| Entry |
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| Name |
Fosphenytoin sodium (USP);
Cerebyx (TN);
Sesquient (TN) |
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| Product |
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| Generic |
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| Formula |
C16H13N2O6P. 2Na
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| Exact mass |
406.0307
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| Mol weight |
406.2375
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG02031 Hydantoin antiepileptic
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01639 CYP2C19 substrate
Metabolizing enzyme inducer
DG02891 CYP2B6 inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
Transporter inducer
DG01893 ABCB1 inducer
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| Remark |
| Product (DG00847): | D02096<US> D07595<JP> |
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| Efficacy |
Anticonvulsant |
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| Comment |
Hydantoin derivative
Active form of prodrug: Phenytoin [DR: D00512]
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]; CYP2C19 [HSA: 1557]
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576], CYP2B6 [HSA: 1555]
Transporter induction: ABCB1 [HSA: 5243]
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AB Hydantoin derivatives
N03AB05 Fosphenytoin
D02096 Fosphenytoin sodium (USP) <US>
USP drug classification [BR:br08302]
Anticonvulsants
Sodium Channel Agents
Fosphenytoin
D02096 Fosphenytoin sodium (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG02031 Hydantoin antiepileptic
DG00847 Fosphenytoin
D02096 Fosphenytoin sodium
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00847 Fosphenytoin
D02096 Fosphenytoin sodium
DG01639 CYP2C19 substrate
DG00847 Fosphenytoin
D02096 Fosphenytoin sodium
Metabolizing enzyme inducer
DG02891 CYP2B6 inducer
DG00847 Fosphenytoin
D02096 Fosphenytoin sodium
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00847 Fosphenytoin
D02096 Fosphenytoin sodium
Transporter inducer
DG01893 ABCB1 inducer
DG00847 Fosphenytoin
D02096 Fosphenytoin sodium
Drug classes [BR:br08332]
Neuropsychiatric agent
DG03199 Antiepileptic agent
D02096 Fosphenytoin sodium
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D02096 Fosphenytoin sodium (USP) <US>
SCN2A
D02096 Fosphenytoin sodium (USP) <US>
SCN3A
D02096 Fosphenytoin sodium (USP) <US>
SCN4A
D02096 Fosphenytoin sodium (USP) <US>
SCN5A
D02096 Fosphenytoin sodium (USP) <US>
SCN8A
D02096 Fosphenytoin sodium (USP) <US>
SCN9A
D02096 Fosphenytoin sodium (USP) <US>
SCN10A
D02096 Fosphenytoin sodium (USP) <US>
SCN11A
D02096 Fosphenytoin sodium (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02096
Drug transporters
D02096
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D02096
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG02031 Hydantoin antiepileptic
DG00847 Fosphenytoin
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00847 Fosphenytoin
DG01639 CYP2C19 substrate
DG00847 Fosphenytoin
Metabolizing enzyme inducer
DG02891 CYP2B6 inducer
DG00847 Fosphenytoin
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00847 Fosphenytoin
Transporter inducer
DG01893 ABCB1 inducer
DG00847 Fosphenytoin
Prodrugs [br08324.html]
DG00847
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 27
1 Z Na 13.2864 -17.8245 #+
2 Z Na 9.8618 -21.7310 #+
3 C1z C 17.0800 -21.2800
4 N1x N 17.5700 -20.0200
5 C5x C 16.4500 -19.2500
6 N1y N 15.2600 -20.0200
7 C5x C 15.7500 -21.2800
8 O5x O 16.4500 -17.7800
9 O5x O 14.9800 -22.4700
10 C8y C 18.4800 -21.2800
11 C8x C 19.1800 -22.5400
12 C8x C 20.6500 -22.5400
13 C8x C 21.3500 -21.3500
14 C8x C 20.5800 -20.0900
15 C8x C 19.1800 -20.0900
16 C8y C 17.0800 -22.7500
17 C8x C 15.8900 -23.3800
18 C8x C 15.8900 -24.7800
19 C8x C 17.1500 -25.5500
20 C8x C 18.3400 -24.8500
21 C8x C 18.3400 -23.4500
22 C1b C 14.1400 -19.3200
23 O2b O 12.9500 -20.0200
24 P1b P 11.7600 -19.3200
25 O1c O 10.4300 -20.1600 #-
26 O1c O 11.7600 -17.9200 #-
27 O1c O 10.5700 -18.6200
BOND 27
1 3 4 1
2 4 5 1
3 5 6 1
4 6 7 1
5 3 7 1
6 5 8 2
7 7 9 2
8 3 10 1
9 10 11 2
10 11 12 1
11 12 13 2
12 13 14 1
13 14 15 2
14 10 15 1
15 3 16 1
16 16 17 2
17 17 18 1
18 18 19 2
19 19 20 1
20 20 21 2
21 16 21 1
22 22 6 1
23 22 23 1
24 23 24 1
25 24 25 1
26 24 26 1
27 24 27 2
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