| Entry |
|
|---|
| Name |
Indometacin farnesil (JAN);
Infree (TN) |
|---|
| Formula |
C34H40ClNO4
|
|---|
| Exact mass |
561.2646
|
|---|
| Mol weight |
562.1387
|
|---|
| Structure |
|
|---|
| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01899 Anti-inflammatory drug, indoleacetic acid derivatives
|
|---|
| Remark |
| Therapeutic category: | 1145 |
| Product (DG00241): | D00141<JP/US> D01565<JP> D02110<JP/US> |
|
|---|
| Efficacy |
Analgesic, Anti-inflammatory, COX inhibitor |
|---|
| Comment |
Indole acetic acid derivative
Active form of prodrug: Indometacin [DR: D00141]
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01E OTHER CARDIAC PREPARATIONS
C01EB Other cardiac preparations
C01EB03 Indometacin
D01565 Indometacin farnesil (JAN) <JP>
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AB Acetic acid derivatives and related substances
M01AB01 Indometacin
D01565 Indometacin farnesil (JAN) <JP>
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA23 Indometacin
D01565 Indometacin farnesil (JAN) <JP>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BC Antiinflammatory agents, non-steroids
S01BC01 Indometacin
D01565 Indometacin farnesil (JAN) <JP>
USP drug classification [BR:br08302]
Analgesics
Nonsteroidal Anti-inflammatory Drugs
Indomethacin
D01565 Indometacin farnesil (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
114 Antipyretics and analgesics, anti-inflammatory agents
1145 Indomethacins
D01565 Indometacin farnesil (JAN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Indometacin
D01565 Indometacin farnesil (JAN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01899 Anti-inflammatory drug, indoleacetic acid derivatives
DG00241 Indometacin
D01565 Indometacin farnesil
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D01565 Indometacin farnesil
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D01565 Indometacin farnesil (JAN) <JP>
PTGS2 (COX2)
D01565 Indometacin farnesil (JAN) <JP>
Prodrugs [br08324.html]
D01565
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01899 Anti-inflammatory drug, indoleacetic acid derivatives
DG00241 Indometacin
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 40
1 C8y C 16.2574 -17.8893
2 C8y C 16.2492 -19.3361
3 C1a C 17.5115 -20.0708
4 C7a C 18.7741 -17.9038
5 C1b C 17.5200 -17.1691
6 C8y C 13.9595 -19.2253
7 C8y C 13.9595 -17.8952
8 N4y N 15.1153 -19.8944
9 C8x C 12.7964 -19.8806
10 C8x C 12.7964 -17.2188
11 C5a C 15.1109 -21.2096
12 C8x C 11.6544 -19.2253
13 C8y C 11.6544 -17.8952
14 C8y C 14.2929 -21.6415
15 O2a O 10.5135 -17.2397
16 C8x C 13.1448 -20.9522
17 C8x C 14.2567 -22.9696
18 C1a C 9.3716 -17.9090
19 C8x C 11.9779 -21.5907
20 C8x C 13.1052 -23.6075
21 C8y C 11.9640 -22.9158
22 X Cl 10.8157 -23.5599
23 O7a O 20.0364 -17.1837
24 O6a O 18.7741 -19.3505
25 C1b C 21.2913 -17.9168
26 C2b C 22.5538 -17.1966
27 C2c C 23.8087 -17.9297
28 C1b C 25.0712 -17.2094
29 C1a C 23.8013 -19.3831
30 C1b C 26.3262 -17.9427
31 C2b C 27.5885 -17.2224
32 C2c C 28.8436 -17.9556
33 C1b C 30.1059 -17.2353
34 C1a C 28.8362 -19.4089
35 C1b C 31.3608 -17.9686
36 C2b C 32.6233 -17.2483
37 C2c C 33.8783 -17.9815
38 C1a C 35.1408 -17.2612
39 C1a C 33.8708 -19.4348
40 O5a O 16.3155 -21.9386
BOND 42
1 14 16 2
2 14 17 1
3 15 18 1
4 16 19 1
5 17 20 2
6 19 21 2
7 21 22 1
8 12 13 1
9 20 21 1
10 4 5 1
11 4 23 1
12 5 1 1
13 4 24 2
14 23 25 1
15 1 2 2
16 25 26 1
17 2 3 1
18 26 27 2
19 6 7 2
20 27 28 1
21 6 8 1
22 27 29 1
23 6 9 1
24 28 30 1
25 7 1 1
26 30 31 1
27 7 10 1
28 31 32 2
29 8 2 1
30 32 33 1
31 8 11 1
32 32 34 1
33 9 12 2
34 33 35 1
35 10 13 2
36 35 36 1
37 11 14 1
38 36 37 2
39 37 38 1
40 13 15 1
41 37 39 1
42 11 40 2
|
|---|
