| Entry |
|
|---|
| Name |
Pilocarpine hydrochloride (JP18/USP);
Isopto carpine (TN);
Pilopine HS (TN);
Salagen (TN);
Sanpilo (TN) |
|---|
| Product |
|
|---|
| Generic |
PILOCARPINE HYDRCHLORIDE (Bryant Ranch Prepack), PILOCARPINE HYDRCHLORIDE (Bryant Ranch Prepack), PILOCARPINE HYDRCHLORIDE (Bryant Ranch Prepack), PILOCARPINE HYDRCHLORIDE (Padagis US LLC), PILOCARPINE HYDROCHLORIDE (AMICI PHARMACEUTICALS LLC), PILOCARPINE HYDROCHLORIDE (Actavis Pharma), PILOCARPINE HYDROCHLORIDE (American Health Packaging), PILOCARPINE HYDROCHLORIDE (Amneal Pharmaceuticals NY LLC), PILOCARPINE HYDROCHLORIDE (Amneal Pharmaceuticals NY LLC), PILOCARPINE HYDROCHLORIDE (Aurobindo Pharma Limited), PILOCARPINE HYDROCHLORIDE (AvPAK), PILOCARPINE HYDROCHLORIDE (Bryant Ranch Prepack), PILOCARPINE HYDROCHLORIDE (Bryant Ranch Prepack), PILOCARPINE HYDROCHLORIDE (Bryant Ranch Prepack), PILOCARPINE HYDROCHLORIDE (Lannett Company), PILOCARPINE HYDROCHLORIDE (NorthStar Rx LLC), PILOCARPINE HYDROCHLORIDE (Sandoz), PILOCARPINE HYDROCHLORIDE (Somerset Therapeutics) |
|---|
| Formula |
C11H16N2O2. HCl
|
|---|
| Exact mass |
244.0979
|
|---|
| Mol weight |
244.7179
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
DG01719 Parasympathomimetic agent
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
|
|---|
| Remark |
| Product (DG00992): | D02200<JP/US> |
|
|---|
| Efficacy |
Antiglaucoma, Miotic, Salivation accelaletor, Muscarinic acetylcholine receptor agonist |
|---|
| Disease |
Open-angle glaucoma [DS: H00612] Sjogren's Syndrome [DS: H01502] |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2A6 [HSA: 1548]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07220 | Cholinergic and anticholinergic drugs |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07A PARASYMPATHOMIMETICS
N07AX Other parasympathomimetics
N07AX01 Pilocarpine
D02200 Pilocarpine hydrochloride (JP18/USP) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EB Parasympathomimetics
S01EB01 Pilocarpine
D02200 Pilocarpine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Dental and Oral Agents
Pilocarpine
D02200 Pilocarpine hydrochloride (JP18/USP)
Ophthalmic Agents
Intraocular Pressure Lowering Agents
Cholinergic Agonists, Ophthalmic
Pilocarpine
D02200 Pilocarpine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1312 Miotic agents
D02200 Pilocarpine hydrochloride (JP18/USP)
2 Agents affecting individual organs
23 Digestive organ agents
239 Miscellaneous
2399 Others
D02200 Pilocarpine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
DG00992 Pilocarpine
D02200 Pilocarpine hydrochloride
DG01719 Parasympathomimetic agent
DG00992 Pilocarpine
D02200 Pilocarpine hydrochloride
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00992 Pilocarpine
D02200 Pilocarpine hydrochloride
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
DG00992 Pilocarpine
D02200 Pilocarpine hydrochloride
Drug classes [BR:br08332]
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
D02200 Pilocarpine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM2
D02200 Pilocarpine hydrochloride (JP18/USP) <JP/US>
CHRM3
D02200 Pilocarpine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02200 Pilocarpine hydrochloride
D02200 Pilocarpine hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02200
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
DG00992 Pilocarpine
DG01719 Parasympathomimetic agent
DG00992 Pilocarpine
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00992 Pilocarpine
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
DG00992 Pilocarpine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 16
1 C1y C 22.9454 -19.7221
2 C1y C 21.4986 -19.7221
3 C1b C 24.1589 -20.3289
4 C1x C 23.3654 -18.3687
5 C7x C 21.0786 -18.3687
6 C1b C 20.7052 -20.8422
7 C8y C 25.2323 -19.7221
8 O7x O 22.2454 -17.5286
9 O6a O 19.7251 -17.9019
10 C1a C 19.3051 -20.8422
11 N4y N 26.6324 -19.7221
12 C8x C 24.7656 -18.3687
13 C8x C 27.0525 -18.3687
14 C1a C 27.4725 -20.8422
15 N5x N 25.9323 -17.5286
16 X Cl 29.8072 -18.8353
BOND 16
1 1 2 1
2 1 3 1 #Down
3 1 4 1
4 2 5 1
5 2 6 1 #Down
6 3 7 1
7 4 8 1
8 5 9 2
9 6 10 1
10 7 11 1
11 7 12 2
12 11 13 1
13 11 14 1
14 12 15 1
15 5 8 1
16 13 15 2
|
|---|
