| Entry |
|
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| Name |
Bicalutamide (JP18/USP/INN);
Casodex (TN) |
|---|
| Product |
|
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| Generic |
|
|---|
| Formula |
C18H14F4N2O4S
|
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| Exact mass |
430.061
|
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| Mol weight |
430.3734
|
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| Structure |
|
|---|
| Simcomp |
|
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| Class |
Antineoplastic
DG01591 Androgen receptor antagonist
DG01624 Flutamide-type antiandrogen
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
|
|---|
| Remark |
| Therapeutic category: | 4291 |
|
|---|
| Efficacy |
Antineoplastic, Androgen receptor antagonist |
|---|
| Disease |
|
|---|
| Target |
|
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| Pathway |
|
|---|
| Network |
|
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| Interaction |
CYP inhibition: CYP3A4 [HSA: 1576]
|
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| Structure map |
| map07226 | Progesterone, androgen and estrogen receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L02 ENDOCRINE THERAPY
L02B HORMONE ANTAGONISTS AND RELATED AGENTS
L02BB Anti-androgens
L02BB03 Bicalutamide
D00961 Bicalutamide (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
Antiandrogens
Bicalutamide
D00961 Bicalutamide (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
429 Miscellaneous
4291 Other Antitumors
D00961 Bicalutamide (JP18/USP/INN)
Drug groups [BR:br08330]
Antineoplastic
DG01591 Androgen receptor antagonist
DG01624 Flutamide-type antiandrogen
D00961 Bicalutamide
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
D00961 Bicalutamide
Drug classes [BR:br08332]
Antineoplastic
DG01591 Androgen receptor antagonist
D00961 Bicalutamide
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C4 (AR)
D00961 Bicalutamide (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00961 Bicalutamide
D00961 Bicalutamide tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00961
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 29
1 C8y C 41.7900 -19.3200
2 C8y C 41.7900 -20.7200
3 C8x C 40.5300 -18.6200
4 C1d C 42.9800 -18.6200
5 C8x C 40.5300 -21.4200
6 C3b C 42.9800 -21.4200
7 C8y C 39.3400 -19.3200
8 X F 44.1700 -17.9200
9 X F 42.2800 -17.4300
10 X F 43.6800 -19.8100
11 C8x C 39.3400 -20.7200
12 N3a N 44.1700 -22.1200
13 N1b N 38.1500 -18.6200
14 C5a C 36.9600 -19.3200
15 C1d C 35.7000 -18.6200
16 O5a O 36.9600 -20.7200
17 C1b C 34.5100 -19.3200
18 C1a C 35.7000 -17.2200
19 S4a S 33.3200 -18.6200
20 C8y C 32.0600 -19.3200
21 O3c O 32.3400 -17.6400
22 O3c O 34.2300 -17.5700
23 O1a O 35.7000 -20.0200
24 C8x C 32.0600 -20.7200
25 C8x C 30.8700 -21.4200
26 C8y C 29.6800 -20.7200
27 C8x C 29.6800 -19.3200
28 C8x C 30.8700 -18.6200
29 X F 28.4200 -21.4200
BOND 30
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 4 8 1
8 4 9 1
9 4 10 1
10 5 11 1
11 6 12 3
12 7 13 1
13 13 14 1
14 14 15 1
15 14 16 2
16 15 17 1
17 15 18 1 #Down
18 17 19 1
19 19 20 1
20 19 21 2
21 19 22 2
22 7 11 2
23 15 23 1 #Up
24 20 24 2
25 24 25 1
26 25 26 2
27 26 27 1
28 27 28 2
29 20 28 1
30 26 29 1
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