000
            3   C8x C    28.7000  -16.1000
            4   C1b C    29.8900  -14.0000
            5   C8y C    26.3200  -14.7000
            6   C8x C    27.5100  -16.8000
            7   C1b C    31.1500  -14.7000
            8   C8y C    26.3200  -16.1000
            9   O1a O    25.0600  -14.0000
            10  N1a N    32.3400  -14.0000
            11  O1a O    25.0600  -16.8000
            12  X   Cl   32.5500  -16.8000
BOND        11
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     5   9 1
            9     7  10 1
            10    8  11 1
            11    6   8 2

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