| Entry |
|
|---|
| Name |
Vardenafil dihydrochoride (USAN);
Levitra (TN) |
|---|
| Formula |
C23H32N6O4S. 2HCl
|
|---|
| Exact mass |
560.1739
|
|---|
| Mol weight |
561.5249
|
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| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01509 Phosphodiesterase V inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00487): | D03260<JP/US> |
|
|---|
| Efficacy |
Vasodilator, Impotence therapy, Phosphodiesterase V inhibitor |
|---|
| Comment |
Treatment of erectile dysfunction
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G04 UROLOGICALS
G04B UROLOGICALS
G04BE Drugs used in erectile dysfunction
G04BE09 Vardenafil
D02731 Vardenafil dihydrochoride (USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01509 Phosphodiesterase V inhibitor
DG00487 Vardenafil
D02731 Vardenafil dihydrochoride
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00487 Vardenafil
D02731 Vardenafil dihydrochoride
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Phosphodiesterases
PDE5
D02731 Vardenafil dihydrochoride (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02731
Drug groups [BR:br08330]
Cardiovascular agent
DG01509 Phosphodiesterase V inhibitor
DG00487 Vardenafil
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00487 Vardenafil
|
|---|
| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 36
1 C8y C 31.5505 -18.2031
2 C8y C 32.7642 -17.4970
3 C8y C 31.5505 -19.6096
4 C8x C 30.3365 -17.5086
5 N4x N 33.9723 -18.1973
6 N5x N 32.7526 -16.0964
7 C8x C 30.3365 -20.3097
8 O2a O 32.7526 -20.3040
9 C8y C 29.1285 -18.2031
10 N4y N 35.1920 -17.5027
11 C8y C 33.9723 -15.3961
12 C8x C 29.1228 -19.6037
13 C1b C 33.9606 -19.6037
14 S4a S 27.9205 -17.5027
15 C8y C 35.1860 -16.1022
16 C8y C 36.5225 -17.9288
17 O5x O 33.9723 -13.9898
18 C1a C 35.1627 -20.3040
19 N1y N 26.7126 -18.1973
20 O3c O 28.9126 -16.5049
21 O3c O 26.9168 -16.5049
22 C8y C 36.5167 -15.6588
23 N5x N 37.3513 -16.7908
24 C1b C 36.9484 -19.2536
25 C1x C 26.7126 -19.5980
26 C1x C 25.4988 -17.4911
27 C1a C 36.9545 -14.3223
28 C1b C 38.3083 -19.5395
29 C1x C 25.4988 -20.2982
30 C1x C 24.2850 -18.1973
31 C1a C 38.7400 -20.8701
32 N1y N 24.2850 -19.5980
33 C1b C 23.0770 -20.3040
34 C1a C 21.8842 -19.6237
35 X Cl 41.4539 -17.6487
36 X Cl 41.4539 -17.6487
BOND 37
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 2
6 3 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 6 11 1
11 7 12 1
12 8 13 1
13 9 14 1
14 10 15 1
15 10 16 1
16 11 17 2
17 13 18 1
18 14 19 1
19 14 20 2
20 14 21 2
21 15 22 2
22 16 23 2
23 16 24 1
24 19 25 1
25 19 26 1
26 22 27 1
27 24 28 1
28 25 29 1
29 26 30 1
30 28 31 1
31 29 32 1
32 32 33 1
33 9 12 2
34 11 15 1
35 22 23 1
36 30 32 1
37 33 34 1
BRACKET 1 39.7600 -18.5500 39.7600 -16.6600
1 42.4900 -16.6600 42.4900 -18.5500
1 2
ORIGINAL 1 35
REPEAT 1 36
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