| Entry |
|
|---|
| Name |
Promethazine teoclate (JAN/INN);
Avomine (TN) |
|---|
| Formula |
C17H20N2S. C7H7ClN4O2
|
|---|
| Exact mass |
498.1605
|
|---|
| Mol weight |
499.0282
|
|---|
| Structure |
|
|---|
| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Product (DG00385): | D00480<JP/US> D03290<JP> D08768<JP> |
|
|---|
| Efficacy |
Antiallergic, H1 receptor antagonist |
|---|
| Comment |
Phenothiazine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07029 | Antipsychotics - phenothiazines |
| map07212 | Histamine H1 receptor antagonists |
| map07213 | Dopamine receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04AA Antihistamines for topical use
D04AA10 Promethazine
D01242 Promethazine teoclate (JAN/INN)
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AD Phenothiazine derivatives
R06AD02 Promethazine
D01242 Promethazine teoclate (JAN/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for nervous and sensory systems
06 Antivertigo drugs (incl. motion/morning sickness remedies)
D01242 Promethazine teoclate (JAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Promethazine
D01242 Promethazine teoclate (JAN/INN)
Second-class OTC drugs
Inorganic and organic chemicals
Promethazine
D01242 Promethazine teoclate (JAN/INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00385 Promethazine
D01242 Promethazine teoclate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00385 Promethazine
D01242 Promethazine teoclate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D01242 Promethazine teoclate (JAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01242
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00385 Promethazine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00385 Promethazine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 34
1 C8y C 30.2443 -17.6964
2 C8y C 30.2506 -19.0899
3 N5x N 28.9273 -19.5264
4 C8y C 28.1034 -18.4026
5 N4x N 28.9172 -17.2718
6 C8y C 32.6628 -19.0943
7 N4y N 31.4535 -19.7945
8 C8y C 31.4501 -16.9997
9 N4y N 32.6611 -17.6969
10 C1a C 33.8790 -16.9939
11 O5x O 31.4605 -15.5937
12 O5x O 33.8790 -19.7875
13 C1a C 31.4605 -21.1947
14 X Cl 26.7081 -18.4013
15 C8y C 21.7358 -19.8545
16 C8y C 21.7987 -21.2547
17 C8x C 22.9378 -21.9610
18 C8x C 24.2240 -21.2670
19 C8x C 24.2309 -19.8667
20 C8x C 22.9520 -19.1604
21 C8y C 19.3172 -19.8474
22 C8y C 19.3100 -21.2476
23 S2x S 20.5191 -21.9539
24 N1y N 20.5334 -19.1533
25 C8x C 16.8986 -19.8474
26 C8x C 16.8986 -21.2476
27 C8x C 18.1141 -21.9477
28 C8x C 18.1141 -19.1473
29 C1b C 20.5193 -17.7470
30 C1c C 21.7287 -17.0398
31 C1a C 22.9379 -17.7398
32 N1c N 21.7217 -15.6395
33 C1a C 22.9310 -14.9324
34 C1a C 20.5053 -14.9394
BOND 37
1 7 2 1
2 1 8 1
3 8 9 1
4 9 6 1
5 3 4 2
6 9 10 1
7 4 5 1
8 8 11 2
9 5 1 1
10 6 12 2
11 7 13 1
12 4 14 1
13 1 2 2
14 2 3 1
15 6 7 1
16 15 16 2
17 16 17 1
18 17 18 2
19 18 19 1
20 19 20 2
21 20 15 1
22 21 22 2
23 22 23 1
24 23 16 1
25 15 24 1
26 24 21 1
27 25 26 1
28 26 27 2
29 27 22 1
30 21 28 1
31 28 25 2
32 24 29 1
33 29 30 1
34 30 31 1
35 30 32 1
36 32 33 1
37 32 34 1
|
|---|
