| Entry |
|
|---|
| Name |
Dolasetron mesylate (USP);
Anzemet (TN) |
|---|
| Product |
|
|---|
| Formula |
C19H20N2O3. CH4SO3
|
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| Exact mass |
420.1355
|
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| Mol weight |
420.4794
|
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| Structure |
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| Simcomp |
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| Class |
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG01762 Antiemetic
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
|
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| Remark |
| Product (DG00063): | D00725<US> |
|
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| Efficacy |
Anti-emetic, Antimigraine, Serotonin 5-HT3 receptor antagonist |
|---|
| Comment |
Prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy
|
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| Target |
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| Pathway |
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| Metabolism |
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A04 ANTIEMETICS AND ANTINAUSEANTS
A04A ANTIEMETICS AND ANTINAUSEANTS
A04AA Serotonin (5HT3) antagonists
A04AA04 Dolasetron
D00725 Dolasetron mesylate (USP) <US>
Drug groups [BR:br08330]
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG00063 Dolasetron
D00725 Dolasetron mesylate
DG01762 Antiemetic
DG00063 Dolasetron
D00725 Dolasetron mesylate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00063 Dolasetron
D00725 Dolasetron mesylate
DG01633 CYP3A/CYP3A4 substrate
DG00063 Dolasetron
D00725 Dolasetron mesylate
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Serotonin
HTR3
D00725 Dolasetron mesylate (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00725
Drug groups [BR:br08330]
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG00063 Dolasetron
DG01762 Antiemetic
DG00063 Dolasetron
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00063 Dolasetron
DG01633 CYP3A/CYP3A4 substrate
DG00063 Dolasetron
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 29
1 S4a S 24.8049 -14.6438
2 C1a C 23.3948 -14.6321
3 O1d O 26.2036 -14.6438
4 O1d O 24.7932 -13.2394
5 O1d O 24.7932 -16.0425
6 O7a O 14.7328 -15.2219
7 C1y C 13.7087 -14.6075
8 C7a C 16.1665 -15.2219
9 C8y C 16.8492 -14.0613
10 O6a O 16.8492 -16.4508
11 C8y C 18.2147 -13.9931
12 C8y C 18.4877 -12.6277
13 N4x N 17.3271 -11.9450
14 C8x C 16.3030 -12.8325
15 C8x C 19.1022 -14.8806
16 C8x C 20.4676 -14.4709
17 C8x C 20.7407 -13.1739
18 C8x C 19.7166 -12.2180
19 C1y C 11.5924 -13.9931
20 N1y N 12.1385 -11.3988
21 C1x C 10.7731 -14.6075
22 C1x C 12.8212 -13.9931
23 C1y C 12.1385 -12.7642
24 C1x C 10.9097 -10.7161
25 C1y C 9.7490 -12.7642
26 C1x C 10.9097 -13.4469
27 C1x C 13.2991 -13.4469
28 C5x C 9.7490 -11.3988
29 O5x O 8.5201 -10.7161
BOND 32
1 1 2 1
2 1 3 1
3 1 4 2
4 1 5 2
5 7 6 1
6 6 8 1
7 8 9 1
8 8 10 2
9 9 11 1
10 11 12 1
11 12 13 1
12 13 14 1
13 9 14 2
14 11 15 2
15 15 16 1
16 16 17 2
17 17 18 1
18 12 18 2
19 19 20 1
20 19 21 1
21 19 22 1
22 20 23 1
23 20 24 1
24 21 25 1
25 22 7 1
26 23 26 1
27 23 27 1
28 24 28 1
29 28 29 2
30 25 26 1
31 25 28 1
32 7 27 1
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