| Entry |
|
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| Name |
Aprindine hydrochloride (JP18/USAN);
Aspenon (TN) |
|---|
| Formula |
C22H30N2. HCl
|
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| Exact mass |
358.2176
|
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| Mol weight |
358.9479
|
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| Structure |
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01651 Class Ib antiarrhythmic agent
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
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| Remark |
| Therapeutic category: | 2129 |
| Product (DG00199): | D01326<JP> |
|
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| Efficacy |
Antiarrhythmic, Sodium channel blocker |
|---|
| Target |
|
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| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
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| Interaction |
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01B ANTIARRHYTHMICS, CLASS I AND III
C01BB Antiarrhythmics, class Ib
C01BB04 Aprindine
D01326 Aprindine hydrochloride (JP18/USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2129 Others
D01326 Aprindine hydrochloride (JP18/USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01651 Class Ib antiarrhythmic agent
DG00199 Aprindine
D01326 Aprindine hydrochloride
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00199 Aprindine
D01326 Aprindine hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG01653 Antiarrhythmics
D01326 Aprindine hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D01326 Aprindine hydrochloride (JP18/USAN) <JP>
SCN2A
D01326 Aprindine hydrochloride (JP18/USAN) <JP>
SCN3A
D01326 Aprindine hydrochloride (JP18/USAN) <JP>
SCN4A
D01326 Aprindine hydrochloride (JP18/USAN) <JP>
SCN5A
D01326 Aprindine hydrochloride (JP18/USAN) <JP>
SCN8A
D01326 Aprindine hydrochloride (JP18/USAN) <JP>
SCN9A
D01326 Aprindine hydrochloride (JP18/USAN) <JP>
SCN10A
D01326 Aprindine hydrochloride (JP18/USAN) <JP>
SCN11A
D01326 Aprindine hydrochloride (JP18/USAN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01326 Aprindine hydrochloride
D01326 Aprindine hydrochloride capsules
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01326
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01651 Class Ib antiarrhythmic agent
DG00199 Aprindine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00199 Aprindine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 25
1 X Cl 32.7915 -19.2578
2 N1c N 26.5338 -17.9795
3 C1b C 26.5338 -16.5753
4 C1b C 27.7273 -15.8732
5 C1b C 28.9208 -16.5753
6 N1c N 30.1845 -15.8732
7 C1b C 31.3780 -16.5753
8 C1a C 32.5715 -15.8732
9 C1b C 30.1845 -14.4692
10 C1a C 31.3780 -13.7671
11 C8y C 27.7273 -18.6815
12 C8x C 27.7273 -20.0856
13 C8x C 28.9910 -20.7877
14 C8x C 30.1845 -20.0856
15 C8x C 30.1845 -18.6815
16 C8x C 28.9208 -17.9795
17 C1y C 25.3541 -18.6537
18 C1x C 25.3481 -20.0476
19 C1x C 24.0304 -18.2171
20 C8y C 23.2061 -19.3413
21 C8y C 24.0205 -20.4726
22 C8x C 21.9150 -19.3243
23 C8x C 21.2284 -20.6165
24 C8x C 21.9395 -21.7455
25 C8x C 23.3412 -21.7991
BOND 26
1 3 4 1
2 7 8 1
3 11 12 2
4 12 13 1
5 13 14 2
6 14 15 1
7 15 16 2
8 16 11 1
9 6 9 1
10 4 5 1
11 9 10 1
12 2 3 1
13 2 11 1
14 5 6 1
15 6 7 1
16 2 17 1
17 17 18 1
18 17 19 1
19 19 20 1
20 20 21 1
21 18 21 1
22 20 22 2
23 22 23 1
24 23 24 2
25 24 25 1
26 21 25 2
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