 | | DRUG: Tizanidine hydrochloride | |
| Entry |
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| Name |
Tizanidine hydrochloride (JP18/USP);
Zanaflex (TN) |
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| Product |
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| Generic |
TIZANDINE (DIRECT RX), TIZANDINE (DirectRX), TIZANDINE (Direct_Rx), TIZANDINE (Direct_Rx), TIZANDINE (Direct_Rx), TIZANIDINE (A-S Medication Solutions), TIZANIDINE (A-S Medication Solutions), TIZANIDINE (A-S Medication Solutions), TIZANIDINE (A-S Medication Solutions), TIZANIDINE (A-S Medication Solutions), TIZANIDINE (A-S Medication Solutions), TIZANIDINE (American Health Packaging), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Apotex Corp.), TIZANIDINE (Ascend Laboratories), TIZANIDINE (Asclemed USA), TIZANIDINE (AvKARE), TIZANIDINE (AvPAK), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Cardinal Health 107), TIZANIDINE (Direct_Rx), TIZANIDINE (Dr. Reddy's Laboratories Limited), TIZANIDINE (Major Pharmaceuticals), TIZANIDINE (NCS HealthCare of KY), TIZANIDINE (NorthStar Rx LLC), TIZANIDINE (Northwind Pharmaceuticals), TIZANIDINE (Northwind Pharmaceuticals), TIZANIDINE (NuCare Pharmaceuticals), TIZANIDINE (NuCare Pharmaceuticals), TIZANIDINE (PD-Rx Pharmaceuticals), TIZANIDINE (PD-Rx Pharmaceuticals), TIZANIDINE (PD-Rx Pharmaceuticals), TIZANIDINE (PD-Rx Pharmaceuticals), TIZANIDINE (Preferred Pharmaceuticals), TIZANIDINE (Preferred Pharmaceuticals), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Quality Care Products), TIZANIDINE (REMEDYREPACK), TIZANIDINE (REMEDYREPACK), TIZANIDINE (REMEDYREPACK), TIZANIDINE (REMEDYREPACK), TIZANIDINE (RPK Pharmaceuticals), TIZANIDINE (RPK Pharmaceuticals), TIZANIDINE (St Mary's Medical Park Pharmacy), TIZANIDINE (St. Mary's Medical Park Pharmacy), TIZANIDINE (St. Mary's Medical Park Pharmacy), TIZANIDINE (St. Mary's Medical Park Pharmacy), TIZANIDINE (St. Mary's Medical Park Pharmacy), TIZANIDINE (St. Mary's Medical Park Pharmacy), TIZANIDINE (Sun Pharmaceutical Industries), TIZANIDINE (Unichem Pharmaceuticals (USA)), TIZANIDINE (Viona Pharmaceuticals), TIZANIDINE (Zydus Lifesciences Limited), TIZANIDINE HCL (ADVANCED RX PHARMACY OF TENNESSEE), TIZANIDINE HCL (Advanced Rx Pharmacy of Tennessee), TIZANIDINE HCL (Advanced Rx Pharmacy of Tennessee), TIZANIDINE HCL (Advanced Rx Pharmacy of Tennessee), TIZANIDINE HCL (Advanced Rx Pharmacy of Tennessee), TIZANIDINE HCL (Advanced Rx Pharmacy of Tennessee), TIZANIDINE HYDROCHLORIDE (Actavis Pharma), TIZANIDINE HYDROCHLORIDE (Advagen Pharma Limited), TIZANIDINE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), TIZANIDINE HYDROCHLORIDE (Alembic Pharmaceuticals), TIZANIDINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TIZANIDINE HYDROCHLORIDE (Apotex Corp.), TIZANIDINE HYDROCHLORIDE (Aurobindo Pharma Limited), TIZANIDINE HYDROCHLORIDE (AvKARE), TIZANIDINE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDINE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDINE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDINE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDINE HYDROCHLORIDE (Cadila Pharmaceuticals Limited), TIZANIDINE HYDROCHLORIDE (Ingenus Pharmaceuticals), TIZANIDINE HYDROCHLORIDE (Modavar Pharmaceuticals LLC), TIZANIDINE HYDROCHLORIDE (Nivagen Pharmaceuticals), TIZANIDINE HYDROCHLORIDE (Preferred Pharmaceuticals), TIZANIDINE HYDROCHLORIDE (Quality Care Products LLC), TIZANIDINE HYDROCHLORIDE (Quality Care Products), TIZANIDINE HYDROCHLORIDE (Quality Care Products), TIZANIDINE HYDROCHLORIDE (TIZANIDINE HYDROCHLORIDE), TIZANIDINE HYDROCHLORIDE (Zydus Lifesciences Limited), TIZANIDINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), TIZANIDINE HYDROCHLORIDE (medsource pharmaceuticals), TIZANIDNE HYDROCHLORIDE (Ascend Laboratories), TIZANIDNE HYDROCHLORIDE (Asclemed USA), TIZANIDNE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDNE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDNE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDNE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDNE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDNE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDNE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDNE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDNE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDNE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDNE HYDROCHLORIDE (Preferred Pharmaceuticals) |
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| Formula |
C9H8ClN5S. HCl
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| Exact mass |
288.9956
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| Mol weight |
290.1723
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
Musculo-skeletal system agent
DG02029 Muscle relaxant
DG01974 Centrally acting muscle relaxant
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
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| Remark |
| Therapeutic category: | 1249 |
| Product (DG00773): | D00776<JP/US> |
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| Efficacy |
Antispasmodic, Muscle relaxant, alpha2-Adrenergic receptor agonist |
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| Comment |
Imidazoline derivative
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP1A2 [HSA: 1544]
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M03 MUSCLE RELAXANTS
M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
M03BX Other centrally acting agents
M03BX02 Tizanidine
D00776 Tizanidine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antispasticity Agents
Tizanidine
D00776 Tizanidine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
12 Agents affecting peripheral nervous system
124 Antispasmodics
1249 Others
D00776 Tizanidine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
DG00773 Tizanidine
D00776 Tizanidine hydrochloride
Musculo-skeletal system agent
DG02029 Muscle relaxant
DG01974 Centrally acting muscle relaxant
DG00773 Tizanidine
D00776 Tizanidine hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00773 Tizanidine
D00776 Tizanidine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA2
D00776 Tizanidine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00776 Tizanidine hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00776
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
DG00773 Tizanidine
Musculo-skeletal system agent
DG02029 Muscle relaxant
DG01974 Centrally acting muscle relaxant
DG00773 Tizanidine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00773 Tizanidine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 17
1 C8y C 29.0260 -18.0837
2 C8y C 29.0260 -16.6827
3 C8y C 27.8120 -18.7958
4 N5x N 30.0708 -19.0235
5 N1b N 30.2343 -15.9882
6 C8y C 27.8120 -15.9823
7 C8x C 26.5921 -18.0837
8 N5x N 28.1155 -20.1617
9 S2x S 29.5105 -20.3018
10 C2y C 31.4426 -16.6944
11 C8x C 26.5921 -16.6827
12 X Cl 27.8003 -14.5816
13 N1x N 32.7500 -16.2424
14 N2x N 31.4535 -18.0910
15 C1x C 33.5919 -17.3543
16 C1x C 32.7903 -18.4961
17 X Cl 36.7067 -17.3950
BOND 18
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 2
6 3 7 1
7 3 8 2
8 4 9 1
9 5 10 1
10 6 11 1
11 6 12 1
12 10 13 1
13 10 14 2
14 13 15 1
15 14 16 1
16 7 11 2
17 8 9 1
18 15 16 1
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