| Entry |
|
|---|
| Name |
Itopride hydrochloride (JAN);
Ganaton (TN) |
|---|
| Formula |
C20H26N2O4. HCl
|
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| Exact mass |
394.1659
|
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| Mol weight |
394.8924
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG01594 Butyrylcholinesterase inhibitor
Gastrointestinal agent
DG01763 Propulsive
Unclassified
DG03306 FMO substrate
DG03191 FMO1 substrate
DG02950 FMO3 substrate
|
|---|
| Remark |
| Therapeutic category: | 2399 |
| Product (DG01395): | D02729<JP> |
|
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| Efficacy |
Prokinetic, Dopamine receptor antagonist |
|---|
| Comment |
Benzamide derivative
|
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| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: FMO1 [HSA: 2326], FMO3 [HSA: 2328]
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
A03F PROPULSIVES
A03FA Propulsives
A03FA07 Itopride
D02729 Itopride hydrochloride (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
239 Miscellaneous
2399 Others
D02729 Itopride hydrochloride (JAN)
Risk category of Japanese OTC drugs [BR:br08312]
Drugs requiring guidance
New approved switch OTC drugs
Itopride hydrochloride
D02729 Itopride hydrochloride (JAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG01395 Itopride
D02729 Itopride hydrochloride
DG01594 Butyrylcholinesterase inhibitor
DG01395 Itopride
D02729 Itopride hydrochloride
Gastrointestinal agent
DG01763 Propulsive
DG01395 Itopride
D02729 Itopride hydrochloride
Unclassified
DG03306 FMO substrate
DG03191 FMO1 substrate
DG01395 Itopride
D02729 Itopride hydrochloride
DG02950 FMO3 substrate
DG01395 Itopride
D02729 Itopride hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D02729 Itopride hydrochloride (JAN) <JP>
Enzymes
Hydrolases (EC3)
Carboxylic-ester hydrolases
ACHE
D02729 Itopride hydrochloride (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02729
Rx-to-OTC switch list in Japan [br08314.html]
D02729
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG01395 Itopride
DG01594 Butyrylcholinesterase inhibitor
DG01395 Itopride
Gastrointestinal agent
DG01763 Propulsive
DG01395 Itopride
Unclassified
DG03306 FMO substrate
DG03191 FMO1 substrate
DG01395 Itopride
DG02950 FMO3 substrate
DG01395 Itopride
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 27
1 C8y C 14.4200 -16.2400
2 C8x C 14.4200 -14.8400
3 C8x C 13.1600 -16.9400
4 C5a C 15.6800 -16.9400
5 C8x C 13.1600 -14.1400
6 C8y C 11.9700 -16.2400
7 N1b N 16.8700 -16.2400
8 O5a O 15.6800 -18.3400
9 C8y C 11.9700 -14.8400
10 O2a O 10.7800 -16.9400
11 C1b C 18.1300 -16.9400
12 O2a O 10.7800 -14.1400
13 C8y C 19.3200 -16.2400
14 C1a C 9.5200 -14.8400
15 C1a C 9.5200 -16.3100
16 C8x C 20.5100 -16.9400
17 C8x C 21.7000 -16.2400
18 C8y C 21.7000 -14.8400
19 C8x C 20.5100 -14.1400
20 C8x C 19.3200 -14.8400
21 O2a O 22.9600 -14.1400
22 C1b C 24.1500 -14.8400
23 C1b C 25.3400 -14.1400
24 N1c N 26.6000 -14.8400
25 C1a C 27.7900 -14.1400
26 C1a C 26.6000 -16.2400
27 X Cl 24.5700 -18.8300
BOND 27
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 3 6 1
6 4 7 1
7 4 8 2
8 5 9 1
9 6 10 1
10 7 11 1
11 9 12 1
12 11 13 1
13 6 9 2
14 12 14 1
15 10 15 1
16 13 16 2
17 16 17 1
18 17 18 2
19 18 19 1
20 19 20 2
21 13 20 1
22 18 21 1
23 21 22 1
24 22 23 1
25 23 24 1
26 24 25 1
27 24 26 1
|
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