Entry |
|
Name |
Mequitazine (JP18/INN); Kitazemin (TN) |
Formula |
C20H22N2S
|
Exact mass |
322.1504
|
Mol weight |
322.4671
|
Structure |
|
Simcomp |
|
Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Dermatological agent
DG03243 Atopic dermatitis agent
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
Remark |
Therapeutic category: | 4413 |
|
Efficacy |
Antiallergic, Antiasthmatic, H1 receptor antagonist |
Comment |
Phenothiazine derivative
|
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
Interaction |
|
Structure map |
map07212 | Histamine H1 receptor antagonists |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AD Phenothiazine derivatives
R06AD07 Mequitazine
D01324 Mequitazine (JP18/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
44 Allergic agents
441 Antihistamines
4413 Phenothiazines
D01324 Mequitazine (JP18/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for nervous and sensory systems
01 Cold remedy (oral use)
D01324 Mequitazine (JP18/INN)
Allergic agents
52 Antihistamine based drugs
D01324 Mequitazine (JP18/INN)
Agents for otolaryngologic use
69 Oral medicine for nasal inflammation
D01324 Mequitazine (JP18/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Mequitazine
D01324 Mequitazine (JP18/INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
D01324 Mequitazine
Dermatological agent
DG03243 Atopic dermatitis agent
D01324 Mequitazine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
D01324 Mequitazine
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D01324 Mequitazine
Dermatological agent
DG03243 Atopic dermatitis agent
D01324 Mequitazine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D01324 Mequitazine (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01324 Mequitazine
D01324 Mequitazine tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01324
Rx-to-OTC switch list in Japan [br08314.html]
D01324
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 23
1 C1x C 23.4130 -15.6918
2 N1y N 24.8526 -14.8141
3 C1y C 22.6816 -14.6444
4 C1x C 24.8526 -13.5735
5 C1x C 26.3564 -15.6216
6 C1y C 24.0978 -13.8077
7 C1x C 24.1035 -12.8187
8 C1x C 25.6602 -14.5097
9 C8x C 17.8213 -17.4339
10 C8x C 17.8213 -18.8339
11 C8x C 19.0367 -19.5339
12 C8x C 19.0367 -16.7339
13 C8y C 20.2449 -17.4339
14 C8y C 20.2388 -18.8339
15 S2x S 21.4483 -19.5392
16 N1y N 21.4603 -16.7392
17 C8y C 22.6698 -17.4443
18 C8y C 22.6570 -18.8407
19 C8x C 23.8600 -19.5497
20 C8x C 25.0756 -18.8626
21 C8x C 25.0883 -17.4662
22 C8x C 23.8853 -16.7572
23 C1b C 21.4663 -15.3392
BOND 27
1 10 11 2
2 11 14 1
3 13 12 1
4 12 9 2
5 2 5 1
6 3 6 1
7 4 7 1
8 5 8 1
9 13 14 2
10 14 15 1
11 15 18 1
12 17 16 1
13 16 13 1
14 6 7 1
15 6 8 1
16 1 2 1
17 1 3 1
18 2 4 1
19 17 18 2
20 18 19 1
21 19 20 2
22 20 21 1
23 21 22 2
24 22 17 1
25 9 10 1
26 16 23 1
27 23 3 1
|