| Entry |
|
|---|
| Name |
Proxyphylline (JAN/INN);
Monophyllin (TN) |
|---|
| Formula |
C10H14N4O3
|
|---|
| Exact mass |
238.1066
|
|---|
| Mol weight |
238.2432
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Respiratory system agent
DG01616 Xanthine derivative
DG01609 Xanthine-type bronchodilator
|
|---|
| Remark |
| Therapeutic category: | 2115 |
|
|---|
| Efficacy |
Bronchodilator, Cardiotonic, Phosphodiesterase inhibitor |
|---|
| Comment |
Xanthine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03D OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03DA Xanthines
R03DA03 Proxyphylline
D01771 Proxyphylline (JAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
211 Cardiotonics
2115 Caffeines
D01771 Proxyphylline (JAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Proxyphylline
D01771 Proxyphylline (JAN/INN)
Drug groups [BR:br08330]
Respiratory system agent
DG01616 Xanthine derivative
DG01609 Xanthine-type bronchodilator
D01771 Proxyphylline
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adenosine
ADORA1
D01771 Proxyphylline (JAN/INN) <JP>
ADORA2
D01771 Proxyphylline (JAN/INN) <JP>
Enzymes
Hydrolases (EC3)
Phosphodiesterases
PDE
D01771 Proxyphylline (JAN/INN) <JP>
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 17
1 N4y N 31.3993 -16.0548
2 C8y C 32.7383 -16.4757
3 C8y C 32.7500 -17.8791
4 C8y C 33.9664 -15.7800
5 N4y N 33.9664 -18.5809
6 N5x N 31.4167 -18.3294
7 N4y N 35.1709 -16.4816
8 O5x O 33.9664 -14.3824
9 C8x C 30.5805 -17.2008
10 C8y C 35.1709 -17.8791
11 C1a C 33.9664 -19.9785
12 C1a C 36.3814 -15.7857
13 O5x O 36.3814 -18.5809
14 C1b C 31.3993 -14.6548
15 C1c C 30.1998 -13.9618
16 C1a C 28.9792 -14.6662
17 O1a O 30.2008 -12.5303
BOND 18
1 2 3 2
2 2 4 1
3 2 1 1
4 3 5 1
5 3 6 1
6 4 7 1
7 4 8 2
8 1 9 1
9 5 10 1
10 5 11 1
11 7 12 1
12 10 13 2
13 6 9 2
14 7 10 1
15 1 14 1
16 14 15 1
17 15 16 1
18 15 17 1
|
|---|
