KEGG   DRUG: Teriparatide acetate
Entry
D03358                      Drug                                   
Name
Teriparatide acetate (JAN);
Human PHT (TN)
Formula
C181H291N55O51S2. (C2H4O2)5
Exact mass
4415.2366
Mol weight
4417.9749
Sequence
Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn
Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His
Asn Phe-OH
  Type
Peptide
Class
Hormonal agent
 DG01661  Parathyroid hormone and parathyroid hormone-related protein analog
Musculo-skeletal system agent
 DG03232  Osteoporosis agent
Remark
Therapeutic category: 2439 7223
ATC code: H05AA02
Chemical structure group: DG00512
Product (DG00512): D06078<JP/US> D03358<JP> D06546<US>
Efficacy
Diagnostic (parathyroid function), Osteoporosis agent, Parathyroid hormone receptor agonist
Target
PTH1R [HSA:5745] [KO:K04585]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04961  Endocrine and other factor-regulated calcium reabsorption
  Network
nt06318  CaSR-PTH signaling
Interaction
Structure map
map07047  Osteoporosis drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H05 CALCIUM HOMEOSTASIS
   H05A PARATHYROID HORMONES AND ANALOGUES
    H05AA Parathyroid hormones and analogues
     H05AA02 Teriparatide
      D03358  Teriparatide acetate (JAN) <JP>
USP drug classification [BR:br08302]
 Metabolic Bone Disease Agents
  Calcium Regulating Hormones
   Teriparatide
    D03358  Teriparatide acetate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   243  Thyroid and parathyroid hormone preparations
    2439  Others
     D03358  Teriparatide acetate (JAN)
 7  Agents not mainly for therapeutic purpose
  72  Intracorporeal diagnostic agents
   722  Various function testing reagents
    7223  Diagnostic reagents for endocrine function
     D03358  Teriparatide acetate (JAN)
Drug groups [BR:br08330]
 Hormonal agent
  DG01661  Parathyroid hormone and parathyroid hormone-related protein analog
   DG00512  Teriparatide
    D03358  Teriparatide acetate
 Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   DG00512  Teriparatide
    D03358  Teriparatide acetate
Drug classes [BR:br08332]
 Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   D03358  Teriparatide acetate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Secretin receptor family
   Parathyroid hormone
    PTH1R
     D03358  Teriparatide acetate (JAN) <JP>
Drug groups [BR:br08330]
 Hormonal agent
  DG01661  Parathyroid hormone and parathyroid hormone-related protein analog
   DG00512  Teriparatide
 Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   DG00512  Teriparatide
Other DBs
PubChem: 17397507
LinkDB

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KEGG   DRUG: Parathyroid hormone (human)
Entry
D05364                      Drug                                   
Name
Parathyroid hormone (human) (USAN);
Parathyroid hormone (INN);
ALX 1-11;
Parathormone;
PTH;
Natpara (TN)
Product
NATPARA (PARATHYROID HORMONE) (Takeda Pharmaceuticals America)
Formula
C408H674N126O126S2
Exact mass
9418.9648
Mol weight
9424.6158
Sequence
H-Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn
Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His
Asn Phe Val Ala Leu Gly Ala Pro Leu Ala Pro Arg Asp Ala Gly Ser
Gln Arg Pro Arg Lys Lys Glu Asp Asn Val Leu Val Glu Ser His Glu
Lys Ser Leu Gly Glu Ala Asp Lys Ala Asp Val Asn Val Leu Thr Lys
Ala Lys Ser Gln-OH
  Type
Peptide
Class
Hormonal agent
 DG01661  Parathyroid hormone and parathyroid hormone-related protein analog
Remark
Same as: C16051
ATC code: H05AA03
Product: D05364<US>
Efficacy
Diagnostic (pseudohypoparathyroidism, hypocalcemia), Osteoporosis agent, Parathyroid hormone receptor agonist
  Disease
Hypoparathyroidism [DS:H01862]
Comment
peptide hormone
Treatment of osteoporosis, as an antiosteoporotic, in the treatment of bone and mineral disease and disorders, bone metabolism regulator, blood calcium regulator
Target
PTH1R [HSA:5745] [KO:K04585]
PTH2R [HSA:5746] [KO:K04586]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04961  Endocrine and other factor-regulated calcium reabsorption
  Network
nt06318  CaSR-PTH signaling
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H05 CALCIUM HOMEOSTASIS
   H05A PARATHYROID HORMONES AND ANALOGUES
    H05AA Parathyroid hormones and analogues
     H05AA03 Parathyroid hormone
      D05364  Parathyroid hormone (human) (USAN) <US>
USP drug classification [BR:br08302]
 Metabolic Bone Disease Agents
  Calcium Regulating Hormones
   Parathyroid Hormone
    D05364  Parathyroid hormone (human) (USAN)
Drug groups [BR:br08330]
 Hormonal agent
  DG01661  Parathyroid hormone and parathyroid hormone-related protein analog
   D05364  Parathyroid hormone (human)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Secretin receptor family
   Parathyroid hormone
    PTH1R
     D05364  Parathyroid hormone (human) (USAN) <US>
    PTH2R
     D05364  Parathyroid hormone (human) (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D05364
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05364
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05364
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D05364
Other DBs
CAS: 68893-82-3
PubChem: 47207043
LinkDB

