KEGG   DRUG: Epinephrine bitartrate
Entry
D02149                      Drug                                   
Name
Epinephrine bitartrate (JAN/USP);
Asmatane mist (TN);
Medihaler-epi (TN)
Formula
C9H13NO3. C4H6O6
Exact mass
333.106
Mol weight
333.2913
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
Metabolizing enzyme substrate
 DG01592  COMT substrate
 DG02917  MAO substrate
Remark
ATC code: A01AD01 B02BC09 C01CA24 R01AA14 R03AA01 S01EA01
Chemical structure group: DG00013
Product (DG00013): D00095<JP/US>
Product (mixture): D04813<JP/US> D04818<US> D11290<US> D11569<US>
Efficacy
Vasoconstrictor, Adrenergic receptor agonist
Comment
Catecholamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Metabolism
Enzyme: COMT [HSA:1312], MAO [HSA:4128 4129]
Interaction
Structure map
map07214  beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AD Other agents for local oral treatment
     A01AD01 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BC Local hemostatics
     B02BC09 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA24 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA14 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AA Alpha- and beta-adrenoreceptor agonists
     R03AA01 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA01 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01703  Cardiotonic
   DG01699  Catecholamine cardiotonic
    DG00013  Epinephrine
     D02149  Epinephrine bitartrate
  DG01456  Adrenergic receptor agonist
   DG00013  Epinephrine
    D02149  Epinephrine bitartrate
  DG01951  Catecholamine adrenergic receptor agonist
   DG00013  Epinephrine
    D02149  Epinephrine bitartrate
 Metabolizing enzyme substrate
  DG01592  COMT substrate
   DG00013  Epinephrine
    D02149  Epinephrine bitartrate
  DG02917  MAO substrate
   DG00013  Epinephrine
    D02149  Epinephrine bitartrate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D02149  Epinephrine bitartrate (JAN/USP)
    ADRA2
     D02149  Epinephrine bitartrate (JAN/USP)
    ADRB
     D02149  Epinephrine bitartrate (JAN/USP)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02149
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01703  Cardiotonic
   DG01699  Catecholamine cardiotonic
    DG00013  Epinephrine
  DG01456  Adrenergic receptor agonist
   DG00013  Epinephrine
  DG01951  Catecholamine adrenergic receptor agonist
   DG00013  Epinephrine
 Metabolizing enzyme substrate
  DG01592  COMT substrate
   DG00013  Epinephrine
  DG02917  MAO substrate
   DG00013  Epinephrine
Other DBs
CAS: 51-42-3
PubChem: 7849210
LigandBox: D02149
NIKKAJI: J231.238G
LinkDB
KCF data

ATOM        23
            1   C8y C    16.7785  -17.0333
            2   C8x C    16.7785  -18.4291
            3   C8x C    15.5689  -16.3355
            4   C1c C    17.9882  -16.3355
            5   C8x C    15.5689  -19.1735
            6   C8y C    14.3592  -17.0333
            7   C1b C    19.1978  -17.0333
            8   O1a O    17.9882  -14.9397
            9   C8y C    14.3592  -18.4291
            10  N1b N    20.4074  -16.3355
            11  O1a O    13.1496  -19.1269
            12  O1a O    13.1496  -16.3355
            13  C1a C    21.6171  -17.0333
            14  O6a O    25.0833  -17.0100
            15  C6a C    26.2958  -16.3100
            16  C1c C    27.5082  -17.0100
            17  C1c C    28.7207  -16.3100
            18  C6a C    29.9332  -17.0100
            19  O6a O    31.1456  -16.3100
            20  O6a O    29.9332  -18.4100
            21  O6a O    26.2958  -14.9100
            22  O1a O    28.7207  -14.9100
            23  O1a O    27.5082  -18.4100
BOND        22
            1     1   3 1
            2     1   4 1
            3     2   5 1
            4     3   6 2
            5     4   7 1
            6     4   8 1 #Up
            7     5   9 2
            8     7  10 1
            9     9  11 1
            10    6   9 1
            11    6  12 1
            12    1   2 2
            13   10  13 1
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   18  20 2
            20   15  21 2
            21   17  22 1 #Up
            22   16  23 1 #Up

» Japanese version   » Back

DBGET integrated database retrieval system