Entry |
|
Name |
Hydrocortisone probutate (USAN); Hydrocortisone butyrate propionate (JAN); Hydrocortisone buteprate; Pandel (TN) |
Product |
|
Formula |
C28H40O7
|
Exact mass |
488.2774
|
Mol weight |
488.613
|
Structure |
|
Simcomp |
|
Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Dermatological agent
DG03243 Atopic dermatitis agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
|
Remark |
Therapeutic category: | 2646 |
Product (DG00012): | D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US> |
|
Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Metabolism |
|
Interaction |
|
Structure map |
map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC03 Hydrocortisone
D01886 Hydrocortisone probutate (USAN) <JP/US>
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07E INTESTINAL ANTIINFLAMMATORY AGENTS
A07EA Corticosteroids acting locally
A07EA02 Hydrocortisone
D01886 Hydrocortisone probutate (USAN) <JP/US>
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA01 Hydrocortisone
D01886 Hydrocortisone probutate (USAN) <JP/US>
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, weak (group I)
D07AA02 Hydrocortisone
D01886 Hydrocortisone probutate (USAN) <JP/US>
D07AB Corticosteroids, moderately potent (group II)
D07AB11 Hydrocortisone buteprate
D01886 Hydrocortisone probutate (USAN) <JP/US>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XA Corticosteroids, weak, other combinations
D07XA01 Hydrocortisone
D01886 Hydrocortisone probutate (USAN) <JP/US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB09 Hydrocortisone
D01886 Hydrocortisone probutate (USAN) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA02 Hydrocortisone
D01886 Hydrocortisone probutate (USAN) <JP/US>
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB03 Hydrocortisone
D01886 Hydrocortisone probutate (USAN) <JP/US>
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA01 Hydrocortisone
D01886 Hydrocortisone probutate (USAN) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
Dermatitis and Pruitus Agents
Glucocorticoids, Medium Potency
Hydrocortisone
D01886 Hydrocortisone probutate (USAN)
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
Hydrocortisone
D01886 Hydrocortisone probutate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2646 Adrenocorticotropic hormones
D01886 Hydrocortisone probutate (USAN); Hydrocortisone butyrate propionate (JAN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
D01886 Hydrocortisone probutate
Dermatological agent
DG03243 Atopic dermatitis agent
D01886 Hydrocortisone probutate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
D01886 Hydrocortisone probutate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D01886 Hydrocortisone probutate
Dermatological agent
DG03243 Atopic dermatitis agent
D01886 Hydrocortisone probutate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D01886 Hydrocortisone probutate (USAN) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01886
Topical steroids potency [br08317.html]
Classification in Japan
D01886
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
|
Other DBs |
|
LinkDB |
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KCF data |
ATOM 35
1 C1y C 13.5800 -11.5500
2 C1y C 12.3900 -12.2500
3 C1z C 13.5800 -10.2200
4 C1x C 15.8900 -11.5500
5 C1y C 11.2000 -11.5500
6 C1x C 12.3900 -13.5800
7 C1z C 14.7700 -9.5200
8 C1x C 12.3900 -9.5200
9 C1a C 13.5800 -8.8200
10 C1x C 15.8900 -10.2200
11 C1z C 10.0100 -12.2500
12 C1y C 11.2000 -10.2200
13 C1x C 11.2000 -14.2800
14 C5a C 14.7700 -8.1200
15 C2y C 10.0100 -13.5800
16 C1x C 8.8200 -11.5500
17 C1a C 10.0100 -10.8500
18 O1a O 10.0100 -9.5200
19 O5a O 13.5800 -7.4200
20 C2x C 8.8200 -14.2800
21 C1x C 7.6300 -12.2500
22 C5x C 7.6300 -13.5800
23 O5x O 6.4400 -14.2800
24 C1b C 15.9600 -7.4200
25 O7a O 17.1500 -8.1200
26 C7a C 18.3400 -7.4200
27 C1b C 19.5300 -8.1200
28 C1a C 20.7200 -7.4200
29 O6a O 18.3400 -6.0200
30 O7a O 15.9600 -8.8200
31 C7a C 17.1500 -9.5200
32 C1b C 18.4100 -8.8900
33 C1b C 19.6000 -9.5900
34 C1a C 20.8600 -8.9600
35 O6a O 17.1500 -10.9200
BOND 38
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 1
8 3 9 1 #Up
9 4 10 1
10 5 11 1
11 5 12 1
12 6 13 1
13 7 14 1 #Up
14 11 15 1
15 11 16 1
16 11 17 1 #Up
17 12 18 1 #Up
18 14 19 2
19 15 20 2
20 16 21 1
21 20 22 1
22 22 23 2
23 7 10 1
24 8 12 1
25 13 15 1
26 21 22 1
27 14 24 1
28 24 25 1
29 25 26 1
30 26 27 1
31 27 28 1
32 26 29 2
33 7 30 1 #Down
34 30 31 1
35 31 32 1
36 32 33 1
37 33 34 1
38 31 35 2
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