| Entry |
|
|---|
| Name |
Propiverine hydrochloride (JP18);
Bup-4 (TN);
Mictonorm (TN) |
|---|
| Formula |
C23H29NO3. HCl
|
|---|
| Exact mass |
403.1914
|
|---|
| Mol weight |
403.9422
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 2590 |
| Product (DG00479): | D01007<JP> |
|
|---|
| Efficacy |
Antipollakisuria, Overactive bladder agent, Muscarinic acetylcholine receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07220 | Cholinergic and anticholinergic drugs |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G04 UROLOGICALS
G04B UROLOGICALS
G04BD Drugs for urinary frequency and incontinence
G04BD06 Propiverine
D01007 Propiverine hydrochloride (JP18) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
25 Urogenital and anal organ agents
259 Miscellaneous
2590 Miscellaneous
D01007 Propiverine hydrochloride (JP18)
Risk category of Japanese OTC drugs [BR:br08312]
Drugs requiring guidance
New approved switch OTC drugs
Propiverine hydrochloride
D01007 Propiverine hydrochloride (JP18)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
DG00479 Propiverine
D01007 Propiverine hydrochloride
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00479 Propiverine
D01007 Propiverine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM
D01007 Propiverine hydrochloride (JP18) <JP>
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D01007 Propiverine hydrochloride (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01007 Propiverine hydrochloride
D01007 Propiverine hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01007
Rx-to-OTC switch list in Japan [br08314.html]
D01007
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
DG00479 Propiverine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00479 Propiverine
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 28
1 X Cl 31.6971 -21.2255
2 C1x C 19.9430 -20.7678
3 N1y N 19.9430 -22.1663
4 C1x C 21.1541 -22.8656
5 C1x C 22.3654 -22.1663
6 C1y C 22.3654 -20.7678
7 C1x C 21.1541 -20.0686
8 O7a O 23.6015 -20.0686
9 C7a C 24.8128 -20.7678
10 C1d C 26.0239 -20.0686
11 C8y C 27.2350 -20.7678
12 C8x C 28.4462 -20.0686
13 C8x C 29.6573 -20.7678
14 C8y C 26.0239 -18.6701
15 C8x C 27.2371 -17.9696
16 C8x C 27.2371 -16.5711
17 C8x C 26.0259 -15.8718
18 C8x C 24.8128 -16.5723
19 C8x C 24.8128 -17.9708
20 C8x C 27.2350 -22.1663
21 C8x C 28.4462 -22.8656
22 C8x C 29.6573 -22.1663
23 O2a O 27.2350 -19.3693
24 C1b C 28.4462 -18.6701
25 C1b C 29.6780 -19.3815
26 C1a C 30.8829 -18.6860
27 O6a O 24.8128 -22.1661
28 C1a C 18.7319 -22.8656
BOND 29
1 2 3 1
2 3 4 1
3 4 5 1
4 5 6 1
5 6 7 1
6 2 7 1
7 6 8 1
8 8 9 1
9 9 10 1
10 10 11 1
11 11 12 1
12 12 13 2
13 10 14 1
14 14 15 1
15 15 16 2
16 16 17 1
17 17 18 2
18 18 19 1
19 14 19 2
20 11 20 2
21 20 21 1
22 21 22 2
23 22 13 1
24 10 23 1
25 23 24 1
26 24 25 1
27 25 26 1
28 9 27 2
29 3 28 1
|
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