Entry |
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Name |
Loperamide hydrochloride (JAN/USP); Imodium (TN) |
Product |
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Generic |
LOPERAMIDE HYDROCHLORIDE (A-S Medication Solutions), LOPERAMIDE HYDROCHLORIDE (Advagen Pharma Ltd.,), LOPERAMIDE HYDROCHLORIDE (American Health Packaging), LOPERAMIDE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), LOPERAMIDE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), LOPERAMIDE HYDROCHLORIDE (Aurobindo Pharma Limited), LOPERAMIDE HYDROCHLORIDE (AvPAK), LOPERAMIDE HYDROCHLORIDE (Bionpharma), LOPERAMIDE HYDROCHLORIDE (Bryant Ranch Prepack), LOPERAMIDE HYDROCHLORIDE (Bryant Ranch Prepack), LOPERAMIDE HYDROCHLORIDE (Bryant Ranch Prepack), LOPERAMIDE HYDROCHLORIDE (Bryant Ranch Prepack), LOPERAMIDE HYDROCHLORIDE (Cardinal Health 107), LOPERAMIDE HYDROCHLORIDE (DIRECT RX), LOPERAMIDE HYDROCHLORIDE (Edenbridge Pharmaceuticals LLC.), LOPERAMIDE HYDROCHLORIDE (JUBILANT CADISTA PHARMACEUTICALS), LOPERAMIDE HYDROCHLORIDE (Mylan Pharmaceuticals), LOPERAMIDE HYDROCHLORIDE (NCS HealthCare of KY), LOPERAMIDE HYDROCHLORIDE (NCS HealthCare of KY), LOPERAMIDE HYDROCHLORIDE (NuCare Pharmaceuticals), LOPERAMIDE HYDROCHLORIDE (NuCare Pharmaceuticals), LOPERAMIDE HYDROCHLORIDE (NuCare Pharmaceuticals), LOPERAMIDE HYDROCHLORIDE (PD-Rx Pharmaceuticals), LOPERAMIDE HYDROCHLORIDE (PD-Rx Pharmaceuticals), LOPERAMIDE HYDROCHLORIDE (REMEDYREPACK), LOPERAMIDE HYDROCHLORIDE (REMEDYREPACK), LOPERAMIDE HYDROCHLORIDE (REMEDYREPACK), LOPERAMIDE HYDROCHLORIDE (REMEDYREPACK), LOPERAMIDE HYDROCHLORIDE (Redpharm Drug), LOPERAMIDE HYDROCHLORIDE (Teva Pharmaceuticals USA), LOPERAMIDE HYDROCHLORIDE (Viona Pharmaceuticals), LOPERAMIDE HYDROCHLORIDE (Zydus Lifesciences Limited), LOPERAMIDE HYDROCHLORIDE (allphamed Pharbil Arzneimittel GmbH) |
Formula |
C29H33ClN2O2. HCl
|
Exact mass |
512.1997
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Mol weight |
513.4985
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Structure |
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Simcomp |
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Class |
Neuropsychiatric agent
DG01564 Opioid receptor agonist
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Transporter substrate
DG01665 ABCB1 substrate
|
Remark |
Therapeutic category: | 2319 |
Product (DG00092): | D00729<JP/US> |
|
Efficacy |
Antidiarrheal, Antiperistaltic, Opioid receptor agonist |
Target |
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Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
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Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP2C8 [HSA: 1558]
Transporter: ABCB1 [HSA: 5243]
|
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07D ANTIPROPULSIVES
A07DA Antipropulsives
A07DA03 Loperamide
D00729 Loperamide hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Gastrointestinal Agents
Anti-diarrheal Agents
Loperamide
D00729 Loperamide hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
231 Antidiarrheals, intestinal regulators
2319 others
D00729 Loperamide hydrochloride (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for digestive organs
16 Antidiarrheals
D00729 Loperamide hydrochloride (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Loperamide
D00729 Loperamide hydrochloride (JAN/USP)
Second-class OTC drugs
Inorganic and organic chemicals
Loperamide
D00729 Loperamide hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG00092 Loperamide
D00729 Loperamide hydrochloride
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00092 Loperamide
D00729 Loperamide hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00092 Loperamide
D00729 Loperamide hydrochloride
Transporter substrate
DG01665 ABCB1 substrate
DG00092 Loperamide
D00729 Loperamide hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D00729 Loperamide hydrochloride (JAN/USP) <JP/US>
OPRK1
D00729 Loperamide hydrochloride (JAN/USP) <JP/US>
OPRD1
D00729 Loperamide hydrochloride (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00729
Drug transporters
D00729
Rx-to-OTC switch list in Japan [br08314.html]
D00729
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG00092 Loperamide
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00092 Loperamide
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00092 Loperamide
Transporter substrate
DG01665 ABCB1 substrate
DG00092 Loperamide
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Other DBs |
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LinkDB |
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KCF data |
ATOM 35
1 X Cl 36.9600 -15.4700
2 C8x C 28.0700 -18.6900
3 C8x C 28.0700 -20.0200
4 C8x C 29.2600 -20.7200
5 C8x C 30.4500 -20.0200
6 C8y C 30.4500 -18.6900
7 C8x C 29.2600 -18.0600
8 C8x C 32.7600 -20.0200
9 C8y C 32.7600 -18.6900
10 C1d C 31.5700 -18.0600
11 C8x C 33.9500 -20.7200
12 C8x C 35.0700 -20.0200
13 C8x C 35.0700 -18.6900
14 C8x C 33.9500 -18.0600
15 C5a C 28.3500 -16.3800
16 N1c N 27.2300 -17.0800
17 O5a O 28.3500 -15.0500
18 C1b C 31.5700 -16.6600
19 C1b C 32.8300 -15.9600
20 N1y N 32.8300 -14.5600
21 C1x C 34.0200 -13.8600
22 C1x C 34.0200 -12.4600
23 C1z C 32.8300 -11.7600
24 C1x C 31.5700 -12.4600
25 C1x C 31.5700 -13.8600
26 C1a C 25.9938 -16.4229
27 C1a C 27.2090 -18.4791
28 C8y C 32.8472 -10.3601
29 C8x C 34.0551 -9.6824
30 C8x C 34.0722 -8.2825
31 C8y C 32.8684 -7.5677
32 C8x C 31.6606 -8.2454
33 C8x C 31.6435 -9.6453
34 O1a O 34.0424 -11.0600
35 X Cl 32.8855 -6.1601
BOND 37
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 8 9 1
8 9 10 1
9 6 10 1
10 8 11 2
11 11 12 1
12 12 13 2
13 13 14 1
14 9 14 2
15 10 15 1
16 15 16 1
17 15 17 2
18 10 18 1
19 18 19 1
20 19 20 1
21 20 21 1
22 21 22 1
23 22 23 1
24 23 24 1
25 24 25 1
26 20 25 1
27 16 26 1
28 16 27 1
29 23 28 1
30 28 29 2
31 29 30 1
32 30 31 2
33 31 32 1
34 32 33 2
35 28 33 1
36 23 34 1
37 31 35 1
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