| Entry |
|
|---|
| Name |
l-Isoprenaline hydrochloride (JP18);
Proternol-L (TN) |
|---|
| Formula |
C11H17NO3. HCl
|
|---|
| Exact mass |
247.0975
|
|---|
| Mol weight |
247.7185
|
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| Structure |
|
|---|
| Simcomp |
|
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| Class |
Cardiovascular agent
DG01703 Cardiotonic
DG01699 Catecholamine cardiotonic
DG01456 Adrenergic receptor agonist
DG01455 beta-Adrenergic receptor agonist
DG01951 Catecholamine adrenergic receptor agonist
Metabolizing enzyme substrate
DG01592 COMT substrate
|
|---|
| Remark |
| Therapeutic category: | 2119 |
| Product (DG00211): | D01390<JP/US> D02150<JP> |
|
|---|
| Efficacy |
Bronchodilator, Cardiotonic, beta-Adrenergic receptor agonist |
|---|
| Comment |
Catecholamine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07214 | beta-Adrenergic receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
C01CA Adrenergic and dopaminergic agents
C01CA02 Isoprenaline
D02150 l-Isoprenaline hydrochloride (JP18) <JP>
R RESPIRATORY SYSTEM
R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03A ADRENERGICS, INHALANTS
R03AB Non-selective beta-adrenoreceptor agonists
R03AB02 Isoprenaline
D02150 l-Isoprenaline hydrochloride (JP18) <JP>
R03C ADRENERGICS FOR SYSTEMIC USE
R03CB Non-selective beta-adrenoreceptor agonists
R03CB01 Isoprenaline
D02150 l-Isoprenaline hydrochloride (JP18) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
211 Cardiotonics
2119 Others
D02150 l-Isoprenaline hydrochloride (JP18)
Drug groups [BR:br08330]
Cardiovascular agent
DG01703 Cardiotonic
DG01699 Catecholamine cardiotonic
DG00211 Isoprenaline
D02150 l-Isoprenaline hydrochloride
DG01456 Adrenergic receptor agonist
DG01455 beta-Adrenergic receptor agonist
DG00211 Isoprenaline
D02150 l-Isoprenaline hydrochloride
DG01951 Catecholamine adrenergic receptor agonist
DG00211 Isoprenaline
D02150 l-Isoprenaline hydrochloride
Metabolizing enzyme substrate
DG01592 COMT substrate
DG00211 Isoprenaline
D02150 l-Isoprenaline hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB
D02150 l-Isoprenaline hydrochloride (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02150 l-Isoprenaline hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02150
Drug groups [BR:br08330]
Cardiovascular agent
DG01703 Cardiotonic
DG01699 Catecholamine cardiotonic
DG00211 Isoprenaline
DG01456 Adrenergic receptor agonist
DG01455 beta-Adrenergic receptor agonist
DG00211 Isoprenaline
DG01951 Catecholamine adrenergic receptor agonist
DG00211 Isoprenaline
Metabolizing enzyme substrate
DG01592 COMT substrate
DG00211 Isoprenaline
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 16
1 X Cl 31.6400 -16.8700
2 C8y C 21.8400 -16.4500
3 C8x C 20.6500 -15.6800
4 C8x C 21.8400 -17.8500
5 C8y C 19.3900 -16.3800
6 C8x C 20.5800 -18.4800
7 C8y C 19.3900 -17.7100
8 O1a O 18.2000 -15.6100
9 O1a O 18.2000 -18.4100
10 C1c C 23.1000 -15.7500
11 C1b C 24.2900 -16.4500
12 N1b N 25.4800 -15.7500
13 C1c C 26.7400 -16.4500
14 C1a C 27.9300 -15.7500
15 O1a O 23.1000 -14.3500
16 C1a C 26.7400 -17.8500
BOND 15
1 2 3 1
2 2 4 2
3 3 5 2
4 4 6 1
5 5 7 1
6 5 8 1
7 7 9 1
8 6 7 2
9 2 10 1
10 10 11 1
11 11 12 1
12 12 13 1
13 13 14 1
14 10 15 1 #Up
15 13 16 1
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