| Entry |
|
|---|
| Name |
Manidipine hydrochloride (JP18);
Manidipine dihydrochloride;
Calslot (TN) |
|---|
| Formula |
C35H38N4O6. 2HCl
|
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| Exact mass |
682.2325
|
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| Mol weight |
683.6213
|
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 2149 |
| Product (DG00324): | D01553<JP> |
|
|---|
| Efficacy |
Antihypertensive, Vasodilator, Calcium channel blocker |
|---|
| Comment |
Dihydropyridine derivative
|
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| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA11 Manidipine
D01553 Manidipine hydrochloride (JP18) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D01553 Manidipine hydrochloride (JP18)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00324 Manidipine
D01553 Manidipine hydrochloride
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG00324 Manidipine
D01553 Manidipine hydrochloride
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00324 Manidipine
D01553 Manidipine hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG01928 Dihydropyridine calcium channel blocker
D01553 Manidipine hydrochloride
DG03231 Antihypertensive
D01553 Manidipine hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D01553 Manidipine hydrochloride (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01553 Manidipine hydrochloride
D01553 Manidipine hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01553
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00324 Manidipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG00324 Manidipine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00324 Manidipine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 47
1 C8x C 24.4276 -18.8971
2 C8x C 24.4276 -17.4973
3 C8y C 25.6874 -16.7974
4 C8x C 26.8772 -17.4973
5 C8y C 26.8772 -18.8971
6 C8x C 25.6874 -19.5970
7 C1y C 25.6874 -15.3976
8 C2y C 24.4276 -14.6978
9 C2y C 24.4276 -13.2980
10 N1x N 25.6874 -12.5981
11 C2y C 26.8772 -13.2980
12 C2y C 26.8772 -14.6978
13 C7a C 28.0670 -15.3976
14 O7a O 29.3268 -14.6978
15 C1b C 30.5166 -15.3976
16 C1b C 31.7065 -14.6978
17 N1y N 32.9662 -15.3976
18 C1x C 34.1561 -14.6978
19 C1x C 35.3459 -15.3976
20 N1y N 35.3459 -16.7974
21 C1x C 34.1561 -17.4973
22 C1x C 32.9662 -16.7974
23 O6a O 28.0670 -16.7974
24 C1c C 36.6057 -17.4973
25 C8y C 37.7955 -16.7974
26 C8y C 36.6057 -18.8971
27 C8x C 37.7955 -19.5970
28 C8x C 37.7955 -20.9967
29 C8x C 36.5357 -21.6966
30 C8x C 35.3459 -20.9967
31 C8x C 35.3459 -19.5970
32 C8x C 37.7955 -15.3976
33 C8x C 38.9853 -14.6978
34 C8x C 40.1751 -15.3976
35 C8x C 40.1751 -16.7974
36 C8x C 38.9853 -17.4973
37 C1a C 28.0670 -12.5981
38 C1a C 23.2378 -12.5981
39 C7a C 23.2378 -15.3976
40 O6a O 23.2378 -16.7974
41 O7a O 22.0480 -14.6978
42 C1a C 20.7882 -15.3976
43 N2b N 28.0670 -19.5970 #+
44 O3a O 29.3268 -18.8971
45 O3a O 28.0670 -20.9967 #-
46 X Cl 43.3945 -17.3573
47 X Cl 43.3945 -17.3573
BOND 49
1 21 22 1
2 22 17 1
3 7 8 1
4 13 23 2
5 8 9 2
6 20 24 1
7 9 10 1
8 24 25 1
9 10 11 1
10 24 26 1
11 11 12 2
12 12 7 1
13 4 5 1
14 12 13 1
15 5 6 2
16 26 27 2
17 27 28 1
18 28 29 2
19 29 30 1
20 30 31 2
21 31 26 1
22 13 14 1
23 6 1 1
24 14 15 1
25 15 16 1
26 25 32 2
27 32 33 1
28 33 34 2
29 34 35 1
30 35 36 2
31 36 25 1
32 3 7 1
33 11 37 1
34 16 17 1
35 9 38 1
36 8 39 1
37 39 40 2
38 1 2 2
39 39 41 1
40 2 3 1
41 41 42 1
42 3 4 2
43 5 43 1
44 17 18 1
45 43 44 2
46 18 19 1
47 43 45 1
48 19 20 1
49 20 21 1
BRACKET 1 41.9300 -18.1300 41.9300 -16.5900
1 44.1700 -16.5900 44.1700 -18.1300
1 2
ORIGINAL 1 46
REPEAT 1 47
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