KEGG   DRUG: Sparteine sulfate
Entry
D02239                      Drug                                   
Name
Sparteine sulfate (JAN/USAN);
Sparteine sulfate pentahydrate
Formula
C15H26N2. H2SO4. 5H2O
Exact mass
422.2298
Mol weight
422.5352
Structure
Simcomp
Source
Sarothmus scoparius [TAX:3835]
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: C01BA04
Chemical structure group: DG00195
Efficacy
Antiarrhythmic, Oxytocic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA04 Sparteine
      D02239  Sparteine sulfate (JAN/USAN)
Animal drugs in Japan [BR:br08331]
 94  Agents for breeding
  942  Oxytocics
   9421  Sparteine and preparations
    D02239  Sparteine sulfate
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG00195  Sparteine
      D02239  Sparteine sulfate
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00195  Sparteine
    D02239  Sparteine sulfate
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D02239  Sparteine sulfate (JAN/USAN)
    SCN2A
     D02239  Sparteine sulfate (JAN/USAN)
    SCN3A
     D02239  Sparteine sulfate (JAN/USAN)
    SCN4A
     D02239  Sparteine sulfate (JAN/USAN)
    SCN5A
     D02239  Sparteine sulfate (JAN/USAN)
    SCN8A
     D02239  Sparteine sulfate (JAN/USAN)
    SCN9A
     D02239  Sparteine sulfate (JAN/USAN)
    SCN10A
     D02239  Sparteine sulfate (JAN/USAN)
    SCN11A
     D02239  Sparteine sulfate (JAN/USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02239
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG00195  Sparteine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00195  Sparteine
Other DBs
CAS: 6160-12-9
PubChem: 7849298
LigandBox: D02239
LinkDB
KCF data

ATOM        27
            1   C1x C    16.8979  -16.8608
            2   C1x C    16.8979  -18.2571
            3   C1x C    18.1101  -18.9554
            4   C1x C    18.1101  -16.1625
            5   C1y C    19.3153  -16.8608
            6   N1y N    19.3093  -18.2571
            7   C1x C    20.5157  -18.9605
            8   C1y C    21.7279  -18.2675
            9   C1x C    21.7338  -16.8711
            10  C1y C    20.5275  -16.1676
            11  C1x C    21.7289  -15.4573
            12  N1y N    22.9419  -16.1414
            13  C1y C    22.9278  -17.5589
            14  C1x C    24.1484  -18.2798
            15  C1x C    25.3831  -17.5834
            16  C1x C    25.4204  -16.1657
            17  C1x C    24.1766  -15.4447
            18  S4a S    28.9498  -16.9728
            19  O1d O    30.3513  -16.9728
            20  O1d O    27.5483  -16.9657
            21  O1d O    29.0129  -15.5713
            22  O1d O    29.0129  -18.3743
            23  O0  O    34.5659  -16.9545
            24  O0  O    34.5659  -16.9545
            25  O0  O    34.5659  -16.9545
            26  O0  O    34.5659  -16.9545
            27  O0  O    34.5659  -16.9545
BOND        24
            1     8   9 1 #Up
            2    10   9 1 #Up
            3    10   5 1
            4    10  11 1
            5     8  13 1
            6    11  12 1
            7     1   2 1
            8     2   3 1
            9     3   6 1
            10    5   4 1
            11    4   1 1
            12    5   6 1
            13    6   7 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  12 1
            20    7   8 1
            21   18  19 1
            22   18  20 1
            23   18  21 2
            24   18  22 2
BRACKET     1    32.6200  -18.0600   32.6200  -15.8900
            1    35.2800  -15.8900   35.2800  -18.0600
            1  5
 ORIGINAL  1   25
 REPEAT    1   26  27  28  29

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