| Entry |
|
|---|
| Name |
Sarpogrelate hydrochloride (JP18);
Anplag (TN) |
|---|
| Formula |
C24H31NO6. HCl
|
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| Exact mass |
465.1918
|
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| Mol weight |
465.967
|
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| Structure |
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| Simcomp |
|
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| Class |
|
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| Remark |
| Therapeutic category: | 3399 |
| Product (DG01333): | D01624<JP> |
|
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| Efficacy |
Anticoagulant, Platelet aggregation inhibitor, Serotonin 5-HT2 receptor antagonist |
|---|
| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP2B6 [HSA: 1555], CYP2C9 [HSA: 1559], CYP2C19 [HSA: 1557], CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
|
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| Interaction |
|
|---|
| Structure map |
| map07211 | Serotonin receptor agonists/antagonists |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
3 Agents affecting metabolism
33 Blood and body fluid agents
339 Miscellaneous
3399 Others
D01624 Sarpogrelate hydrochloride (JP18)
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
DG01333 Sarpogrelate
D01624 Sarpogrelate hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01333 Sarpogrelate
D01624 Sarpogrelate hydrochloride
DG02919 CYP2B6 substrate
DG01333 Sarpogrelate
D01624 Sarpogrelate hydrochloride
DG01642 CYP2C9 substrate
DG01333 Sarpogrelate
D01624 Sarpogrelate hydrochloride
DG01639 CYP2C19 substrate
DG01333 Sarpogrelate
D01624 Sarpogrelate hydrochloride
DG01644 CYP2D6 substrate
DG01333 Sarpogrelate
D01624 Sarpogrelate hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01333 Sarpogrelate
D01624 Sarpogrelate hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Serotonin
HTR2A
D01624 Sarpogrelate hydrochloride (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01624 Sarpogrelate hydrochloride
D01624 Sarpogrelate hydrochloride tablets
D01624 Sarpogrelate hydrochloride fine granules
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01624
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
DG01333 Sarpogrelate
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01333 Sarpogrelate
DG02919 CYP2B6 substrate
DG01333 Sarpogrelate
DG01642 CYP2C9 substrate
DG01333 Sarpogrelate
DG01639 CYP2C19 substrate
DG01333 Sarpogrelate
DG01644 CYP2D6 substrate
DG01333 Sarpogrelate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01333 Sarpogrelate
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 32
1 C8y C 20.8521 -17.4758
2 O2a O 22.0660 -16.7720
3 C8x C 19.6381 -16.7780
4 C8y C 20.8521 -18.8773
5 C1b C 23.2740 -17.4758
6 C8x C 18.4301 -17.4758
7 C8x C 19.6441 -19.5753
8 C1c C 24.4879 -16.7720
9 C8x C 18.4301 -18.8773
10 O7a O 25.7019 -17.4758
11 C1b C 24.4879 -15.3705
12 C7a C 26.9100 -16.7720
13 C1b C 28.1240 -17.4758
14 C1b C 29.3380 -16.7720
15 C6a C 30.5460 -17.4758
16 O6a O 31.7599 -16.7720
17 O6a O 26.9087 -15.3689
18 O6a O 30.5446 -18.8789
19 C1b C 22.0614 -19.5687
20 C1b C 23.2732 -18.8671
21 C8y C 24.4848 -19.5615
22 C8x C 24.4893 -20.9581
23 C8x C 25.7010 -21.6527
24 C8x C 26.9083 -20.9505
25 C8y C 26.9039 -19.5539
26 C8x C 25.6922 -18.8595
27 O2a O 28.1167 -18.8484
28 C1a C 29.3341 -19.5460
29 N1c N 23.2730 -14.6689
30 C1a C 23.2730 -13.2659
31 C1a C 22.0579 -15.3705
32 X Cl 33.1159 -19.4624
BOND 32
1 15 16 1
2 7 9 1
3 12 17 2
4 15 18 2
5 1 2 1
6 4 19 1
7 1 3 2
8 19 20 1
9 1 4 1
10 20 21 1
11 2 5 1
12 3 6 1
13 4 7 2
14 5 8 1
15 6 9 2
16 21 22 2
17 22 23 1
18 23 24 2
19 24 25 1
20 25 26 2
21 26 21 1
22 8 10 1
23 25 27 1
24 8 11 1
25 27 28 1
26 10 12 1
27 11 29 1
28 12 13 1
29 29 30 1
30 13 14 1
31 29 31 1
32 14 15 1
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