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KEGG   DRUG: Teriparatide
Entry
D06078                      Drug                                   
Name
Teriparatide (USP/INN);
Teriparatide (genetical recombination) (JAN);
Teriparatide (genetical recombination) [Teriparatide biosimilar 1] (JAN);
Forteo (TN)
Product
FORTEO (Eli Lilly and Company), TERIPARATIDE (Alvogen)
  Generic
TERIPARATIDE (Apotex Corp.), TERIPARATIDE (Prasco Laboratories)
Formula
C181H291N55O51S2
Exact mass
4115.1309
Mol weight
4117.7151
Sequence
Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn
Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His
Asn Phe-OH
  Type
Peptide
Class
Hormonal agent
 DG01661  Parathyroid hormone and parathyroid hormone-related protein analog
Musculo-skeletal system agent
 DG03232  Osteoporosis agent
Remark
Therapeutic category: 2439
ATC code: H05AA02
Chemical structure group: DG00512
Product (DG00512): D06078<JP/US> D03358<JP> D06546<US>
Efficacy
Antiresorptive, Osteoporosis agent, Parathyroid hormone receptor agonist
  Disease
Osteoporosis [DS:H01593]
Comment
Parathormone [CPD: C16051] analog
Target
PTH1R [HSA:5745] [KO:K04585]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04961  Endocrine and other factor-regulated calcium reabsorption
  Network
nt06318  CaSR-PTH signaling
Interaction
Structure map
map07047  Osteoporosis drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H05 CALCIUM HOMEOSTASIS
   H05A PARATHYROID HORMONES AND ANALOGUES
    H05AA Parathyroid hormones and analogues
     H05AA02 Teriparatide
      D06078  Teriparatide (USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Metabolic Bone Disease Agents
  Calcium Regulating Hormones
   Teriparatide
    D06078  Teriparatide (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   243  Thyroid and parathyroid hormone preparations
    2439  Others
     D06078  Teriparatide (USP/INN); Teriparatide (genetical recombination) (JAN); Teriparatide (genetical recombination) [Teriparatide biosimilar 1] (JAN)
Drug groups [BR:br08330]
 Hormonal agent
  DG01661  Parathyroid hormone and parathyroid hormone-related protein analog
   DG00512  Teriparatide
    D06078  Teriparatide
 Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   DG00512  Teriparatide
    D06078  Teriparatide
Drug classes [BR:br08332]
 Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   D06078  Teriparatide
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Secretin receptor family
   Parathyroid hormone
    PTH1R
     D06078  Teriparatide (USP/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06078
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06078
Drug groups [BR:br08330]
 Hormonal agent
  DG01661  Parathyroid hormone and parathyroid hormone-related protein analog
   DG00512  Teriparatide
 Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   DG00512  Teriparatide
Other DBs
CAS: 52232-67-4
PubChem: 47207736
NIKKAJI: J2.191.211E
LinkDB

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