| Entry |
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| Name |
Dexamethasone acetate (JAN/USP);
Decadronal (TN) |
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| Formula |
C24H31FO6. H2O
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| Exact mass |
452.221
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| Mol weight |
452.513
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
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| Remark |
| Product (DG00011): | D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP> |
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576]
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC02 Dexamethasone
D02174 Dexamethasone acetate (JAN/USP)
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA09 Dexamethasone
D02174 Dexamethasone acetate (JAN/USP)
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB19 Dexamethasone
D02174 Dexamethasone acetate (JAN/USP)
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XB Corticosteroids, moderately potent, other combinations
D07XB05 Dexamethasone
D02174 Dexamethasone acetate (JAN/USP)
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA03 Dexamethasone
D02174 Dexamethasone acetate (JAN/USP)
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB02 Dexamethasone
D02174 Dexamethasone acetate (JAN/USP)
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD03 Dexamethasone
D02174 Dexamethasone acetate (JAN/USP)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA01 Dexamethasone
D02174 Dexamethasone acetate (JAN/USP)
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB01 Dexamethasone
D02174 Dexamethasone acetate (JAN/USP)
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA06 Dexamethasone
D02174 Dexamethasone acetate (JAN/USP)
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03B CORTICOSTEROIDS
S03BA Corticosteroids
S03BA01 Dexamethasone
D02174 Dexamethasone acetate (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
D02174 Dexamethasone acetate (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Dexamethasone acetate
D02174 Dexamethasone acetate (JAN/USP)
Second-class OTC drugs
Inorganic and organic chemicals
Dexamethasone acetate
D02174 Dexamethasone acetate (JAN/USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
D02174 Dexamethasone acetate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
D02174 Dexamethasone acetate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
D02174 Dexamethasone acetate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D02174 Dexamethasone acetate (JAN/USP)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02174
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 32
1 C2x C 17.7128 -16.5491
2 C5x C 17.7128 -17.9064
3 C2x C 18.8882 -18.5850
4 C2y C 20.0636 -17.9064
5 C1z C 20.0636 -16.5491
6 C2x C 18.8882 -15.8705
7 C1x C 21.2391 -18.5850
8 C1x C 22.4144 -17.9064
9 C1y C 22.4144 -16.5491
10 C1z C 21.2391 -15.8705
11 C1y C 23.5899 -15.8705
12 C1z C 23.5899 -14.5132
13 C1x C 22.4144 -13.8346
14 C1y C 21.2391 -14.5132
15 C1x C 25.9407 -15.8705
16 C1y C 25.9407 -14.5132
17 C1z C 24.7653 -13.8346
18 C1a C 20.0636 -15.1918
19 O1a O 20.0656 -13.8358
20 C1a C 23.5899 -13.1560
21 C1a C 27.1036 -13.8417
22 C5a C 24.7653 -12.1381
23 X F 21.2391 -17.2277
24 O1a O 25.9407 -12.9465
25 O5x O 16.5375 -18.5850
26 O5a O 25.9447 -11.4572
27 C1b C 23.5938 -11.4617
28 O7a O 22.4368 -12.1299
29 C7a C 21.2411 -11.4393
30 C1a C 20.0186 -12.1452
31 O6a O 21.2419 -10.0104
32 O0 O 28.9100 -16.8700
BOND 34
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 5 18 1 #Up
22 14 19 1 #Up
23 12 20 1 #Up
24 16 21 1 #Down
25 17 22 1 #Up
26 10 23 1 #Down
27 17 24 1 #Down
28 2 25 2
29 22 26 2
30 22 27 1
31 27 28 1
32 28 29 1
33 29 30 1
34 29 31 2
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