KEGG   DRUG: Proparacaine hydrochloride
Entry
D02098                      Drug                                   
Name
Proparacaine hydrochloride (USP);
Alcaine (TN);
Ophthetic (TN)
Product
  Generic
ALCAINE (Alcon Laboratories), PROPARACAINE HYDROCHLORIDE (A-S Medication Solutions), PROPARACAINE HYDROCHLORIDE (Bausch & Lomb Incorporated), PROPARACAINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROPARACAINE HYDROCHLORIDE (REMEDYREPACK), PROPARACAINE HYDROCHLORIDE (Sandoz)
Formula
C16H26N2O3. HCl
Exact mass
330.171
Mol weight
330.8502
Structure
Simcomp
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
Remark
ATC code: S01HA04
Chemical structure group: DG01145
Product (DG01145): D02098<US>
Efficacy
Anesthetic (topical, ophthalmic)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
Interaction
Structure map
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA04 Proxymetacaine
      D02098  Proparacaine hydrochloride (USP) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01145  Proxymetacaine
     D02098  Proparacaine hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D02098  Proparacaine hydrochloride (USP) <US>
    SCN2A
     D02098  Proparacaine hydrochloride (USP) <US>
    SCN3A
     D02098  Proparacaine hydrochloride (USP) <US>
    SCN4A
     D02098  Proparacaine hydrochloride (USP) <US>
    SCN5A
     D02098  Proparacaine hydrochloride (USP) <US>
    SCN8A
     D02098  Proparacaine hydrochloride (USP) <US>
    SCN9A
     D02098  Proparacaine hydrochloride (USP) <US>
    SCN10A
     D02098  Proparacaine hydrochloride (USP) <US>
    SCN11A
     D02098  Proparacaine hydrochloride (USP) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01145  Proxymetacaine
Other DBs
CAS: 5875-06-9
PubChem: 7849159
LigandBox: D02098
NIKKAJI: J220.046E
LinkDB
KCF data

ATOM        22
            1   C8y C    24.7791  -18.1883
            2   C8x C    23.5468  -18.8775
            3   C8x C    24.7850  -16.7810
            4   C7a C    25.9880  -18.8892
            5   C8y C    22.3495  -18.1707
            6   C8x C    23.5702  -16.0685
            7   O7a O    27.1969  -18.2000
            8   O6a O    25.9763  -20.2967
            9   C8y C    22.3555  -16.7751
            10  N1a N    21.1289  -18.8599
            11  C1b C    28.4118  -18.9008
            12  O2a O    21.1465  -16.0626
            13  C1b C    29.6265  -18.2058
            14  C1b C    19.9320  -16.7576
            15  N1c N    30.8412  -18.9066
            16  C1b C    18.7230  -16.0626
            17  C1b C    32.0502  -18.2117
            18  C1b C    30.8354  -20.3084
            19  C1a C    17.5199  -16.7576
            20  C1a C    33.2591  -18.9125
            21  C1a C    32.0385  -21.0209
            22  X   Cl   32.0601  -15.9134
BOND        21
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     4   8 2
            8     5   9 1
            9     5  10 1
            10    7  11 1
            11    9  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17   15  18 1
            18   16  19 1
            19   17  20 1
            20   18  21 1
            21    6   9 2

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