| Entry |
|
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| Name |
Nalmefene hydrochloride;
Revex (TN) |
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| Product |
|
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| Generic |
|
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| Formula |
C21H25NO3. HCl
|
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| Exact mass |
375.1601
|
|---|
| Mol weight |
375.889
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Analgesic
DG01586 Opioid receptor antagonist
DG01587 Opioid receptor agonist/antagonist
|
|---|
| Remark |
| Product (DG00998): | D02104<US> D10812<JP> |
|
|---|
| Efficacy |
Antialcohol dependence, Narcotic antagonist, Opioid receptor partial agonist/antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07B DRUGS USED IN ADDICTIVE DISORDERS
N07BB Drugs used in alcohol dependence
N07BB05 Nalmefene
D02104 Nalmefene hydrochloride <US>
USP drug classification [BR:br08302]
Anti-Addiction/Substance Abuse Treatment Agents
Opioid Reversal Agents
Nalmefene
D02104 Nalmefene hydrochloride
Drug groups [BR:br08330]
Analgesic
DG01586 Opioid receptor antagonist
DG00998 Nalmefene
D02104 Nalmefene hydrochloride
DG01587 Opioid receptor agonist/antagonist
DG00998 Nalmefene
D02104 Nalmefene hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D02104 Nalmefene hydrochloride <US>
OPRK1
D02104 Nalmefene hydrochloride <US>
OPRD1
D02104 Nalmefene hydrochloride <US>
Drug groups [BR:br08330]
Analgesic
DG01586 Opioid receptor antagonist
DG00998 Nalmefene
DG01587 Opioid receptor agonist/antagonist
DG00998 Nalmefene
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 26
1 X Cl 37.1700 -16.1000
2 C1z C 29.4000 -17.5000
3 C8y C 29.4000 -16.1700
4 C1z C 30.5900 -18.2000
5 C1y C 28.2800 -18.1300
6 C1x C 30.5900 -16.8700
7 C8y C 28.2800 -15.5400
8 C8y C 30.5900 -15.5400
9 C1y C 31.7100 -17.5000
10 C1x C 30.5900 -19.4600
11 O2x O 27.0200 -16.8000
12 C2y C 28.2800 -19.4600
13 C1x C 32.8300 -16.8700
14 C8y C 28.2800 -14.2100
15 C1x C 31.7100 -16.2400
16 C8x C 30.5900 -14.2100
17 N1y N 32.8300 -18.2000
18 C1x C 29.4000 -20.1600
19 C2a C 27.2300 -20.1600
20 C8x C 29.4700 -13.5800
21 O1a O 27.2300 -13.5800
22 O1a O 31.8500 -19.1100
23 C1b C 34.2300 -18.2000
24 C1y C 34.9300 -19.3900
25 C1x C 34.9300 -20.7900
26 C1x C 36.1200 -20.0900
BOND 30
1 2 3 1
2 2 4 1
3 2 5 1
4 2 6 1 #Up
5 3 7 2
6 3 8 1
7 4 9 1
8 4 10 1
9 5 11 1 #Down
10 5 12 1
11 6 13 1
12 7 14 1
13 8 15 1
14 8 16 2
15 9 17 1 #Up
16 10 18 1
17 12 19 2
18 14 20 2
19 14 21 1
20 7 11 1
21 9 15 1
22 12 18 1
23 13 17 1
24 16 20 1
25 4 22 1 #Up
26 17 23 1
27 23 24 1
28 24 25 1
29 24 26 1
30 25 26 1
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