| Entry |
|
|---|
| Name |
Granisetron hydrochloride (JAN/USP);
Kytril (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C18H24N4O. HCl
|
|---|
| Exact mass |
348.1717
|
|---|
| Mol weight |
348.8703
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG01762 Antiemetic
Metabolizing enzyme substrate
DG01891 CYP1A1 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 2391 |
| Product (DG00061): | D04370<US> D00677<JP/US> |
|
|---|
| Efficacy |
Anti-emetic, Serotonin 5-HT3 receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP1A1 [HSA: 1543]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07211 | Serotonin receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A04 ANTIEMETICS AND ANTINAUSEANTS
A04A ANTIEMETICS AND ANTINAUSEANTS
A04AA Serotonin (5HT3) antagonists
A04AA02 Granisetron
D00677 Granisetron hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Antiemetics
Emetogenic Therapy Adjuncts
Granisetron
D00677 Granisetron hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
239 Miscellaneous
2391 Antiemetics
D00677 Granisetron hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG00061 Granisetron
D00677 Granisetron hydrochloride
DG01762 Antiemetic
DG00061 Granisetron
D00677 Granisetron hydrochloride
Metabolizing enzyme substrate
DG01891 CYP1A1 substrate
DG00061 Granisetron
D00677 Granisetron hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00061 Granisetron
D00677 Granisetron hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Serotonin
HTR3B
D00677 Granisetron hydrochloride (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00677
Drug groups [BR:br08330]
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG00061 Granisetron
DG01762 Antiemetic
DG00061 Granisetron
Metabolizing enzyme substrate
DG01891 CYP1A1 substrate
DG00061 Granisetron
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00061 Granisetron
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 24
1 X Cl 38.4938 -15.6255
2 C1x C 25.8300 -15.8200
3 C1x C 25.9700 -14.9100
4 C1y C 26.9500 -15.5400
5 C1y C 27.2300 -14.4200
6 N1y N 26.0400 -13.1600
7 C1x C 28.7000 -15.5400
8 C1x C 28.4200 -14.4200
9 C1y C 29.6800 -16.0300
10 N1b N 30.7300 -16.9400
11 C5a C 31.8500 -16.9400
12 C8y C 32.4100 -15.8900
13 O5a O 32.4100 -17.9900
14 C1a C 25.3400 -12.0400
15 C1x C 24.8500 -14.4200
16 C8y C 33.7400 -15.8900
17 C8y C 34.1600 -14.6300
18 N4y N 33.1100 -13.8600
19 N5x N 31.9900 -14.6300
20 C8x C 34.6500 -16.8700
21 C8x C 35.9100 -16.5900
22 C8x C 36.3300 -15.3300
23 C8x C 35.4200 -14.3500
24 C1a C 33.1100 -12.5300
BOND 26
1 2 4 1
2 3 5 1
3 4 6 1
4 4 7 1
5 5 8 1
6 7 9 1
7 9 10 1
8 10 11 1
9 11 12 1
10 11 13 2
11 5 6 1
12 8 9 1
13 6 14 1
14 3 15 1
15 2 15 1
16 12 16 1
17 16 17 1
18 17 18 1
19 18 19 1
20 12 19 2
21 16 20 2
22 20 21 1
23 21 22 2
24 22 23 1
25 17 23 2
26 18 24 1
|
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