| Entry |
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| Name |
Dexamethasone valerate (JAN);
Dexamethasone 17-valerate;
DV-17;
Voalla ointment (TN) |
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| Formula |
C27H37FO6
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| Exact mass |
476.2574
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| Mol weight |
476.5775
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Dermatological agent
DG03243 Atopic dermatitis agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
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| Remark |
| Therapeutic category: | 2646 |
| Product (DG00011): | D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP> |
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576]
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC02 Dexamethasone
D01948 Dexamethasone valerate (JAN) <JP>
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA09 Dexamethasone
D01948 Dexamethasone valerate (JAN) <JP>
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB19 Dexamethasone
D01948 Dexamethasone valerate (JAN) <JP>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XB Corticosteroids, moderately potent, other combinations
D07XB05 Dexamethasone
D01948 Dexamethasone valerate (JAN) <JP>
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA03 Dexamethasone
D01948 Dexamethasone valerate (JAN) <JP>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB02 Dexamethasone
D01948 Dexamethasone valerate (JAN) <JP>
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD03 Dexamethasone
D01948 Dexamethasone valerate (JAN) <JP>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA01 Dexamethasone
D01948 Dexamethasone valerate (JAN) <JP>
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB01 Dexamethasone
D01948 Dexamethasone valerate (JAN) <JP>
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA06 Dexamethasone
D01948 Dexamethasone valerate (JAN) <JP>
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03B CORTICOSTEROIDS
S03BA Corticosteroids
S03BA01 Dexamethasone
D01948 Dexamethasone valerate (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2646 Adrenocorticotropic hormones
D01948 Dexamethasone valerate (JAN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
D01948 Dexamethasone valerate
Dermatological agent
DG03243 Atopic dermatitis agent
D01948 Dexamethasone valerate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
D01948 Dexamethasone valerate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
D01948 Dexamethasone valerate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D01948 Dexamethasone valerate
Dermatological agent
DG03243 Atopic dermatitis agent
D01948 Dexamethasone valerate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D01948 Dexamethasone valerate (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01948
Topical steroids potency [br08317.html]
Classification in Japan
D01948
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 34
1 C2x C 14.8604 -19.2419
2 C5x C 14.8604 -20.6015
3 C2x C 16.0379 -21.2814
4 C2y C 17.2153 -20.6015
5 C1z C 17.2153 -19.2419
6 C2x C 16.0379 -18.5620
7 C1x C 18.3928 -21.2814
8 C1x C 19.5703 -20.6015
9 C1y C 19.5703 -19.2419
10 C1z C 18.3928 -18.5620
11 C1y C 20.7478 -18.5620
12 C1z C 20.7478 -17.2024
13 C1x C 19.5703 -16.5225
14 C1y C 18.3928 -17.2024
15 C1x C 23.1028 -18.5620
16 C1y C 23.1028 -17.2024
17 C1z C 21.9253 -16.5225
18 C5a C 21.9306 -14.8129
19 C1b C 20.7531 -14.1331
20 O1a O 19.5756 -14.7195
21 O5a O 23.1236 -14.1271
22 O7a O 23.1363 -15.8333
23 C7a C 24.9581 -15.8333
24 O6a O 25.6590 -17.0472
25 C1b C 25.6590 -14.6193
26 C1b C 27.0609 -14.6193
27 C1b C 27.7612 -13.4063
28 C1a C 29.1566 -13.4063
29 C1a C 24.5273 -17.1841
30 X F 18.4084 -19.9867
31 O5x O 13.6486 -21.3012
32 C1a C 17.1938 -17.8381
33 O1a O 17.1832 -16.5039
34 C1a C 20.7438 -15.8762
BOND 37
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 17 18 1 #Up
22 18 19 1
23 19 20 1
24 18 21 2
25 17 22 1 #Down
26 22 23 1
27 23 24 2
28 23 25 1
29 25 26 1
30 26 27 1
31 27 28 1
32 16 29 1 #Down
33 10 30 1 #Down
34 2 31 2
35 5 32 1 #Up
36 14 33 1 #Up
37 12 34 1 #Up
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